Effect of Contact Lens Disinfectants Against Acanthamoeba Cysts

Acanthamoeba keratitis: A masquerade of presentation in six cases

“…It is therefore essential that ophthalmologists and optometrists reinforce the appropriate method of disinfection, the avoidance of tap water or other possibly contaminated water and the need for prolonged disinfection, preferably overnight, if soaking solutions are used. 28 It is very disturbing to note that several manufacturers suggest the use of tap water at some point in the lens care process despite its well known association with Acanrhamoeba keratitis. Strict adherence to simple public health guidelines regarding contact lens cleaning has resulted in a significant decline in the incidence of Acanthamoeba keratitis in the United States (Personal communication, D Jones, Houston).…”

Efficacy of commercial soft contact lens disinfectant solutions against Acanthamoeba

“…Although numerous studies have been performed to evaluate the effects of different SCL disinfectant solutions on Acanthamoeba [10][11][12][13][14][15][16][17], differences in methodology have made it difficult to compare the results of these studies and reach conclusions regarding the relative efficacy of the products. This situation is partially because there is no standardized method for evaluating the efficacy of lens care products against Acanthamoeba.…”

Acanthamoeba: A Review of Its Potential to Cause Keratitis, Current Lens Care Solution Disinfection Standards and Methodologies, and Strategies to Reduce Patient Risk

“…In fact, 1 trial presented a 1 log increase in cyst numbers over the control and cysts cannot replicate. These inves- 68 Consequently, the testing methods and data disparity in the SCL product Acanthamoeba disinfection efficacy literature continues to this date. However, the root cause of AK remains constant as stated in the MowreyMcKee/George paper: "Exposure to Acanthamoeba in contaminated water has been the chief implicating keratitis factor leading to the recent recommendations that tap water not be used in the care of orthokeratology lenses and cases," and the same should be for all SCL wearers.…”