Effect of COVID-19 on lipid profile parameters and its correlation with acute phase reactants: A single-center retrospective analysis

Almas, Talal; Malik, Jahanzeb; Alsubai, Abdulla K.; Ehtesham, Maryam; Laique, Talha; Ishaq, Uzma; Mehmood, Asad; Zaidi, Syed Muhammad Jawad; Hadeed, Sebastian; Huang, Helen; Oruk, Mert

doi:10.1016/j.amsu.2022.103856

Cited by 6 publications

(5 citation statements)

References 23 publications

(25 reference statements)

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“…Consequently, COVID-19-induced dyslipidemia has been implicated in the tendency to develop hyper-inflammatory responses among patients with the disease. Recent research evidence has shown that lipid parameters decreased with increasing severity of COVID-19 in association with inflammatory markers [24]. This finding is consistent with the conclusions of the current study where dyslipidemic cohorts had an increasing trend of various biomarkers consistent with inflammatory processes compared to the normolipidemic cohorts.…”

Section: B Relationship With Existing Literaturesupporting

confidence: 93%

“…This finding is consistent with the conclusions of the current study where dyslipidemic cohorts had an increasing trend of various biomarkers consistent with inflammatory processes compared to the normolipidemic cohorts. The inherent hyper-inflammatory responses in COVID-19 may well explain the lower lipid/lipoprotein parameters observed among the dyslipidemic patients with severe COVID-19 in the current study, which has previously been documented [24]. However, among the lipid/lipoprotein parameters evaluated and in line with previous studies, HDL had the most significant association with, and predictor of, severe COVID-19 disease [8]- [11], [25]- [27].…”

Section: B Relationship With Existing Literaturesupporting

confidence: 88%

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COVID-19-induced Dyslipidemia and Disease Severity: Perspectives from Southern Nigeria

et al. 2023

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Background: The relationship between dyslipidemia and the severity of coronavirus disease 2019 (COVID-19) has extensively been characterized in the Western population with a dearth of data among Nigerians. Hence, the current study evaluated the lipid/lipoprotein disorders inherent in COVID-19 and its relationship with disease severity among Nigerians. Methods: This was a retrospective study conducted among 600 patients with RT-PCR-confirmed COVID-19 at the Eleme COVID-19 treatment facility in Port Harcourt, Southern Nigeria. Data were obtained from medical records using validated acquisition templates and analyzed based on lipid/lipoprotein abnormalities and disease severity status. Results: Among those studied, 54.7% had dyslipidemia while others were normolipidemic. HDL-C dyslipidemia was the most common with a preponderance of hypoalphalipoproteinemia (84.4%). Dyslipidemia afflicted mostly middle-aged, males, urban dwellers, the overweight, and those with classic COVID-19-induced respiratory symptoms. Dyslipidemic cohorts had higher pro-calcitonin, C-reactive protein, D-dimer, total white cell count, and neutrophils, but lower albumin, lymphocyte, and platelet counts compared to the normolipidemic cohorts. Dyslipidemic cohorts with concurrent severe COVID-19 had lower levels of TChol, Tg, HDL-C, and LDL-C levels compared to patients with the less-severe disease. HDL-C was the only lipid/lipoprotein parameter that was associated with severe COVID-19 on crude (OR:8.65; CI:5.96-11.44; p<0.001) and adjusted (OR:8.11; CI:5.65-10.87; p<0.001) regression models compared to other lipid/lipoprotein indices. At 96.77% sensitivity and 89.20% specificity, HDL-C had robust predictive potentials (AUC:0.97; CI:0.84-1.00; p<0.001) over COVID-19 severity. Conclusion: Dyslipidemia is frequent among those presenting with COVID-19 in association with disease severity, especially among the HDL-C dyslipidemic cohorts. Hence, these findings should be factored in during COVID-19 treatment among Nigerians with the disease.

