Effect of concurrent elemental diet on infliximab treatment for Crohn’s disease

Tanaka, Tamami; Takahama, Kazuya; Kimura, Tomomi; Mizuno, Tamaki; Nagasaka, Mitsuo; Iwata, Katsumi; Nakano, Hiroshi; Muramatsu, Masaaki; Takazoe, Masakazu

doi:10.1111/j.1440-1746.2006.04317.x

Cited by 37 publications

(38 citation statements)

References 27 publications

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“…Elemental diet therapy (ED) is high-calorie liquid diets containing primarily amino acids that are absorbed by the small intestine without digestion, and was originally developed as food for astronauts who worked for the National Aeronautics and Space Administration in the 1960s [47].…”

Section: Impact Of Diet On Treatment Results From Anti-tnf Treatmentmentioning

confidence: 99%

“…In a retrospective study of primary response in 110 CD patients that received either one single infusion (luminal disease) or three infusions (fistulising disease) with the anti-TNFα drug Infliximab (IFX), 51 patients concomitantly received ED [47]. CD activity index (CDAI) was assessed and CDAI < 150 was defined as clinical remission.…”

Section: Impact Of Diet On Treatment Results From Anti-tnf Treatmentmentioning

confidence: 99%

“…A recent meta-analysis by Nguyen et al on the use of IFX monotherapy versus specialised enteral nutrition therapy combination with IFX reviewed 1 prospective study (56 patients) and 3 retrospective studies (in total 295 patients, including the study by Tanaka [47], but not the later study by Kamata [49]) [44]. The daily amount of enteral nutrition ranged from 600 kcal to 1500 kcal/day.…”

Section: Impact Of Diet On Treatment Results From Anti-tnf Treatmentmentioning

confidence: 99%

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Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

Andersen¹,

Hansen²,

Heitmann³

2017

Preprint

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Abstract:We wanted to investigate the current knowledge on the impact of diet on anti-TNF response in inflammatory bowel diseases (IBD), to identify dietary factors that warrant further investigations in relation to anti-TNF treatment response, and, finally, to discuss potential strategies for such investigations. PubMed was searched using specified search terms. One small prospective study on diet and anti-TNF treatment in 56 patients with CD found similar remission rates after 56 weeks among 32 patients with good compliance that received concomitant enteral nutrition and 24 with poor compliance that had no dietary restrictions (78% versus 67%, p = 0.51). A meta-analysis of 295 patients found higher odds of achieving clinical remission and remaining in clinical remission among patients on combination therapy with specialised enteral nutrition and Infliximab (IFX) compared with IFX monotherapy (OR 2.73; 95% CI: 1.73-4.31, p < 0.01, OR 2.93; 95% CI: 1.66-5.17, p < 0.01, respectively). In conclusion, evidence-based knowledge on impact of diet on anti-TNF treatment response for clinical use is scarce. Here we propose a mechanism by which Western style diet high in meat and low in fibre may promote colonic inflammation and potentially impact treatment response to anti-TNF drugs. Further studies using hypothesis-driven and data-driven strategies in observational, animal and interventional studies are warranted.

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Section: Impact Of Diet On Treatment Results From Anti-tnf Treatmentmentioning

confidence: 99%

Section: Impact Of Diet On Treatment Results From Anti-tnf Treatmentmentioning

confidence: 99%

Section: Impact Of Diet On Treatment Results From Anti-tnf Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

Andersen¹,

Hansen²,

Heitmann³

2017

Preprint

View full text Add to dashboard Cite

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“…EN is used as both an induction and maintenance treatment (Takagi et al 2006). There are some reports that showed the efficacy of combination therapy of IFX and nutritional therapy (Matsumoto et al 2005;Tanaka et al 2006). Matsumoto et al showed that IFX was effective under TPN or EN (Matsumoto et al 2005).…”

mentioning

confidence: 99%

“…Matsumoto et al showed that IFX was effective under TPN or EN (Matsumoto et al 2005). Tanaka et al showed that CD patients with concurrent ED had a significantly higher response rate to IFX than those without EN (Tanaka et al 2006). However, there are no reports that have compared the effects on mid-and longterm prognosis among the induction and maintenance thera-pies used in Japan, especially between infliximab and EN.…”

mentioning

confidence: 99%

Scheduled Maintenance Therapy with Infliximab Improves the Prognosis of Crohn's Disease: A Single Center Prospective Cohort Study in Japan

Takahashi

Takagi

Shiga

et al. 2010

Tohoku J. Exp. Med.

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Revolution in diet therapy for inflammatory bowel disease

Melton,

Day,

Bryant

et al. 2024

JGH Open

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Until recently, diet as a therapeutic tool to treat inflammatory bowel disease (IBD) has not been proven effective. Nearly a century in the making we are in the grips of a revolution in diet therapies for IBD, driven by emerging data revealing diet as a key environmental factor associated with IBD susceptibility, and observational studies suggesting that dietary intake may play a role in the disease course of established IBD. This review summarizes the current evidence for diets trialed as induction and maintenance therapy for IBD. For Crohn's disease, exclusive enteral nutrition and the Crohn's disease exclusion diet with partial enteral nutrition are supported by emerging high‐quality evidence as induction therapy, but are short‐term approaches that are not feasible for prolonged use. Data on diet as maintenance therapy for Crohn's disease are conflicting, with some studies supporting fortification, and others suppression, of certain food components. For ulcerative colitis, data are not as robust for diet as induction and maintenance therapy; however, consistent themes are emerging, suggesting benefits for diets that are plant‐based, high in fiber and low in animal protein. Further studies for both Crohn's disease and ulcerative colitis are eagerly awaited, which will allow specific recommendations to be made. Until this time, recommendations default to population based healthy eating guidelines.

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Effect of concurrent elemental diet on infliximab treatment for Crohn’s disease

Abstract: Infliximab was clinically useful in the treatment of Crohn's disease in Japanese patients as well as in those in Western countries. The efficacy of concurrent ED was suggestive and should be confirmed in a randomized controlled study.

Cited by 37 publications

References 27 publications

Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

Scheduled Maintenance Therapy with Infliximab Improves the Prognosis of Crohn's Disease: A Single Center Prospective Cohort Study in Japan

Revolution in diet therapy for inflammatory bowel disease

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