Effect of Continuous Positive Airway Pressure and Upper Airway Surgery on Exhaled Breath Condensate and Serum Biomarkers in Patients With Sleep Apnea

Lloberes, Patrícia; Sánchez-Vidaurre, Sara; Ferré, Àlex; Cruz, María Jesús; Lorente, Juan; Sampol, Gabriel; Morell, Ferrán; Muñoz, Xavier

doi:10.1016/j.arbr.2014.02.010

Cited by 10 publications

(12 citation statements)

References 32 publications

(47 reference statements)

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“…When EBC nitrite and nitrate were measured together, no difference was shown in OSA [71]. CPAP treatment did not change EBC nitrate levels [26,69]. However, EBC nitrotyrosine significantly decreased following CPAP [68].…”

Section: Accepted Manuscriptmentioning

confidence: 86%

“…CPAP significantly increased EBC pH in one [26], but not in the other studies [69,79]. Upper airway surgery did not change EBC pH values [69]. Overall therefore the findings are mixed but the positive studies potentially highlight the possibility that an acid environment in the airways of subjects with OSA is present.…”

Section: Ebc Aciditymentioning

confidence: 90%

“…EBC pH was inversely related to AHI and neck circumference in one [23], but not in the other study [79]. CPAP significantly increased EBC pH in one [26], but not in the other studies [69,79]. Upper airway surgery did not change EBC pH values [69].…”

Section: Ebc Aciditymentioning

confidence: 96%

“…CPAP therapy significantly reduced EBC IL-6 concentrations in some [64,68], but not all M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT [69] studies. Upper airway surgery did not appear to reduce EBC IL-6 levels, however only 9 patients were investigated [69].…”

Section: Ebc Cytokinesmentioning

confidence: 96%

“…Upper airway surgery did not appear to reduce EBC IL-6 levels, however only 9 patients were investigated [69].…”

Section: Ebc Cytokinesmentioning

confidence: 99%

See 4 more Smart Citations

Exhaled breath analysis, a simple tool to study the pathophysiology of obstructive sleep apnoea

Bikov

Hull

Kunos

2016

Sleep Medicine Reviews

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Section: Accepted Manuscriptmentioning

confidence: 86%

Section: Ebc Aciditymentioning

confidence: 90%

Section: Ebc Aciditymentioning

confidence: 96%

Section: Ebc Cytokinesmentioning

confidence: 96%

“…Upper airway surgery did not appear to reduce EBC IL-6 levels, however only 9 patients were investigated [69].…”

Section: Ebc Cytokinesmentioning

confidence: 99%

See 3 more Smart Citations

Exhaled breath analysis, a simple tool to study the pathophysiology of obstructive sleep apnoea

Bikov

Hull

Kunos

2016

Sleep Medicine Reviews

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Expression of Leukotriene Biosynthetic Enzymes in Tonsillar Tissue of Children With Obstructive Sleep Apnea

Tsaoussoglou

Hatzinikolaou

Baltatzis

et al. 2014

JAMA Otolaryngol Head Neck Surg

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Effect of Sleep Surgery on Inflammatory Cytokines in Adult Obstructive Sleep Apnea: A Systematic Review and Meta‐Analysis

et al. 2022

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Objective To evaluate whether sleep surgery is associated with inflammatory cytokine changes. This study hypothesizes cytokines may change after surgery in adult obstructive sleep apnea (OSA). Study Design Systematic review and meta‐analysis. Methods The study protocol was registered on PROSPERO (CRD42020154425). Two authors independently searched PubMed, Embase, and Cochrane review databases from their inception to June 2021. The keywords used were sleep apnea, inflammatory markers, cytokines, and surgery. The effects of sleep surgery on the apnea–hypopnea index (AHI) and inflammatory cytokines were evaluated using a random‐effects model. Both mean difference (MD) and standardized mean difference (SMD) of the changes in cytokines were calculated. Results Nine studies with 235 adults were included (mean age: 43 years; 82% were men). After sleep surgery, AHI significantly reduced by −11.3 events/h (95% confidence interval [CI], −15.8 to −6.9). In total, 8 and 6 studies were pooled for examining tumor necrosis factor‐alpha (TNF‐α) and interleukin‐6 (IL‐6) levels, respectively. Sleep surgery significantly reduced TNF‐α levels, with an MD of −2.8 pg/ml (95% CI, −5.1 to −0.6) and an SMD of −0.56 (95% CI, −0.85 to −0.27). Furthermore, sleep surgery reduced IL‐6 levels, with an MD of −0.6 pg/ml (95% CI, −1.0 to −0.2) and an SMD of −0.66 (95% CI, −0.89 to −0.43). No covariates were identified to be correlated with cytokine changes in subgroup and meta‐regression analyses. Funnel plots showed possible publication bias in current data. Conclusions In adults, OSA treatment with sleep surgery improves inflammatory cytokines. Laryngoscope, 132:2275–2284, 2022

show abstract

Effect of Continuous Positive Airway Pressure and Upper Airway Surgery on Exhaled Breath Condensate and Serum Biomarkers in Patients With Sleep Apnea

Cited by 10 publications

References 32 publications

Exhaled breath analysis, a simple tool to study the pathophysiology of obstructive sleep apnoea

Exhaled breath analysis, a simple tool to study the pathophysiology of obstructive sleep apnoea

Expression of Leukotriene Biosynthetic Enzymes in Tonsillar Tissue of Children With Obstructive Sleep Apnea

Effect of Sleep Surgery on Inflammatory Cytokines in Adult Obstructive Sleep Apnea: A Systematic Review and Meta‐Analysis

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