Effect of corticosterone on developing hippocampus: Short‐term and long‐term outcomes

Wang, He; Zhao, Ming; Machida, Takeo; Chen, Nai‐Hong

doi:10.1002/hipo.20523

Cited by 6 publications

(4 citation statements)

References 51 publications

(58 reference statements)

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“…In adults, and rodent models, depression is associated with decreased neurogenesis in dentate gyrus and increased plasma glucocorticoid formation (Manji et al, 2001; Sapolsky, 2001). Early corticosterone exposure is necessary for dentate gyrus development of rodents and species-typical cognitive function (He et al, 2009) and glucocorticoid production from the adrenals promotes cell survival in the brain. Indeed, removal of the adrenals in rats increases cell death in the granule layer and dentate gyrus of the hippocampus (Frye and McCormick, 2000a,b; Rhodes et al, 2004).…”

Section: Neurodevelopmental Neuropsychiatric and Neurodegenerative mentioning

confidence: 99%

Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review

et al. 2011

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Maternal–offspring interactions begin prior to birth. Experiences of the mother during gestation play a powerful role in determining the developmental programming of the central nervous system. In particular, stress during gestation alters developmental programming of the offspring resulting in susceptibility to sex-typical and stress-sensitive neurodevelopmental, neuropsychiatric, and neurodegenerative disorders. However, neither these effects, nor the underlying mechanisms, are well understood. Our hypothesis is that allopregnanolone, during gestation, plays a particularly vital role in mitigating effects of stress on the developing fetus and may mediate, in part, alterations apparent throughout the lifespan. Specifically, altered balance between glucocorticoids and progestogens during critical periods of development (stemming from psychological, immunological, and/or endocrinological stressors during gestation) may permanently influence behavior, brain morphology, and/or neuroendocrine-sensitive processes. 5α-reduced progestogens are integral in the developmental programming of sex-typical, stress-sensitive, and/or disorder-relevant phenotypes. Prenatal stress (PNS) may alter these responses and dysregulate allopregnanolone and its normative effects on stress axis function. As an example of a neurodevelopmental, neuropsychiatric, and/or neurodegenerative process, this review focuses on responsiveness to drugs of abuse, which is sensitive to PNS and progestogen milieu. This review explores the notion that allopregnanolone may effect, or be influenced by, PNS, with consequences for neurodevelopmental-, neuropsychiatric-, and/or neurodegenerative- relevant processes, such as addiction.

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Section: Neurodevelopmental Neuropsychiatric and Neurodegenerative mentioning

confidence: 99%

Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review

et al. 2011

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“…70 Decreased exercise is the second major factor involved in obesity development and might, therefore, play a role in the decline in memory performance of older obese people. All of these environmental conditions can have strong, long-lasting effects when they occur during early developmental stages (e.g., during fetal programming and early postnatal weeks of life in humans 71,72 and animals [73][74][75][76][77][78][79][80][81][82][83] ).…”

Section: Introductionmentioning

confidence: 99%

Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

Beck

Pourié

2013

Nutr Rev

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The hippocampus is a brain region of primary importance for neurogenesis, which occurs during early developmental states as well as during adulthood. Increases in neuronal proliferation and in neuronal death with age have been associated with drastic changes in memory and learning. Numerous neurotransmitters are involved in these processes, and some neuropeptides that mediate neurogenesis also modulate feeding behavior. Concomitantly, feeding peptides, which act primarily in the hypothalamus, are also present in the hippocampus. This review aims to ascertain the role of several important feeding peptides in cognitive functions, either through their local synthesis in the hippocampus or through their actions via specific receptors in the hippocampus. A link between neurogenesis and the orexigenic or anorexigenic properties of feeding peptides is discussed.

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“…High levels of corticosterone inhibit neuronal growth and function via the GR (Sousa et al, 1999(Sousa et al, , 2008Cerqueira et al, 2005), while moderate levels of corticosterone enhance neuronal growth and function via the MR (Woolley et al, 1991;Diamond et al, 1992;Pavlides et al, 1995;Takahashi and Goh, 1998;Scaccianoce et al, 2001;He et al, 2009). Thus, corticosterone may play a direct role in song development and maintenance by binding to receptors in song nuclei.…”

Section: Corticosterone Receptors Expressed In the Song Systemmentioning

confidence: 99%

Complex Song Development and Stress Hormone Levels in the Bengalese Finch

Suzuki

Matsunaga

Yamada

et al. 2014

Avian Biology Research

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Models of birdsong are useful in the study of developmental and evolutional mechanisms of vocal learning behaviour. Knowledge of these mechanisms is important for understanding the evolutionary adaptation strategies of organisms. The Bengalese finch sings a complex song believed to have evolved by domestication because the song of its wild ancestor, the white-backed munia, was very simple. There is evidence that the song complexity is used as an indicator of male quality during mate selection. Because songbirds learn their song as juveniles, development of the song system is affected by developmental stress. Therefore, song traits may reflect developmental conditions and that may be honest sexually selected signals. We compared the level of the stress hormone corticosterone between Bengalese finches and white-backed munias. Results showed that Bengalese finches had lower circulating corticosterone levels than white-backed munias. Relaxation from natural selection pressures and the addition of artificial selection due to domestication may have decreased the corticosterone levels and allowed for the evolution of the complex song in the Bengalese finch. Two subtypes of corticosterone receptors, the glucocorticoid receptor and mineralocorticoid receptor, showed expression in song nuclei of the Bengalese finch brain. Thus, these results suggest the possibility that song development is regulated by corticosterone via binding to the corticoid receptors. Song-nuclei-related expression of corticoid receptors might have had an increasing developmental condition-dependent influence on song traits. Thus, our results suggest that decreased stress hormone levels secondary to domestication might account for one reason why songs became complex in Bengalese finches.

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Effect of corticosterone on developing hippocampus: Short‐term and long‐term outcomes

Cited by 6 publications

References 51 publications

Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review

Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review

Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

Complex Song Development and Stress Hormone Levels in the Bengalese Finch

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