Effect of continuous positive airway pressure on oxidative stress accompanied by obstructive sleep apnea

Abstract

IntroductionIn obstructive sleep apnea ( OSA), there is increased oxidative stress. Aim of this workThis study aimed to examine the effect of continuous positive airway pressure (CPAP) on oxidative stress occurring in OSA. Participants and methodsThe present study was carried out on 40 individuals classifi ed into four groups: group I included 10 control participants, group II included 10 obese individuals without OSA, group III included 10 patients with mild to moderate OSA, and group IV included 10 patients with severe OSA. Sleep study was carried out, and Thiobarbituric acid-reactive substance and superoxide dismutase enzyme were measured. ResultsThiobarbituric acid-reactive substance was signifi cantly increased, but superoxide dismutase was signifi cantly decreased in group IV, and CPAP led to an improvement in this condition. ConclusionOSA leads to increased oxidative stress that improved with the use of CPAP.

Circulating Malondialdehyde Concentrations in Obstructive Sleep Apnea (OSA): A Systematic Review and Meta-Analysis with Meta-Regression

“…Conversely, age (t = −2.06, p = 0.049), assay type (t = 2.31, p = 0.03) and publication year (t = 2.08, p = 0.048) were significantly associated with the SMD. In order to evaluate the relationship between effect size and disease severity we performed a meta-analysis in a sub-group of nine studies reporting MDA concentrations in groups with different disease severity [32,35,37,38,42,45,47,49,52]. The forest plot for MDA concentrations in mild and severe OSA patients is reported in Figure 8.…”

Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis

“…After a full-text revision of 16 articles, three studies were further excluded because of missing information. Thus, thirteen studies were included in the meta-analysis [ 14 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. A total of 847 OSA patients (mean age 47 years, 74% males) and 438 controls (mean age 50 years, 72% males) were evaluated.…”

“…Eight studies with a total of 256 OSA patients (mean age 49 years, 82% males), and 175 controls (mean age 52 years, 84% males) were evaluated [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ].…”

“…The risk of bias was considered low in seven studies [ 24 , 25 , 26 , 27 , 28 , 29 , 30 ] and moderate in the remaining one [ 23 ] ( Table 2 ).…”

“…Meta-Analysis of Blood SOD Concentrations3.2.1. Study CharacteristicsEight studies with a total of 256 OSA patients (mean age 49 years, 82% males), and 175 controls (mean age 52 years, 84% males) were evaluated[23][24][25][26][27][28][29][30].…”