Effect of Cordyceps Sinensis on Uncoupling Protein 2 in Experimental Rats with Nonalcoholic Fatty Liver

The objective of the present study is to evaluate the effect of the extract of a well-known hepatospecific polyherbal formulation, Liv.52, in an experimental model of high-fat diet (HFD)-induced nonalcoholic steatohepatitis (NASH) in rats. Feeding a HFD for 15 weeks resulted in significant impairment of the lipid profile, elevation of hepatic enzyme markers, and insulin resistance in rats. The histological examination of the liver furthermore indicated fibrotic changes and fat deposition in hepatic tissues. The treatment with Liv.52 extract [125 mg/kg body weight per os (b.wt. p.o.)], which was administered from week 9 onward, reversed the HFD-induced changes to a statistically significant extent, compared to the untreated positive control animals. The effect observed with Liv.52 extract was comparable to that of pioglitazone (4 mg/kg b.wt.), a standard drug that is useful in the management of NASH. The treatment with Liv.52 extract significantly reduced steatosis, collagen deposition, and necrosis in hepatic tissues, which indicates its antifibrotic and antinecrotic properties. The results obtained in the present set of experiments indicate that Liv.52 extract effectively reverses metabolic and histological changes associated with HFD-induced NASH.

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“…The HFD consisted of 87.5% normal laboratory rodent feed, 10% animal fat, 0.5% cholic acid, and 2% cholesterol. 14 …”

Section: Methodsmentioning

confidence: 99%

Extract of a polyherbal formulation ameliorates experimental nonalcoholic steatohepatitis

Azeemuddin¹,

Rafiq²,

Anturlikar³

et al. 2016

Journal of Traditional and Complementary Medicine

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“…13 One study evaluated ATP levels and mitochondrial uncoupling protein 2 (UCP2) expression in the liver of rats fed a HFD for up to 20 weeks. In this model, supplementation with O. sinensis 73 prevented ATP depletion and kept UCP2 levels elevated in comparison with control animals (Figure 2). Isolated polysaccharides from G. lucidum (GLP) inhibited mitochondrial-related apoptosis in HFD-fed mice splenic lymphocytes, demonstrated by a decrease in the Bax/Bcl-2 ratio and suppression of caspase-3 activation.…”

Section: Box 3 Edibility Consumption and Health Benefits Of Mushrooms...mentioning

confidence: 83%

Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets

Fontes

Ramalho‐Santos

Zischka

et al. 2021

Eur J Clin Investigation

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Food and diet shaped human and nature histories. From the hunter-gathering communities to cooking with fire, to domesticating animals, planting crops and urbanization, to industrial revolutions, and to artificial intelligence, dietary habits influence human metabolism and consequently the condition of health and disease.Dietary habits from the Neolithic to the present, and the accompanying food production and processing procedures, have introduced some critical alterations in nutritional status, concerning glycaemic load, fatty acid, macronutrient, micronutrient or fibre content, acid-base balance, or sodium-potassium ratio, 1 leading to major shifts in metabolism traits. Although they also include heritable components, some of those traits like the high risk for obesity, 2 or non-alcoholic fatty liver disease (NAFLD) 3,4 (See Box 1), 4 a most important cause of liver disease, can be heavily affected by diet and other lifestyle conditions (e.g., sedentarism and sleep deprivation).Actually, over the last four decades, the rapid environmental changes contributed to the increase in mean body-mass index (BMI) and obesity, including among young people (ages 5 to 19 years) in most regions, 5 with important implications for public and global health.Dietary risk factors exacerbate metabolic risk factors 6 and the non-communicable diseases (NCD) mortality and morbidity, 7 that is, cardiovascular diseases (CVD), excess weight, obesity, type II diabetes mellitus (T2DM), cancer, neurodegenerative disorders and NAFLD. In 2017, around 22% of all deaths from NCD, among adults, were associated with dietary risk factors, representing a higher mortality risk than any other cause 7 ; such dietary risk factors include high levels of trans fat, sugary drinks, and high levels of red and processed meats, and vice versa, too low amounts of fruits, legumes, whole grains, nuts and seeds. 7 In 2018, the WHO estimated that NCD caused 71% of all deaths globally (41 million people per year). 8 Diet quality should cover variety and diversity, adequacy, moderation and balance; still, there are major gaps about defining diet quality, metrics for monitoring diet quality, and/or for diet quality monitoring in global

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“…On the other hand, OS supplementation on HFDfed rats can enhance the protein expression of uncoupling protein 2 (UCP-2), further increasing energy expenditure in electronic transport chain, and then attenuate the steatosis [42]. The UCP-2 was considered as an important therapeutic target in NAFLD [43], and many pharmacological researches had focused on related mechanisms to restore the lipid homeostasis [27,42,43,44]. Overall, the OSM or its metabolites may modulate the whole body lipid regulation.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effects of Ophiocordyceps sinensis Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Chou¹,

Lin²,

Wu³

et al. 2017

JFNR

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Dyslipidemia is regarded as one of risk factors related to cardiovascular disease and hepatosteatosis widely. Due to westernized diet habits and lifestyle changes, there is a high prevalence of those lipid-dysregulated diseases, i.e. fatty liver, hyperlipidemia, diabetes etc. However, the liver holds the lipid homeostasis so hepatoprotective nutraceuticals against high-fat diet (HFD) induced dyslipidemia may be potential for a public demand. This study demonstrated that OSM containing 10% polysaccharides and 0.25% adenosine can decrease (p<0.05) serum and liver triglyceride (TG) contents, and meanwhile, increased (p<0.05) fecal cholesterol (TC) levels in HFD fed mice. Moreover, Ophiocordyceps sinensis mycelium (OSM) also decreased (p<0.05) serum low-density lipoprotein cholesterol (LDLC) levels and the atherosclerosis index (LDLC/high-density lipoprotein cholesterol (HDLC)) in HFD fed mice. Regarding the liver damage, OSM supplementation attenuated serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values, and liver tumor necrosis factor-α (TNF-α) levels in HFD fed mice. Taken together, OSM showed an ameliorative effect of the hepatosteatosis development and lipid-dysregulated-related diseases in a HFD habit.

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Effect of Cordyceps Sinensis on Uncoupling Protein 2 in Experimental Rats with Nonalcoholic Fatty Liver

Cited by 3 publications

References 21 publications

Extract of a polyherbal formulation ameliorates experimental nonalcoholic steatohepatitis

Extract of a polyherbal formulation ameliorates experimental nonalcoholic steatohepatitis

Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets

Preventive Effects of <i>Ophiocordyceps </i><i>s</i><i>inensis </i>Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

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