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Section: B Relationship With Existing Literaturesupporting

confidence: 93%

Section: B Relationship With Existing Literaturesupporting

confidence: 88%

COVID-19-induced Dyslipidemia and Disease Severity: Perspectives from Southern Nigeria

et al. 2023

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“…On the other hand, Jin et al reported that the patients infected during the first wave of COVID-19 with high levels of low-density lipoprotein cholesterol (LDL-c), triglyceride, and total cholesterol before infection and on admission had a poor progression of COVID-19 7 . Moreover, HDL-c, LDL-c, total cholesterol, and triglyceride were significantly lower in the patients with COVID-19 during the first wave of COVID-19, demonstrating that lipid profile predicts the severity of SARS-CoV-2 infection 52 . Al-Zadjali et al demonstrated that low HDL-c levels are associated with increase long-term COVID-19 severity in unvaccinated patients infected with SARS-CoV-2 after the first wave of COVID-19 53 .…”

Section: Discussionmentioning

confidence: 87%

Association between lipid profile and clinical outcomes in COVID-19 patients

Ochoa-Ramírez,

De la Herrán Arita,

Sanchez-Zazueta

et al. 2024

Sci Rep

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High-density lipoprotein cholesterol (HDL-c) removes cholesterol, an essential component in lipid rafts, and this cholesterol removal can regulate protein attachment to lipid rafts, modulating their functionality in the immune cell response. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can alter the lipid profile, there is little information on the role of HDL-c and other lipids in prognostic of the coronavirus disease 2019 (COVID-19) in Mexican population. This study aims to evaluate the predictive value of HDL-c and lipid profile on severity and survival of 102 patients infected with SARS-CoV-2 during the COVID-19 first wave. Our findings, derived from univariate and multivariate Cox proportional hazards regression models, highlighted age and hypertension as significant predictors of survival (HR = 1.04, p = 0.012; HR = 2.78, p = 0.027), while gender, diabetes, and obesity showed no significant impact. Triglycerides and HDL-c levels notably influenced mortality, with elevated triglycerides and lower HDL-c associated with higher mortality risk (p = 0.032). This study underscores the importance of lipid profiles alongside traditional risk factors in assessing COVID-19 risk and outcomes. It contributes to the understanding of COVID-19 patient management and emphasizes the need for further investigation into the role of dyslipidemia in influencing COVID-19 prognosis, potentially aiding in refined risk stratification and therapeutic strategies.

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“…Mild hypocalcemia was associated with severe forms of the disease, along with increased ferritin, creatinine, bilirubin, INR, and aspartate aminotransferase (AST) levels [60]. In a recent study, the increase in serum lipids was inversely associated with the level of acute-phase reactants [61]. Studies have also reported that the decrease in HDL cholesterol in infected patients was associated with the severity of COVID-19 infection [62].…”

Section: Discussionmentioning

confidence: 99%

Serum Calcium and Magnesium Levels in Patients with Type 2 Diabetes and COVID-19 Infection Requiring Hospitalization—Correlations with Various Parameters

Reștea,

Tigan,

Fritea

et al. 2024

Microbiology Research

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The purpose of this research was to analyze the impact of SARS-CoV-2 infection on ionic calcium, total calcium and serum magnesium upon hospital admission, taking into account the association of type 2 diabetes as a metabolic comorbidity. Our study included 57 patients: a group of 28 patients without diabetes, but with SARS-CoV-2 virus infection, and a second group of 29 patients with type 2 diabetes and SARS-CoV-2 virus infection. The serum level of calcium and magnesium of the patients included in the study did not differ statistically significantly in those with type 2 diabetes compared to those without type 2 diabetes who were infected with the SARS-CoV-2 virus at the time of hospitalization. Ionic calcium, total calcium, and serum magnesium did not statistically significantly influence the survival of the patients with COVID-19 infection included in this research, but the type of infection severity (mild or moderate) did influence the survival rate. Concerning the diabetic patients, a statistically significant correlation was found between serum total calcium and total serum proteins, and another one between ionic calcium and uric acid, urea, and total cholesterol. Serum total calcium and D-dimers were statistically significantly correlated with being transferred to the intensive care unit. On the other hand, magnesium significantly correlated with lipids (triglycerides, total lipids) and inflammatory (fibrinogen, ESR) biomarkers.

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Effect of COVID-19 on lipid profile parameters and its correlation with acute phase reactants: A single-center retrospective analysis

Cited by 6 publications

References 23 publications

COVID-19-induced Dyslipidemia and Disease Severity: Perspectives from Southern Nigeria

COVID-19-induced Dyslipidemia and Disease Severity: Perspectives from Southern Nigeria

Association between lipid profile and clinical outcomes in COVID-19 patients

Serum Calcium and Magnesium Levels in Patients with Type 2 Diabetes and COVID-19 Infection Requiring Hospitalization—Correlations with Various Parameters

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