Effect of Conjugated Bile Salt Taurodeoxycholic Acid (TDCA) on Mice Colonic Motor Activity

Abdu, Faiza; Albaik, Mai

doi:10.18054/pb.2016.118.2.3673

Cited by 4 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with PD exhibit increased microglial activity [ 131 ], BBB permeability [ 58 ], α-synuclein aggregation [ 128 ], MAO-B expression [ 97 ], LPS secretion [ 131 ], intestinal permeability, intestinal layer mucin degradation, and pro-inflammatory cytokine release [ 131 ]. There is a decrease in BDNF expression and tyrosine hydroxylase expression [ 34 ], butyrate synthesis, and TDCA concentration [ 132 ]. Abbreviations: BDNF, brain-derived neurotrophic factor; BBB, blood–brain barrier; MAO-B, monoamine oxidase B; LPS, lipopolysaccharide; IL-1, interleukin-1; TNFα, tumor necrosis factor α; TDCA, taurochenodeoxycholic acid.…”

Section: Microbiota Dopamine and Parkinson’s Diseasementioning

confidence: 99%

“…Since SCFAs increase α-synuclein deposition in enteric neurons [ 122 ], increased abundance of SCFA-producing microbial species attenuates constipation symptoms over time by reducing α-synuclein aggregation. Additionally, Lactobacillus deconjugates bile acids such as TDCA in the GI tract, which has been shown to inhibit intestinal motility [ 132 ] in addition to its neuroprotective effects. Thus, it is possible that the introduction of Lactobacillus can restore GI motility by deconjugating TDCA and removing its inhibitory effect.…”

Section: Microbiota Dopamine and Parkinson’s Diseasementioning

confidence: 99%

See 1 more Smart Citation

Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling

et al. 2022

View full text Add to dashboard Cite

Dopamine is a neurotransmitter that plays a critical role both peripherally and centrally in vital functions such as cognition, reward, satiety, voluntary motor movements, pleasure, and motivation. Optimal dopamine bioavailability is essential for normal brain functioning and protection against the development of neurological diseases. Emerging evidence shows that gut microbiota have significant roles in maintaining adequate concentrations of dopamine via intricate, bidirectional communication known as the microbiota-gut-brain axis. The vagus nerve, immune system, hypothalamus–pituitary–adrenal axis, and microbial metabolites serve as important mediators of the reciprocal microbiota-gut-brain signaling. Furthermore, gut microbiota contain intrinsic enzymatic activity that is highly involved in dopamine metabolism, facilitating dopamine synthesis as well as its metabolite breakdown. This review examines the relationship between key genera of gut microbiota such as Prevotella, Bacteroides, Lactobacillus, Bifidobacterium, Clostridium, Enterococcus, and Ruminococcus and their effects on dopamine. The effects of gut dysbiosis on dopamine bioavailability and the subsequent impact on dopamine-related pathological conditions such as Parkinson’s disease are also discussed. Understanding the role of gut microbiota in modulating dopamine activity and bioavailability both in the periphery and in the central nervous system can help identify new therapeutic targets as well as optimize available methods to prevent, delay, or restore dopaminergic deficits in neurologic and metabolic disorders.

show abstract

Section: Microbiota Dopamine and Parkinson’s Diseasementioning

confidence: 99%

Section: Microbiota Dopamine and Parkinson’s Diseasementioning

confidence: 99%

Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Furthermore, the concentration of T‐UDCA, a BA which has been neuroprotective in Alzheimer's, Parkinson's, and Huntington's diseases, increased slightly when TUR was consumed prior to the MF breakfast (Table ). In contrast, the T‐DCA concentration decreased markedly with TUR consumption prior to the HF breakfast challenge; which could be of interest, as a study by Abdu et al., showed that T‐DCA was able to inhibit colon motility in mice and thus increase the risk of constipation. The increase of T‐LCA after TUR ingestion prior to the HF breakfast, is more difficult to explain and also its impact on health effects.…”

Section: Discussionmentioning

confidence: 97%

Postprandial Responses of Serum Bile Acids in Healthy Humans after Ingestion of Turmeric before Medium/High‐Fat Breakfasts

Ghaffarzadegan

Zanzer

Hållenius

et al. 2019

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope: Bile acids (BAs) are known to regulate a number of metabolic activities in the body. However, very little is known about how BAs are affected by diet. This study aims to investigate whether a single dose of turmeric-based beverage (TUR) before ingestion of medium-(MF) or high-fat (HF) breakfasts would improve the BA profile in healthy subjects. Methods and results: Twelve healthy subjects are assigned to a randomized crossover single-blind study. The subjects receive isocaloric MF or HF breakfasts after a drink containing flavored water with or without an extract of turmeric with at least 1-week wash-out period between the treatments. Postprandial BAs are measured using protein precipitation followed by ultra-high-performance liquid chromatography−mass spectrometry analysis. The concentration of BAs is generally higher after HF than MF breakfasts. Ingestion of TUR before MF breakfast increases the serum concentrations of free and conjugated forms of cholic (CA) and ursodeoxycholic acids (UDCA), as well as the concentrations of chenodeoxycholic acid (CDCA) and its taurine-conjugated forms. However, the concentration of conjugated forms of deoxycholic acid (DCA) decreases when TUR is taken before HF breakfast.

show abstract