“…The authors concluded that randomised clinical trials were needed to confirm their results. Since then, more than 20 studies have been published on different aspects of the effect of CPAP treatment in patients with RH or RfH: nine randomised controlled trials [RCT] [17,71,77,78,79,80,81,82,83], two of them on the effect on aldosterone concentration [79,82] and one on the effect on leptin concentration [84] (Table 2); four observational trials [84,85,86,87]; five meta-analyses and systematic reviews [72,88,89,90,91]; and, finally, five studies on additional topics, such as methodology [92], personalised medicine [75], adherence to CPAP treatment [93] and the combined effect of CPAP and renal denervation [63]. The first RCT on the effect of CPAP on BP levels in RH was performed by Lozano et al in 2010 [77] in 64 patients with ABPM-confirmed RH.…”