Effect of conjugates of all-trans-retinoic acid and shorter polyene chain analogues with amino acids on prostate cancer cell growth

Sadikoglou, Eldem; Magoulas, George E.; Theodoropoulou, Christina; Athanassopoulos, Constantinos M.; Giannopoulou, Efstathia; Theodorakopoulou, Olga; Drainas, Denis; Papaioannou, D.; Papadimitriou, Evangelia

doi:10.1016/j.ejmech.2009.03.029

Cited by 12 publications

(4 citation statements)

References 24 publications

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“…Ro415253 inhibited the effects of ATRA, but the decrease in the number of LNCaP cells caused by conjugates with leucine and β-alanine was not totally counterbalanced. It was suggested that the mechanisms of action of these conjugates were not the same as for ATRA [85].…”

Section: All-trans-retinoic Acid Retinol and Vitamin Amentioning

confidence: 99%

Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action

et al. 2021

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Among the vast variety of plant-derived phytochemicals, the group of carotenoids has continuously been investigated in order to optimize their potential application in the area of dietary intervention and medicine. One organ which has been especially targeted in many of these studies and clinical trials is the human prostate. Without doubt, carotenoids (and their endogenous derivatives—retinoids and other apo-carotenoids) are involved in intra- and intercellular signaling, cell growth and differentiation of prostate tissue. Due to the accumulation of new data on the role of different carotenoids such as lycopene (LC) and β-carotene (BC) in prostatic physiology and pathology, the present review aims to cover the past ten years of research in this area. Data from experimental studies are presented in the first part of the review, while epidemiological studies are disclosed and discussed in the second part. The objective of this compilation is to emphasize the present state of knowledge regarding the most potent molecular targets of carotenoids and their main metabolites, as well as to propose promising carotenoid agents for the prevention and treatment of prostatic diseases.

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Section: All-trans-retinoic Acid Retinol and Vitamin Amentioning

confidence: 99%

Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action

et al. 2021

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“…Опухоль-супрессорная активность РК показана для многих типов опухолей. Эта кислота не только стимулирует дифференцировку [21][22][23][24], но и снижает пролиферативную активность опухолевых клеток [25,26], активирует процесс апоптоза [27][28][29], а также подавляет ангиогенез [30,31]. В клинической практике ATRA наиболее успешно используется в качестве основного препарата при терапии острого промиелоцитарного лейкоза [13,[32][33][34][35][36].…”

Section: Introductionunclassified

Resistance of breast cancer cells to all-trans retinoic acid is associated with a decrease in the basal level of nuclear receptor RARα expression and induction of cytochrome CYP26A1 and CYP26B1 expression

et al. 2022

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Introduction. Retinoic acid (RA) is a key regulator of cell differentiation and a critical player in such systemic processes in the body as embryonic development, immune system cell maturation and functioning, tissue remodeling and several others. This compound displays an antitumor activity due to its ability to stimulate differentiation, induce apoptosis and inhibit proliferation of malignant cells. The rapid acquisition of resistance to RA and its analogues by solid tumor cells is one of the main problems limiting the widespread use of retinoids in the therapy of malignant neoplasms. The mechanisms of RA-resistance are still poorly understood.The study objective – assessment of the relationship between the basal expression level of the nuclear RARα receptor and the RA-induced expression of the cytochromes CYP26A1and CYP26B1 with the resistance of breast cancer cells to the action of all-trans-retinoic acid.Materials and methods. Cell lines were cultured, the sensitivity of breast cancer cells to the action of fully trans-retinoic acid, RNA isolation, reverse transcription reaction and real-time polymerase chain reaction were analyzed).Results. In present study, using an experimental model represented by 9 breast cancer cell lines with different level of sensitivity to RA, we showed that the expression of the RA nuclear receptor RARα, as well as the level of mRNA induction of CYP26A1 and CYP26B1 cytochromes in response to RA treatment correlate with RA-sensitivity.Conclusion. Thus, a decrease of RARα expression as well as the reduced ability to catabolize RA are factors associated with RA-resistance of breast cancer cells.

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“…Исследования доказывают способность РК подавлять пролиферацию опухолевых клеток [16,17,24], а также ингибировать ангиогенез [25,26]. Способность стимулировать апоп-тоз также продемонстрирована на целом ряде опухо-левых клеток различного происхождения [27][28][29]. Показано, что РК активирует экспрессию некоторых проапоптотических генов, в частности каспаз-7 и -9 [30], однако механизм РК-зависимой активации про-граммированной клеточной гибели до конца не ясен.…”

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CRABP proteins – relatives or homonyms?

Чевкина¹,

Фаворская²

2015

Usp. mol. onkol

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ОБЗОРНЫЕ СТАТЬИ ТОМ 2 6Введение Белки CRABP (cellular retinoic acid binding proteins) относятся к семейству iLBPs (intracellular lipid binding proteins), представленному небольшими белками, обладающими очень сходной структурой, но селектив-но связывающими лиганды (различные липофильные молекулы) [1][2][3]. В частности, белки CRABP1 и CRABP2 связывают ретиноевую кислоту (РК),

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Effect of conjugates of all-trans-retinoic acid and shorter polyene chain analogues with amino acids on prostate cancer cell growth

Cited by 12 publications

References 24 publications

Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action

Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action

Resistance of breast cancer cells to all-trans retinoic acid is associated with a decrease in the basal level of nuclear receptor <i>RARα</i> expression and induction of cytochrome <i>CYP26A1</i> and <i>CYP26B1</i> expression

CRABP proteins – relatives or homonyms?

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