Effect of counter-anions on the aggregation of Thioflavin-T

Desai, Akshat M.; Pandey, Shrishti P.; Singh, Prabhat Kumar

doi:10.1039/d1cp00193k

Cited by 5 publications

(4 citation statements)

References 72 publications

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“…Commonly studied OIPC salts are formed by a combination of pyrrolidinium, [18] imidazolium [19] or tetralkylamonium [20] cations and I − , PF 6 − , BF 4 − or SCN − as anions. It is interesting to note that, especially with respect to the study of OIPCs, it is well known for the anion choice to have large implications in terms of resulting molecular order, organization, physical and chemical properties of the systems being studied [21–26] . And in case of OIPCs, either one or even both of the ionic components can have rotational freedom in the PC phase (Figure 2).…”

Section: Introductionmentioning

confidence: 99%

“…It is interesting to note that, especially with respect to the study of OIPCs, it is well known for the anion choice to have large implications in terms of resulting molecular order, organization, physical and chemical properties of the systems being studied. [21][22][23][24][25][26] And in case of OIPCs, either one or even both of the ionic components can have rotational freedom in the PC phase (Figure 2). Rotational freedom, a globular shape and weak intermolecular interactions all contribute when wanting to achieve a significant amount of disorder before melting.…”

Section: Introductionmentioning

confidence: 99%

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Non‐Globular Organic Ionic Plastic Crystal Containing a Crown‐Ether Moiety – Tuning Its Behaviour Using Sodium Salts

et al. 2022

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Organic ionic plastic crystals (OIPCs) are a class of soft materials showing positional order while still allowing orientational freedom. Due to their motional freedom in the solid state, they possess plasticity, non-flammability and high ionic conductivity. OIPC behavior is typically exhibited by 'simple' globular molecules allowing molecular rotation, whereas the interactions that govern the formation of OIPC phases in complex nonglobular molecules are less understood. To better understand these interactions, a new family of non-globular OIPCs containing a 15-crown-5 ether moiety was synthetized and character-ized. The 15C5BA molecule prepared does not exhibit the sought-after behavior because of its non-globular nature and strong intermolecular H-bonds that restrict orientational motion. However, the OIPC behavior was successfully obtained through complexation of the crown-ether moiety with sodium salts containing chaotropic anions. Those anions weaken the interactions between the molecules, allowing rotational freedom and tuning of the thermal and morphological properties of the OIPC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Non‐Globular Organic Ionic Plastic Crystal Containing a Crown‐Ether Moiety – Tuning Its Behaviour Using Sodium Salts

et al. 2022

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“…ThT belongs to molecular rotor class of dye, and its excited‐state lifetime is reported to be highly sensitive towards its molecular state i. e., monomer or aggregate [57,58] . For example, monomers are characterized by short excited‐state lifetime, owing to efficient relaxation of excited‐state mediated by non‐radiative torsional relaxation of molecular fragments, whereas, aggregation can cause restriction to free rotation of the molecular fragments and can significantly affect the excited‐state relaxation process and lead to increase in excited‐state lifetime [58,59] . In the present case also, we have proposed that ThT undergoes aggregation in the presence of sulfated cyclodextrin molecules, and thus excited‐state lifetime is expected to bring significant insights into the effect of cavity size on efficiency of aggregation.…”

Section: Resultsmentioning

confidence: 55%

“…[57,58] For example, monomers are characterized by short excited-state lifetime, owing to efficient relaxation of excited-state mediated by nonradiative torsional relaxation of molecular fragments, whereas, aggregation can cause restriction to free rotation of the molecular fragments and can significantly affect the excitedstate relaxation process and lead to increase in excited-state lifetime. [58,59] In the present case also, we have proposed that ThT undergoes aggregation in the presence of sulfated cyclodextrin molecules, and thus excited-state lifetime is expected to bring significant insights into the effect of cavity size on efficiency of aggregation. In this regard, to test the effect of host cavity size of SCDs, on the excited-state lifetime modulation of ThT, we have performed excited-state lifetime measurements of ThT in the presence of various concentration of these host molecules (α-SCD, β-SCD and γ-SCD) and Figure 5A presents the obtained excited-state decay traces.…”

Section: Time-resolved Emission Measurementsmentioning

confidence: 65%

Guest Binding with Sulfated Cyclodextrins: Does the Size of Cavity Matter?

2022

Self Cite

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Sulfated cyclodextrins have recently emerged as potential candidates for producing host-induced guest aggregation with properties better than p-sulfonatocalixarenes that have previously shown numerous applications involving the phenomena of host-induced guest aggregation. In the class of sulfated cyclodextrins (SCD), sulfated β-cyclodextrin (β-SCD) remains the most extensively investigated host molecule. Although it is assumed that the host-induced guest aggregation is predominantly an outcome of interaction of the guest molecule with the charges on the exterior of SCD cavity, it has not been deciphered whether the variation in the cavity size will make a difference in the efficiency of host-induced guest-aggregation process. In this investigation, we present a systematic study of host-induced guest aggregation of a cationic molecular rotor dye, Thioflavin T (ThT) with three different sulfated cyclodextrin molecules, α-SCD, β-SCD and γ-SCD, which differ in their cavity size, using steady-state emission, ground-state absorption and time-resolved emission measurements. The obtained photophysical properties of ThT, upon interaction with different SCD molecules, indicate that the binding strength of ThT with different SCD molecules correlate with the cavity size of the host molecule, giving rise to the strongest complexation of ThT with the largest host molecule (γ-SCD). The binding affinity of ThT towards different host molecules has been supported by molecular docking calculations. The results obtained are further supported with the temperature and ionic strength dependent studies performed on the host-guest complex. Our results indicate that for host-induced guest aggregation, involving oppositely charged molecules, the size of the cavity also plays a crucial role beside the charge density on the exterior of host cavity.

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Natural and synthetic protein filaments in foodstuffs: Similarity and difference

Gao,

Cheng,

Zhang

et al. 2024

Food Hydrocolloids

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Effect of counter-anions on the aggregation of Thioflavin-T

Abstract: The aggregation of small molecules in aqueous solution is known to be influenced by the ionic strength of the medium, however, the role played by the identity of salt in...

Cited by 5 publications

References 72 publications

Non‐Globular Organic Ionic Plastic Crystal Containing a Crown‐Ether Moiety – Tuning Its Behaviour Using Sodium Salts

Non‐Globular Organic Ionic Plastic Crystal Containing a Crown‐Ether Moiety – Tuning Its Behaviour Using Sodium Salts

Guest Binding with Sulfated Cyclodextrins: Does the Size of Cavity Matter?

Natural and synthetic protein filaments in foodstuffs: Similarity and difference

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