Effect of coronary revascularization on serum collagen biomarkers and left ventricular remodeling in patients with acute myocardial infarction

Ren, Huajian; Wang, Lexin

doi:10.1016/j.hrtlng.2011.09.013

Cited by 2 publications

(6 citation statements)

References 14 publications

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“…Primary coronary revascularization within 6 h of MI was associated with a greater reduction of PICP than the revascularization performed more than 12 days after the MI (ref. 9 ). However, the early coronary revascularization was not associated with a greater reduction in serum PIIINP (ref.…”

Section: Discussionmentioning

confidence: 99%

“…However, the early coronary revascularization was not associated with a greater reduction in serum PIIINP (ref. 9 ). A recent study on 233 patients with acute MI also failed to show any longitudinal changes or predictive values of serum PIIINP (ref.…”

Section: Discussionmentioning

confidence: 99%

“…Several earlier clinical observations in a small number of patients have found that coronary revascularization with PCI or thrombolytic therapy within the first 12 h of symptom onset diminished MI-induced PICP or PIIINP elevation 8,9 . Although the reduction in PICP or PIIINP may represent less ventricular remodeling or dysfunction, the predictive value of post-PCI PICP and PIIINP on left ventricular function remains controversial 8,9 .…”

Section: Introductionmentioning

confidence: 92%

“…Coronary angiography was performed through the right femoral approach. Stent (drug-eluting stent or bare metal stent) was implanted and direct stenting was allowed if suitable culprit lesion was visualized 6,9 . Success of PCI was defined as TIMI flow grade 2 or 3 and residual stenosis < 50% at the culprit coronary artery.…”

Section: Study Protocolmentioning

confidence: 99%

“…Although the reduction in PICP or PIIINP may represent less ventricular remodeling or dysfunction, the predictive value of post-PCI PICP and PIIINP on left ventricular function remains controversial 8,9 . In the present study, we investigated the relations between post-PCI levels of serum PICP and PIIINP and the clinical outcome in patients with STEMI.…”

Section: Introductionmentioning

confidence: 99%

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Predictive value of serum collagen biomakers on the outcome of acute myocardial infarction treated with percutaneous coronary intervention

Gao¹,

Zhao²,

Ma³

et al. 2015

BIOMED PAP

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Aims. This study was designed to investigate the predictive value of serum collagen biomarkers on the outcomes of acute ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI). Methods. Two hundred and ten patients with STEMI were successfully treated with PCI within 6 hrs ofthe onset of chest pain. The levels of serum procollagen type I carboxyterminal peptide (PICP) and procollagen type III peptide (PIIINP) were measured by enzymelinked immunosorbent assay (ELISA) before, 3 and 6 months after PCI. Left ventricular ejection fraction was assessed by echocardiography at 3 and 6 months after PCI. The composite endpoints were death by any cause, recurrent myocardial infarction, heart failure or stroke. Results. At the end of the 12-month follow up, 29 patients (13.8%) experienced an end point. The level of serum PICP in patients with an end point was higher than in patients without an end point 7 days (19.45 ± 2.17 vs 14.95 ± 3.07 ng/ mL, P<0.05) or 3 month after the PCI (29.87 ± 3.02 vs 22.14 ± 3.33 ng/mL, P<0.05). The serum PIIINP level in patients with an end point was also higher than those without 7 days after PCI (59.34 ± 4.23 vs 48.78 ± 4.23 ng/mL, P<0.05). Multivariate logistic regression analysis showed day 7 (OR=2.170, 95% CI 1.583-4.345, P=0.01) and 3-month serum PICP (OR=2.340, 95% CI 1.431-4.650, P=0.01) were independent predictors of composite end points. Conclusions. Persistent elevation of serum collagen marker PICP three months after PCI predicts an adverse outcome for patients with acute ST-elevation myocardial infarction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%