EFFECT OF CORTISONE ON CALCIUM METABOLISM IN SARCOIDOSIS WITH HYPERCALCqMIA POSSIBLY ANTAGONISTIC ACTIONS OF CORTISONE AND VITAMIN D

Anderson, J.; Harper, Christine M.; Dent, C. E.; Philpot, G. R.

doi:10.1016/s0140-6736(54)90492-4

Cited by 208 publications

(36 citation statements)

References 11 publications

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“…However, the lyophilized samples of sera (unaltered sera was not available) from two such hypercalcemic infants tested by us contained normal quantities of antiricketic substance (side infra). Similar assay results were obtained with the sera from three patients having hypercalcemia in association with sarcoidosis, a disorder in which the suggestion of increased sensitivity to vitamin D has also been made (22,23).…”

Section: Resultssupporting

confidence: 71%

Studies of Antiricketic Activity in Sera From Patients With Disorders of Calcium Metabolism and Preliminary Observations on the Mode of Transport of Vitamin D in Human Serum*

Wc¹,

Hg²,

Tb³

et al. 1959

J. Clin. Invest.

102

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Section: Resultssupporting

confidence: 71%

Studies of Antiricketic Activity in Sera From Patients With Disorders of Calcium Metabolism and Preliminary Observations on the Mode of Transport of Vitamin D in Human Serum*

Wc¹,

Hg²,

Tb³

et al. 1959

J. Clin. Invest.

102

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“…Our observations are in accord with these findings. In contrast, in a patient with hypercalciuria due to sarcoidosis, a condition in which intestinal calcium hyperabsorption is well established (15,36,37), the response to a low calcium diet was similar to that of normals (14). It was also observed that patients with idiopathic hypercalciuria excreted during fasting 2-3 times more calcium in their urine than fasting normal controls.…”

Section: Resultsmentioning

confidence: 99%

Metabolic and calcium kinetic studies in idiopathic hypercalciuria

Liberman¹,

Sperling²,

Atsmon³

et al. 1968

J. Clin. Invest.

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A B S T R A C T Calcium balances and calcium kinetic studies using 47Ca were performed in nine male patients with idiopathic hypercalciuria and in three normal male subjects. A sharp reduction in calcium intake in eight patients with idiopathic hypercalciuria caused a decrease in urinary calcium excretion, the latter remaining elevated above that reported for normal subjects on a low calcium diet. The hypercalciuric patients had an enlarged miscible calcium pool size, an increased calcium turnover rate, increased bone formation and bone resorption rates, and an elevated true intestinal calcium absorption rate, the increase of the latter three parameters being proportional to the increase of the turnover rate. The fraction of the calcium turnover rate excreted in the urine was elevated whereas that constituted by the endogenous fecal calcium excretion was decreased. Arguments are presented for the concept that the primary abnormality in idiopathic hypercalciuria is neither renal calcium hyperexcretion nor intestinal calcium hyperreabsorption, but a more fundamental disturbance in calcium metabolism of as yet unknown cause, leading to a high calcium turnover.

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“…In certain patients with sarcoidosis, there may be a defect in calcium metabolism due to excesive intestinal absorption of the cation (7)(8)(9). This abnormality, correctable by glucocorticoid administration (7)(8)(9), may result from increased amounts of circulating vitamin D (8) or an increased sensitivity to its effects (7,9).…”

Section: Introductionmentioning

confidence: 99%

“…This abnormality, correctable by glucocorticoid administration (7)(8)(9), may result from increased amounts of circulating vitamin D (8) or an increased sensitivity to its effects (7,9). Glucocorticoids may also lower the serum calcium in patients with vitamin D intoxication (10,11), at least in part, by reducing the intestinal absorption of calcium.…”

Section: Introductionmentioning

confidence: 99%

Effect of cortisone treatment on the active transport of calcium by the small intestine

Kimberg¹,

Baerg²,

Gershon³

et al. 1971

J. Clin. Invest.

260

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A B S T R A C T It is generally recognized that glucocorticoid administration may diminish calcium absorption in vivo as well as the active transport of calcium by the intestine in vitro. Recent studies by others have emphasized the possibility of an alteration in the metabolism of vitamin D to 25-hydroxycholecalciferol in accounting for the steroid effects on calcium absorption. The results obtained in the present studies fail to support this hypothesis.The present studies confirm that the administration of cortisone or other glucocorticoids to the rat interferes with the active transport of calcium by duodenal gut sacs in vitro. This abnormality is not due to an alteration in the permeability of the intestine to calcium, and it cannot be corrected by the administration of either massive doses of vitamin D3 or modest doses of 25-hydroxycholecalciferol. Experiments concerned with the effects of cortisone on the level of the vitamin D-dependent duodenal calcium-binding protein, the amount of bioassayable vitamin D activity in the mucosa, and the distribution and metabolism of 'H-vitamin D3, did not provide evidence in favor of a hormone-related defect in either the localization of vitamin D or its metabolism to 25-hydroxycholecalciferol. Alterations in the transport of iron and D-galactose, not dependent on vitamin D, suggest that cortisone treatment may be responsible for more than a simple antagonism to the effects of vitamin D.The results of the present studies indicate that cortisone administration affects the cellular mechanisms mediating calcium transport in a manner that is opposite to the

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EFFECT OF CORTISONE ON CALCIUM METABOLISM IN SARCOIDOSIS WITH HYPERCALCqMIA POSSIBLY ANTAGONISTIC ACTIONS OF CORTISONE AND VITAMIN D

Cited by 208 publications

References 11 publications

Studies of Antiricketic Activity in Sera From Patients With Disorders of Calcium Metabolism and Preliminary Observations on the Mode of Transport of Vitamin D in Human Serum*

Studies of Antiricketic Activity in Sera From Patients With Disorders of Calcium Metabolism and Preliminary Observations on the Mode of Transport of Vitamin D in Human Serum*

Metabolic and calcium kinetic studies in idiopathic hypercalciuria

Effect of cortisone treatment on the active transport of calcium by the small intestine

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