Effect of Cooling on the Power of Voluntary and Electrically Stimulated Contractions of the Lower Limb Extensors

Skelton, Dawn A.; Aston, H; Greig, CA; Young, Alexandra L.

doi:10.1042/cs083016p

Cited by 2 publications

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“…For completeness, it should be noted that the reduction in explosive power can be aggravated further by a reduction in the intrinsic`speed' of the muscle, as a result of cooling Davies & Young 1983;Skelton et al 1992) (e.g. in those elderly people who are immobile, thin and living in poorly heated accommodation), and as a result of a change in the isoforms of myosin expressed in older human muscle (discussed elsewhere (Harridge & Young 1997) Figure 2.…”

Section: M U S C U L a R C Ac H E X I A Of Ag E I Ngmentioning

confidence: 99%

Ageing and physiological functions

Young

1997

Phil. Trans. R. Soc. Lond. B

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In youth, most physiological functions have generous spare capacity. Even in health, however, increasing age is characterized by progressive erosion of these ‘safety margins’. Examples include the decline of bone mass (towards a threshold for likelihood of fracture), of glomerular filtration rate (towards a threshold for susceptibility to clinical renal failure), of renal tubular function (towards a threshold for clinically important susceptibility to dehydration), of hepatic function (towards a thresholds for accumulation following conventional ‘young adult’ doses of common medications), or of lower limb explosive power (towards thresholds for impaired functional mobility). Increasing age is also characterized by a rising prevalence of chronic pathologies, complicating attempts to determine the rate or the mechanism of the age–related decline in a physiological function. Nevertheless, it is clear that in many organs the loss of function is largely attributable to the loss of functioning cells, even in the absence of overt disease. This apparently fundamental aspect of ageing remains poorly understood.

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Section: M U S C U L a R C Ac H E X I A Of Ag E I Ngmentioning

confidence: 99%