Effect of conjugated linoleic acid on blood inflammatory markers: a systematic review and meta-analysis on randomized controlled trials

Haghighatdoost, Fahimeh; Gh, B. Fatemeh Nobakht M.

doi:10.1038/s41430-017-0048-z

Cited by 18 publications

(14 citation statements)

References 74 publications

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“…While several studies in rodents and cell culture showed CLA is an anti-inflammatory molecule, some authors do not consider that its anti-inflammatory effects have been sufficiently demonstrated in humans [55]. In addition, other studies have clearly marked CLA as a proinflammatory inductor [56,57], indicating that this effect could be greatly heterogeneous depending on physiological conditions, animal species and the dose of CLA. In addition, initial studies in cells showed that CLA, specifically t10,c12, presented ameliorating effects over the production of reactive oxygen species (ROS), correlating to lower gene expression of inflammatory markers [58].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, initial studies in cells showed that CLA, specifically t10,c12, presented ameliorating effects over the production of reactive oxygen species (ROS), correlating to lower gene expression of inflammatory markers [58]. Some studies in humans revealed consistent improvements in inflammation with a reduction in TNF-α (tumour necrosis factor α) and IL-1β (interleukin 1-β) levels [59], while others found increases in TNF-α values [56]. Thus, although there is no clear consensus of the effect of CLA on inflammation, our results indicated that low doses of CLA have the ability to decrease the gene expression of Ccl2 in the liver as well as the levels of diglycerides, which have been reported as key markers of hepatic inflammation [60,61].…”

Section: Discussionmentioning

confidence: 99%

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Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats

et al. 2020

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Conjugated linoleic acid (CLA) is a dietary supplement that has been shown to improve obesity. However, some authors have associated high doses of CLA supplementation with liver impairment and insulin resistance. The aim of this study was to assess whether the consumption of low doses of CLA maintained the beneficial effects on the main metabolic disturbances associated with metabolic syndrome (MetS) but prevented the occurrence of non-desirable outcomes associated with its consumption. Male Wistar rats, fed standard or cafeteria (CAF) diet for 12 weeks, were supplemented with three different low doses of CLA in the last three weeks. Both biochemical and H1 NMR-based metabolomics profiles were analysed in serum and liver. The consumption of 100 mg/kg CLA, but not doses of 200 and 300 mg/kg, ameliorated the increase in body weight gain as well as the serum concentrations of glucose, insulin, cholesterol, triglyceride, diglyceride, and total phospholipid induced by a CAF diet. In turn, CLA reverted the increase in lactate, alanine, and glucose concentrations in the liver of these animals, but enhanced hepatic cholesterol accumulation without any detrimental effect on liver function. In conclusion, a low dose of CLA corrected the adverse effects associated with MetS without compromising other metabolic parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats

et al. 2020

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“…However, no beneficial effects of resveratrol intake on lowering the inflammatory marker C-reactive protein (CRP) were found, neither in a meta-analysis of randomized controlled trial [135] nor in a later accomplished randomized placebo-controlled clinical trial [136]. These data are, however, in contrast with two more recent meta-analyses concluding the CRP-lowering effects of resveratrol use [137,138].…”

Section: Clinical Studies On Resveratrol In the Context Of Cardiovmentioning

confidence: 99%

Resveratrol and Its Effects on the Vascular System

Breuss

Atanasov

Uhrín

2019

IJMS

206

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Resveratrol, the phenolic substance isolated initially from Veratrum grandiflorum and richly present in grapes, wine, peanuts, soy, and berries, has been attracting attention of scientists and medical doctors for many decades. Herein, we review its effects on the vascular system. Studies utilizing cell cultures and pre-clinical models showed that resveratrol alleviates oxidative stress and inflammation. Furthermore, resveratrol suppresses vascular smooth muscle cell proliferation, promotes autophagy, and has been investigated in the context of vascular senescence. Pre-clinical models unambiguously demonstrated numerous vasculoprotective effects of resveratrol. In clinical trials, resveratrol moderately diminished systolic blood pressure in hypertensive patients, as well as blood glucose in patients with diabetes mellitus. Yet, open questions remain, as exemplified by a recent report which states that the intake of resveratrol might blunt certain positive effects of exercise in older persons, and further research addressing the framework for long-term use of resveratrol as a food supplement, will stay in demand.

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“…However, the authors observed that participants with lower ω-6 FA intake at baseline seemed to have greater protection, and an increased intake of ω-6 FA may reduce the risk of myocardial infarction (MI) (RR 0.88, 95%CI 0.76 to 1.02). In addition, a meta-analysis (130) of 11 RCTs including 420 subjects showed that conjugated linoleic acid (CLA) supplementation increased blood levels of CRP by 0.89 mg/L (95% CI: 0.11, 1.68; P = 0.025) and TNF-α levels by 0.39 pg/mL (95% CI: 0.23, 0.55; P < 0.0001). Nonetheless, another meta-analysis (131) concluded that CLA supplements had a proinflammatory effect after observing an increase in plasma CRP concentrations and significant reductions in serum adiponectin concentrations independently of the dosage of CLA supplementation (0.63 mg/dL, 95% CI: 0.13, 1.13, heterogeneity P = 0.026; I 2 = 52.3%).…”

Section: Omega-6mentioning

confidence: 99%

Clinical Advances in Immunonutrition and Atherosclerosis: A Review

et al. 2019

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Atherosclerosis is a chronic low-grade inflammatory disease that affects large and medium-sized arteries and is considered to be a major underlying cause of cardiovascular disease (CVD). The high risk of mortality by atherosclerosis has led to the development of new strategies for disease prevention and management, including immunonutrition. Plant-based dietary patterns, functional foods, dietary supplements, and bioactive compounds such as the Mediterranean Diet, berries, polyunsaturated fatty acids, ω-3 and ω-6, vitamins E, A, C, and D, coenzyme Q10, as well as phytochemicals including isoflavones, stilbenes, and sterols have been associated with improvement in atheroma plaque at an inflammatory level. However, many of these correlations have been obtained in vitro and in experimental animals' models. On one hand, the present review focuses on the evidence obtained from epidemiological, dietary intervention and supplementation studies in humans supporting the role of immunonutrient supplementation and its effect on anti-inflammatory response in atherosclerotic disease. On the other hand, this review also analyzes the possible molecular mechanisms underlying the protective action of these supplements, which may lead a novel therapeutic approach to prevent or attenuate diet-related disease, such as atherosclerosis.

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Effect of conjugated linoleic acid on blood inflammatory markers: a systematic review and meta-analysis on randomized controlled trials

Abstract: This meta-analysis showed that CLA supplementation may increase inflammatory markers (CRP and TNF-α). There are concerns about using CLA supplementation as an anti-obesity agent among the obese population for at least a short duration.

Cited by 18 publications

References 74 publications

Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats

Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats

Resveratrol and Its Effects on the Vascular System

Clinical Advances in Immunonutrition and Atherosclerosis: A Review

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