Effect of cortisone and ACTH on fluid and electrolyte distribution in man

Levitt, Marvin F.; Bader, Mortimer E.

doi:10.1016/0002-9343(51)90022-8

Cited by 65 publications

(26 citation statements)

References 32 publications

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“…tran (10). In addition, cortisone therapy has been reported to cause an increase in extracellular volume (30,31) even in the absence of weight gain (30). Thus it may be suggested that, following cortisone administration, there might have been a reversal of the elevated extravascular colloid concentration postulated under dextran administration, with a resultant augmented stimulus for albumin production.…”

Section: Discussionmentioning

confidence: 99%

Studies on Albumin Synthesis: The Effects of Dextran and Cortisone on Albumin Metabolism in Rabbits Studied With Albumin-I131*

Rothschild¹,

Oratz²,

Wimer³

et al. 1961

J. Clin. Invest.

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Following plasmapheresis, the depressed serum albumin concentration rapidly returns to normal (1) indicating alterations in albumin synthesis or degradation. Both dextran administration (2-6) and elevation of serum globulin levels produced by means of hyperimmunization (7,8) are associated with hypoalbuminemia; a colloid osmotic regulatory mechanism has been suggested as responsible for the reciprocal changes in serum proteins observed after hyperimmunization (7, 9). If such a mechanism does exert control over the concentration of serum albumin, alterations of albumin metabolism either in the rate of synthesis or in the rate of degradation might be expected when osmotically active molecules other than albumin are added to the circulation. The present study represents an attempt to define, more specifically than heretofore reported, the changes in albumin metabolism resulting from such a procedure. Dextran was administered to rabbits to depress albumin concentration. After the development of hypoalbuminemia, the rates of albumin synthesis and degradation were studied and compared with control values. Cortisone acetate was then given to increase the rate of albumin degradation (10), and the rates of albumin synthesis were remeasured. METHODSFemale rabbits were used in all studies. Animals were kept in metabolism cages and fed a standard rabbit diet.

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Section: Discussionmentioning

confidence: 99%

Studies on Albumin Synthesis: The Effects of Dextran and Cortisone on Albumin Metabolism in Rabbits Studied With Albumin-I131*

Rothschild¹,

Oratz²,

Wimer³

et al. 1961

J. Clin. Invest.

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“…There was a large but transient loss of potassium within 24 hours after the beginning of treatment and a corresponding retention of potassium at the beginning of the postcorticotropin period. A transient increase in the inulin space in patients treated with corticotropin and cortisone, and maintained on rigid salt restriction, has been reported by Levitt and Bader (3). Since the patients studied by these authors were on a markedly restricted salt intake and remained in salt balance, without gain in weight, it was concluded that the observed increase in the extracellular fluid volume was due to a shift of salt and water from the intracellular compartment.…”

mentioning

confidence: 64%

Effects of Corticotropin on Body Water and Electrolytes in Patients With Rheumatic Disease 1

Deane¹,

Ziff²,

Bunim³

1953

J. Clin. Invest.

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The therapeutic response to pituitary adrenocorticotropic hormone is often accompanied by profound changes in water, solid, and electrolyte distribution. Metabolic balance studies in patients receiving corticotropin (1) have demonstrated marked initial retention of sodium and chloride and subsequently increased excretion of these ions while potassium balance remained negative. Bartter and his co-workers (2), studying patients with panhypopituitarism who were receiving corticotropin, observed that retention of sodium was greater than that of chloride, and concluded that sodium entered cells when corticotropin was given, and left the cells during the recovery periods. There was a large but transient loss of potassium within 24 hours after the beginning of treatment and a corresponding retention of potassium at the beginning of the postcorticotropin period. A transient increase in the inulin space in patients treated with corticotropin and cortisone, and maintained on rigid salt restriction, has been reported by Levitt and Bader (3). Since the patients studied by these authors were on a markedly restricted salt intake and remained in salt balance, without gain in weight, it was concluded that the observed increase in the extracellular fluid volume was due to a shift of salt and water from the intracellular compartment. Recently, Ziff, Simson, and Bunim (4) reported variation in the manner of water re-

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“…), like TJ-801 4, prevented the decrease in the RBF in rats with APHN. In this connection, chronic administration of pharmacological doses of glucocorticoids such as cortisone, hydrocortisone and prednisolone has been indicated to increase glomerular filtration rate in dog, rat and man (17)(18)(19). It is postulated from these results that TJ-8014 may exert its antinephritic action by eliminating the glomer ular subepithelial immune deposits and MAC through the increase in the RBF mediated by endogenous corticosterone.…”

Section: Discussionmentioning

confidence: 99%

Studies on Antinephritic Effect of TJ-8014, a New Japanese Herbal Medicine (4): Effects on Accelerated Passive Heymann Nephritis in Rats

Hattori

Ito

Suzuki

1990

Japanese Journal of Pharmacology

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Abstract-We investigated the antinephritic effect of TJ-8014, in comparison to dipyridamole, on accelerated passive Heymann nephritis in rats. TJ-8014 (4.0 g/ kg/day, p.o.) given from the heterologous phase (from the day of injection of the antiserum against Fx1 A) markedly inhibited the urinary protein excretion and the elevation of plasma cholesterol levels as well as glomerular histopathological changes.When the treatment was started from the autologous phase (from the 22nd day) after proteinuria was fully developed, TJ-8014 also showed a beneficial effect. Dipyridamole (0.4 g/kg/day, p.o.) had no effect when the treatment was started either from the heterologous or autologous phase. TJ-8014 decreased glomerular rat IgG and rat C3 deposits, although it affected neither the plasma antibody titer against rabbit r-globulin nor the plasma complement level. TJ-8014 markedly prevented the reduction of plasma and adrenal corticosterone level as well as the reduction of renal blood flow of rats with nephritis.These results suggest that TJ-801 4 may be a useful drug against idiopathic membranous nephro pathy and the beneficial effect of this drug may be caused by the elimination of glomerular immune deposits and C3 through the increase in renal blood flow related to the enhanced release of adrenal corticosterone.

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Effect of cortisone and ACTH on fluid and electrolyte distribution in man

Cited by 65 publications

References 32 publications

Studies on Albumin Synthesis: The Effects of Dextran and Cortisone on Albumin Metabolism in Rabbits Studied With Albumin-I131*

Studies on Albumin Synthesis: The Effects of Dextran and Cortisone on Albumin Metabolism in Rabbits Studied With Albumin-I131*

Effects of Corticotropin on Body Water and Electrolytes in Patients With Rheumatic Disease 1

Studies on Antinephritic Effect of TJ-8014, a New Japanese Herbal Medicine (4): Effects on Accelerated Passive Heymann Nephritis in Rats

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