Effect of Corticotrophin and Cortisone on the Blood in Various Disorders in Man

Mechanism of Prednisolone-Induced Leucocytosis in Man

“…It is commonly known that AGTH, cortisone and metisteroids, among others, produce leucocytosis and neutrophilia (7,9,10,17). This effect is thought by Shen and H oshino (11) to be initiated by a mobilization of leucocyte depots.…”

Research at the heart of hematology: thrombocytopenias and platelet function disorders

“…6 In the same year, Evans hypothesized that the ITP had an immune genesis, 7 paving the way to immunosuppressants as an effective treatment for this disorders. 8 Finally, the search for the humoral substance responsible for causing the platelet count to rise in response to thrombocytopenia, which had involved many groups of researchers for many decades, led in 1994 to the purification and cloning of thrombopoietin (TPO). 9 This achievement opened the way to the development of TPO mimetics, which have proven effective not only in ITP, but also in other forms of thrombocytopenia and in bone marrow aplasia.…”

Maxwell Wintrobe, in his own words

“…The use of nitrogen mustard as a chemotherapy agent has been mentioned. Wintrobe also embarked on a number of studies of the newly discovered agents, corticotrophin and cortisone, observing, on the one hand, adverse effects in acute myelogenous leukaemia and, on the other, amelioration of pernicious anaemia; an observation that antedated the discovery that this genetically determined illness had an immunological basis (Wintrobe et al , 1951). This period also saw the seminal studies of the pathophysiology of the anaemia of chronic disease, predicting the multiple components involved in the pathogenesis of this syndrome.…”