Effect of core body temperature on ventilator-induced lung injury

Abstract

In two studies of ventilator-induced lung injury in rabbits, maintaining hyperthermia compared with hypothermia augmented the development of lung injury. Similar results from both the in vivo and isolated, perfused lung studies suggest that the observed effects were not due to cardiovascular factors or consequences of heating nonpulmonary organs.

Effect of Therapeutic Hypothermia on Gas Exchange and Respiratory Mechanics: A Retrospective Cohort Study

“…Hypothermia has been shown to attenuate ischemia-reperfusion lung injury (Shoji et al, 2005;Zhang et al, 2006;Chang et al, 2008) and ventilator-induced lung injury (Lim, 2003a;Suzuki et al, 2004;Morita et al, 2009;Cruces et al, 2011;Aslami et al, 2012). Moreover, animal literature shows a consistent protective effect of hypothermia on toxin-induced lung injury (Lim, 2003b;Scumpia et al, 2004;Chin et al, 2007;Jo et al, 2011) and pneumonia .…”

Effects of different mechanical ventilation strategies on the mucociliary system

“…Moreover, the effects of oxygen toxicity in tracheal cells have been observed only after 24 h of exposure to 80% oxygen [31]. Normothermia and hypothermia, in contrast to hyperthermia, have not been shown to increase the detrimental effects of mechanical ventilation on the lung [41].…”

Pretreatment with atorvastatin attenuates lung injury caused by high-stretch mechanical ventilation in an isolated rabbit lung model

“…In addition, 40 mL of autologous blood collected earlier was added in the perfusate to serve as a marker of vascular damage. Thus, the total volume in the circuit was 390 mL, the perfusate hematocrit was approximately 3%, and the white blood cell count was negligible (22,23). The perfusate pH and arterial carbon dioxide tension (PaCO 2 ) were controlled through insufflation of a gas mixture of carbon dioxide (35% to 45%) and room air (65% to 55%) into the perfusate during the whole experiment.…”