Effect of cough on heart rate and blood pressure in patients with “cough syncope”

Benditt, David G.; Samniah, Nemer; Pham, Scott; Sakaguchi, Scott; Lü, Fei; Lurie, Keith G.; Ermis, Cengiz

doi:10.1016/j.hrthm.2005.04.022

Cited by 46 publications

(39 citation statements)

References 13 publications

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“…The traditional mechanism, loss of consciousness due to an increase in intrathoracic and/or cerebrospinal fluid pressure, is now regarded as inadequate [13]. A neural-mediated reflex, distinct from carotid sinus syndrome or vasovagal syncope, resulting in a vasodepressor-bradycardia and ensuing syncope has been implicated [14]. The findings of our study suggest that a similar syndrome may occur in asthma.…”

Section: To the Editormentioning

confidence: 67%

Autonomic dysregulation: a mechanism of asthma death

et al. 2014

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Section: To the Editormentioning

confidence: 67%

Autonomic dysregulation: a mechanism of asthma death

et al. 2014

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“…It seems likely that the real number of deaths due to cough syncope-related motor vehicle accidents is much more than is reported, particularly if it caused death of the driver, since in this case nobody can know what the cause of the accident was. The precise pathophysiologic mechanism of cough syncope is not fully understood, and remains a matter of debate [14][15][16][17][18][19][20]. Several mechanisms have been proposed in this regard.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, subjects susceptible for cough syncope exhibit greater hypotensive response to transient exaggerated intra-arterial pressure pulses. Both the magnitude and duration of the consequent hypotension are greater than in other fainters, and the hypotensive-triggered compensatory positive chronotropic response is absent or markedly suppressed [14,15]. Other suggested mechanisms indicates that the increased intra-thoracic pressure during coughing is transmitted to the cerebrospinal fluid, causing an acute pressure increase in the skull, compromising cerebral perfusion and resulting in syncope [16,21].…”

Section: Discussionmentioning

confidence: 99%

Recurrent Cough Syncope Due to Pertussis in Adults: Report of Three Cases and Review of the Literature

et al. 2016

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Cough syncope, also called "tussive syncope", is a well-recognized syndrome for about 70 years, in which loss of consciousness usually occurs immediately after a violent cough or prolonged bouts of violent coughing, lasting for seconds with rapid restoration of full consciousness. Its precise pathophysiologic mechanism is not fully understood and remains a matter of debate. Although pertussis is a frequent cause of prolonged cough in adults, still its burden in this age group is under-appreciated and under-diagnosed worldwide. This is well reflected by the fact that despite cough syncope is definitely not rare, until yet only six cases of cough syncope related to pertussis have been reported in the medical literature, one of them by us. We describe additional three adults with recurrent cough syncope due to pertussis who were diagnosed during a period of 3 months which completely resolved by treatment with azithromycin. Diagnosing four cases of cough syncope in adults due to pertussis during a short period in one Department of Internal Medicine, while only five cases were reported from the rest of the world, reflects the great lack of awareness on adult pertussis worldwide. Our four cases indicate that physicians should be much more aware of pertussis as a cause of cough and cough syncope in adults in order to terminate the attacks of cough and cough syncope and its serious complications by adequate antibiotic treatment, as happened with our four patients.

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“…The onset is rapid, duration is brief, and recovery is often spontaneous and complete. Cough syncope, which occurs immediately after coughing, is a well-recognized condition that has remained incompletely understood despite a number of studies examining its pathophysiology [10][11][12][13][14][15][16]. Several mechanisms have been suggested in this regard.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Cough Syncope Due to Pertussis in an Adult: A Case Report and Review of the Literature

Dawood¹,

Elias²,

Slobodin³

et al. 2015

J Med Cases

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Cough syncope is a well-recognized syndrome in which loss of consciousness usually occurs immediately after prolonged bouts of violent coughing lasting for seconds, with rapid and complete recovery of consciousness. Its pathophysiology is still incompletely understood. Although pertussis is a common cause of cough and cough syncope is not rare, to the best of our knowledge, only five cases of cough syncope related to pertussis have been previously reported, two of which are not well documented. We describe a 52-year-old male who presented to the emergency department with cough and recurrent episodes of cough syncope of 3 months duration due to pertussis which was completely resolved by treatment with azithromycin. Since pertussis is a common cause of subacute and chronic cough in adolescents and adults, and the clinical characteristics of pertussis among adults are less obvious than among children, it seems likely that cough syncope due to pertussis is underdiagnosed. It is important for the physicians to be aware of pertussis as a cause of chronic cough and cough syncope in adults in order to terminate the attacks by adequate antibiotic treatment.

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Effect of cough on heart rate and blood pressure in patients with “cough syncope”

Cited by 46 publications

References 13 publications

Autonomic dysregulation: a mechanism of asthma death

Autonomic dysregulation: a mechanism of asthma death

Recurrent Cough Syncope Due to Pertussis in Adults: Report of Three Cases and Review of the Literature

Recurrent Cough Syncope Due to Pertussis in an Adult: A Case Report and Review of the Literature

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