Effect of Contrast Material, Hypercapnia, Hyperventilation, Hypertonic Glucose and Papaverine on the Diameter of the Cerebral Arteries

Huber, Peter M.; Handa, Jyoji

doi:10.1097/00004424-196701000-00016

Cited by 363 publications

(150 citation statements)

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“…These assumptions have been confirmed recently by Giller and colleagues who observed during operation that the diameter of the proximal MCA does not dilate more than 4 % during variations in Pa CO2 or arterial pressure, nor does it change appreciably with systemic administration of nitroprusside or phenylephrine [20]. The lack of change in diameter with change in Pa cc , 2 has also been reported previously by Huber and Handa [21]. If we accept the assumption that the MCA region that TCD insonates does not change in diameter, then the change in blood flow velocity is proportional to changes in CBF.…”

Section: Discussionsupporting

confidence: 68%

Cerebral Pressure Autoregulation and Carbon Dioxide Reactivity During Propofol-Induced EEG Suppression

Matta

Lam

Strebel

et al. 1995

Survey of Anesthesiology

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Section: Discussionsupporting

confidence: 68%

Cerebral Pressure Autoregulation and Carbon Dioxide Reactivity During Propofol-Induced EEG Suppression

Matta

Lam

Strebel

et al. 1995

Survey of Anesthesiology

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“…The possibility of studying the effects of mental activity on CBF was verified by using the 133Xe intracarotid injection technique (Ingvar and Ris berg, 1965; Risberg and lngvar, 1973;Ingvar, 1975; Since flow velocity in the cerebral arteries is di rectly related to the diameter of the small resistance vessels (while the large basal arteries remain con stant in diameter) (Huber and Handa, 1967), an in crease of regional metabolism, associated with neu ronal activity, would promote dilatation of the pre capillary bed and, therefore, lead to an increase of flow velocity in the proximal portion of the artery supplying the cortical territory involved (Raichle, 1976). the performance of cognitive tasks.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Simultaneous Assessment of Cerebral Flow Velocity during Mental Activity

Silvestrini

Cupini

Matteis

et al. 1994

J Cereb Blood Flow Metab

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Summary: The purpose of this study was to assess the potential of trans cranial Doppler (TCD) ultrasonography for detecting selective changes in cerebral blood flow ve locity during mental activity. Mean flow velocity was continuously and simultaneously measured in the right and left middle cerebral arteries in 26 healthy right handed young subjects at rest and during performance of verbal and visual-imaging mental tasks. These two mental tasks produced significantly different effects on the right and left sides: the verbal task produced a higher increase of flow velocity (mean absolute difference above baseline ± SD) with respect to the basal values in the left than in the right middle cerebral artery (5.56 ± 3.8 cm/s vs 1.25 ± 3.1 cm/s); the visual-imaging task was accompanied by aThe first observation that correlated brain activ ity and blood flow changes goes back to Fulton (1928), who reported an increase in blood flow mur mur over a patient's occipital angioma during read ing. Since then, several studies have been carried out to evaluate changes of regional cerebral blood flow (CBF) during mental activities (Risberg, 1986). Address correspondence and reprint requests to Dr. Mauro Silvestrini at Clinic a Neurologica, Universita' di Roma "Tor Vergata", Ospedale S. Eugenio, P.le dell'Umanesimo 10, 00144, Rome, Italy Abbreviations used: ANOVA, analysis of variance; EDR, electrodermal response; HR, heart rate; MBP, mean blood pres sure; MCA, middle cerebral artery; MFV, mean flow velocity; PET, positron emission tomography; TCD, trans cranial Doppler. 643higher increase in the right than in the left middle cerebral artery (3. 92 ± 3.3 cm/s vs 1.52 ± 3.1 cm/s)-analysis of variance (ANOV A) three-fold interaction side of record ing x task x condition, F = 25.67, p < . 0001 ) . Heart rate, blood pressure, and skin conductance showed compara ble increases during performance of both mental tasks. Respiratory activity showed no modification during the mental activity with respect to the rest phase. These re sults demonstrate the possibility of delivering specific functional information via bilateral TCD and suggest wider utilization of this noninvasive technique in neuro psychological studies.

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“…All physiological parameters were kept stable during the TCDI examination. Carbon dioxide (PaCO 2 ) levels were not measured as angiographic studies have demonstrated that the larger human basal cerebral arteries are unresponsive (at least within the tolerances of measurements) to changes in PaCO 2 , while arteries that had diameters less than 1 mm responded [15]. None of the TBM children were ventilated or exhibited abnormal breathing patterns during the TCDI.…”

Section: Methodsmentioning

confidence: 99%

The value of transcranial Doppler imaging in children with tuberculous meningitis

et al. 2014

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Purpose Transcranial Doppler imaging (TCDI) is potentially a valuable investigational tool in children with tuberculous meningitis (TBM), a condition often complicated by pathology relevant to Doppler imaging such as raised intracranial pressure (ICP) and cerebral vasculopathies. Methods Serial TCDI was performed on 20 TBM children with the aim of investigating cerebrovascular haemodynamics and the relationship between pulsatility index (PI) and ICP. Results We observed a poor correlation between ICP and PI in children with communicating hydrocephalus (p=0.72). No decline in PI was noted following 7 days of medical therapy for communicating hydrocephalus (p=0.78) despite a concomitant decline in ICP. Conversely, a decline in PI was noted in all four children with non-communicating hydrocephalus who underwent cerebrospinal fluid diversion. High blood flow velocities (BFV) in all the basal cerebral arteries were observed in 14 children (70 %). The high BFV persisted for 7 days suggesting stenosis due to vasculitis rather than functional vasospasm. Complete middle cerebral artery (MCA) occlusion, subnormal mean MCA velocities (<40 cm/s) and PIs (<0.4) correlated with radiologically proven large cerebral infarcts. Conclusions TCDI-derived PI is not a reliable indicator of raised ICP in children with tuberculous hydrocephalus. This may be attributed to individual variation of tuberculous vascular disease, possibly compromising cerebral vascular compliance and resistance. Basal artery stenosis secondary to vasculitis is observed during the acute stage of TBM in the majority of children.

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Effect of Contrast Material, Hypercapnia, Hyperventilation, Hypertonic Glucose and Papaverine on the Diameter of the Cerebral Arteries

Cited by 363 publications

References 0 publications

Cerebral Pressure Autoregulation and Carbon Dioxide Reactivity During Propofol-Induced EEG Suppression

Cerebral Pressure Autoregulation and Carbon Dioxide Reactivity During Propofol-Induced EEG Suppression

Bilateral Simultaneous Assessment of Cerebral Flow Velocity during Mental Activity

The value of transcranial Doppler imaging in children with tuberculous meningitis

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