Effect of Corticotrophin on Plasma Levels of Human Growth Hormone

Zahnd, G; Nadeau, André; Mühlendahl, Karl-E. Von

doi:10.1016/s0140-6736(69)90812-5

Cited by 34 publications

(14 citation statements)

References 10 publications

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“…Contrary to our speculation, HGH secretion occurred following the administration of 50022-S. Already, Zahnd (1969), Neri (1970 and Tsuji (1969) reported that HGH was secreted in response to ACTH. Zahnd et al(1969) suggested that ACTH might mediate the increase in HGH which followed insulininduced hypoglycemia, because ACTH stimulated HGH secretion similarly as insulininduced hypoglycemia did in six subjects.…”

Section: Discussioncontrasting

confidence: 83%

“…Already, Zahnd (1969), Neri (1970 and Tsuji (1969) reported that HGH was secreted in response to ACTH. Zahnd et al(1969) suggested that ACTH might mediate the increase in HGH which followed insulininduced hypoglycemia, because ACTH stimulated HGH secretion similarly as insulininduced hypoglycemia did in six subjects. Neri et al(1970), however, observed that there was no increase in HGH after the administration of 1-24 ACTH in 2 of 8 subjects who had normal HGH response to insulininduced hypoglycemia and they suggested that the HGH response to hypoglycemia could occur independently of ACTH, though ACTH probably had some influence on HGH secretion.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, there are a few reports concerning HGH secretion following the administration of corticotropin (Zahnd et al, 1969, Neri et al, 1970, Tsuji et al, 1969, Del Guercio et al, 1971, Byyny et al, 1972.…”

Section: Synopsismentioning

confidence: 99%

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Effect of Synthetic Corticotropins on Human Growth Hormone Secretion

1973

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SynopsisHuman growth hormone (HGH) secretion occurred following the administration of Gly1--ACTH (1-18) octadecapeptide amide (50022-S) which was synthetized by Otsuka.The mean response curve of plasma HGH after the intravenous administration of 0.35mg of 50022-S in 23 healthy subjects was similar to that of plasma cortisol.A significant increase in plasma HGH to 0.35mg of 50022-S was observed, while there was no significant increase in plasma HGH to 0.25 mg of 1-24 ACTH, which is a corresponding dose to 0.35mg of 50022-S in cortisol response.In most of the patients who had dysfunction of hypothalamic-pituitary axis, no significant increase in plasma HGH to 0.35mg of 50022-S was observed.From these results, we conclude that Gly'-ACTH (1-18) octadecapeptide amide (50022-S) has a potency to release growth hormone from the pituitary in man.

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Section: Discussioncontrasting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Effect of Synthetic Corticotropins on Human Growth Hormone Secretion

1973

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“…This may also exclude the possibility that an increase in endogenous ACTH stimulates GH release, though Zahnd et al(1969) (Berson and Yalow, 1968) or longer (Berson and Yalow, 1968;Liddle et al, 1962;Strott et al, 1969;Jubiz et al, 1970a, and b) to stimulate the release of ACTH by a negative feedback mechanism. Therefore, the of metyrapone may not be caused by the negative feedback mechanism.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Determinations of Plasma ACTH and GH Levels after an Oral Metyrapone

et al. 1972

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“…There are various methods as provocative tests for HGH secretion, including the use of insulin (Roth et al, 1963), arginine (Merimee et al, 1965), glucagon (Mitchell et al, 1969), levodopa (Boyd et al, 1970), ACTH (Zahnd et al, 1969) and metyrapone (Kunita et al, 1970 The mechanism of glucagon stimulated HGH secretion is still unclear. In order to investigate whether the stimulatory effect of glucagon on HGH release may be associated with plasma IRG level itself, plasma IRG levels were measured during glucagon injection in the present experiment.…”

Section: Discussionmentioning

confidence: 99%