Effect of continuous oestradiol-medroxyprogesterone administration on plasma lipids and lipoproteins

Cano, Antonio; Fernandes, Helena; Serrano, S; Mahiques, P.

doi:10.1016/0378-5122(91)90283-v

Cited by 22 publications

(1 citation statement)

References 22 publications

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“…Previous research on estrogen combined with a synthetic progestin has been inconsistent, with some studies showing favorable results on lipids (207–212), although sometimes less favorable than with estrogen alone (213,214). One population‐based cross‐sectional study, however, comparing ERT users with HRT users among 4,958 women actually found more favorable levels with HRT, as estrogen alone elevated triglyceride, factor VII, and protein C levels (215).…”

Section: Hormones As Prevention For Conditions Associated With Agingmentioning

confidence: 99%

Perimenopausal and postmenopausal hormone replacement therapy Part 1. An update of the literature on benefits and risks*1

Lichtman¹

1996

Journal of Nurse-Midwifery

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Section: Hormones As Prevention For Conditions Associated With Agingmentioning

confidence: 99%

Perimenopausal and postmenopausal hormone replacement therapy Part 1. An update of the literature on benefits and risks*1

Lichtman¹

1996

Journal of Nurse-Midwifery

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Postmenopausal hormone replacement

1993

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Effects of combined female sex hormone replacement therapy on body fat percentage and distribution

et al. 2006

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The effectiveness of hormone replacement therapy for patients with cardiovascular disease and for postmenopausal women with associated cardiovascular risks is currently under wide investigation. Among the cardiovascular risks are those related to body fat percentage and distribution. The present study undertook to investigate the effects of combined hormone replacement therapy on body fat percentage and distribution in postmenopausal women. Data for the present study were collected via retrospective analyses of 287 healthy postmenopausal women (146 as a study group, 141 as controls). Participants in the study group received 0.625 mg conjugated equine estrogen combined with 2.5 mg medroxyprogesterone acetate per day for 18 months. Body fat percentage and fat distribution were evaluated through the electrical impedance method and measurements of skinfold thickness, respectively. Two indices of centripetal fat distribution were defined: ratio of trunk-to-extremity skinfold thickness (T/E index), and ratio of upper-to-lower body skinfold thickness (U/L index). Investigators found that a daily dose of 0.625 mg of conjugated equine estrogen combined with 2.5 mg of medroxyprogesterone acetate taken for 18 months increased body fat percentage by decreasing lean body mass and by affecting upper-to-lower body fat distribution, without producing significant changes in overall weight. A slight decrease in the trunk-to-extremity body fat ratio was noted at 18 months of treatment, but this decrease did not reach statistical significance. Data related to the effects of hormone replacement therapy on body fat percentage and distribution in postmenopausal women are scarce. Additional research is needed to clarify the possible health benefits of hormone replacement therapy.

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Effect of continuous oestradiol-medroxyprogesterone administration on plasma lipids and lipoproteins

Cited by 22 publications

References 22 publications

Perimenopausal and postmenopausal hormone replacement therapy Part 1. An update of the literature on benefits and risks*1

Perimenopausal and postmenopausal hormone replacement therapy Part 1. An update of the literature on benefits and risks*1

Postmenopausal hormone replacement

Effects of combined female sex hormone replacement therapy on body fat percentage and distribution

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