Effect of cosurfactant on the supramolecular structure and physicochemical properties of non-ionic biocompatible microemulsions

Resende, Kélia Xavier; Corrêa, Marcos Antônio; Oliveira, Anselmo Gomes de; Scarpa, Maria Virgínia

doi:10.1590/s1516-93322008000100005

Cited by 21 publications

(16 citation statements)

References 17 publications

(23 reference statements)

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“…Furthermore, co-surfactants can improve the solubility of the drug loaded into the system [62]. Ethanol also has a low topical toxicity and can be mixed with a wide range of surfactants, increasing the dissolving power of active compounds [63]. Multiple co-surfactants, when optimally selected, can act in conjunction to improve the overall flux of the drug without the need to add a permeation enhancer (PE) [64].…”

Section: Co-surfactantsmentioning

confidence: 99%

Nanoemulsion: A Review on Mechanisms for the Transdermal Delivery of Hydrophobic and Hydrophilic Drugs

et al. 2019

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Nanoemulsions (NEs) are colloidal dispersions of two immiscible liquids, oil and water, in which one is dispersed in the other with the aid of a surfactant/co-surfactant mixture, either forming oil-in-water (o/w) or water-in-oil (w/o) nanodroplets systems, with droplets 20–200 nm in size. NEs are easy to prepare and upscale, and they show high variability in their components. They have proven to be very viable, non-invasive, and cost-effective nanocarriers for the enhanced transdermal delivery of a wide range of active compounds that tend to metabolize heavily or suffer from undesirable side effects when taken orally. In addition, the anti-microbial and anti-viral properties of NE components, leading to preservative-free formulations, make NE a very attractive approach for transdermal drug delivery. This review focuses on how NEs mechanistically deliver both lipophilic and hydrophilic drugs through skin layers to reach the blood stream, exerting the desired therapeutic effect. It highlights the mechanisms and strategies executed to effectively deliver drugs, both with o/w and w/o NE types, through the transdermal way. However, the mechanisms reported in the literature are highly diverse, to the extent that a definite mechanism is not conclusive.

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Section: Co-surfactantsmentioning

confidence: 99%

Nanoemulsion: A Review on Mechanisms for the Transdermal Delivery of Hydrophobic and Hydrophilic Drugs

et al. 2019

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“…Nevertheless, excess amount of alcohol molecules replaces the surfactant molecules, thus, making the nanoemulsion droplets less stable. Furthermore, hydrogen binding between OH group of alcohol and polar chains of surfactant can occur, which lowers the fluidity of the interfacial film, making the preparation less stable (38). Additionally, alcohol molecules may enter the inner phase, which causes the expansion of the interfacial film, leading to size increase and instability (39).…”

Section: Discussionmentioning

confidence: 99%

Investigating the Parameters Affecting the Stability of Superparamagnetic Iron Oxide-Loaded Nanoemulsion Using Artificial Neural Networks

et al. 2012

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Abstract. Nanoemulsions are increasingly being investigated for their fascinating capability of loading both hydrophobic and hydrophilic molecules while their stability is still an issue, being affected by various factors. In this study, to evaluate the dominant factors affecting the stability of nanoemulsions, artificial neural networks (ANNs) were implemented. Nanoemulsions of almond oil in water containing oleic acidcoated superparamagnetic iron oxide nanoparticles were prepared using a mixture of Tween 80 and Span 80 as surfactant system and ethanol as a co-surfactant. The ratio of transparency of the samples at 30 min and 7 days after preparation was taken as an indication of the stability of samples. Four independent variables, namely, concentration of nanoparticle, surfactant, oil, and alcohol were investigated to find their relations with the dependent variable (i.e., transparency ratio). Using ANNs modeling, it was concluded that the stability is affected by all variables, with all variables showing reverse effect on the stability beyond an optimum amount.

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“…Too much interaction between surfactants and cosurfactants causes the interaction energy to decrease due to the self-association mechanism of intermolecular hydrogen bonds, which reduces the ability of OH alcohol groups to form hydrogen bonds with water. As a result, the dispersed ability will decrease [15].…”

Section: Formulation Optimizationmentioning

confidence: 99%

“…As a result, the droplet is damaged to smaller and uniform droplets. The beam of light passes through without a lot of scattering, and the transmittance is greater [15].…”

Section: Formulation Optimizationmentioning

confidence: 99%

Dissolution Enhancement of Tetrahydrocurcumin Using Optimized Self-Nanoemulsifying Drug Delivery System

Astuti¹,

Suliatin²,

Wahyuningrum³

2019

Int J App Pharm

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Objective: The objective of this study was to optimize and enhance the dissolution of tetrahydrocurcumin (THC) using optimized self-nanoemulsifyingdrug delivery system (SNEDDS).Methods: The optimization was carried out with the D-optimal design using software design expert 7.15. The independent variables were the amountof oil, surfactant, and cosurfactant. The dependent variables were the emulsification time, percentage transmittance, and dissolution efficiency atminute 15 (DE15). The dissolution profile of the THC in optimum formulation compared with the unmodified THC.Results: The optimum formulation of SNEDDS consists of 10% Labrafil, 80% Kolliphor:Labrasol (1:3), and 10% PEG 400. The DE15 was 49.45%,significantly higher than the THC unmodified (p<0.05). The estimated responses were not significantly different from the experimental responses.The droplet size of the optimum formula was 53.8 nm, the polydispersity index was 0.043 and the zeta value was -19.4 mV.Conclusion: The D-optimal design was successfully determining the optimum formula of THC loaded SNEDDS. The SNEDDS formulation wasincreased the dissolution of THC.

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Effect of cosurfactant on the supramolecular structure and physicochemical properties of non-ionic biocompatible microemulsions

Cited by 21 publications

References 17 publications

Nanoemulsion: A Review on Mechanisms for the Transdermal Delivery of Hydrophobic and Hydrophilic Drugs

Nanoemulsion: A Review on Mechanisms for the Transdermal Delivery of Hydrophobic and Hydrophilic Drugs

Investigating the Parameters Affecting the Stability of Superparamagnetic Iron Oxide-Loaded Nanoemulsion Using Artificial Neural Networks

Dissolution Enhancement of Tetrahydrocurcumin Using Optimized Self-Nanoemulsifying Drug Delivery System

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