Effect of Concomitant Consumption of Fish Oil and Vitamin E on T Cell Mediated Function in the Elderly: A Randomized Double-Blind Trial

Abstract

The immuno-enhancing effect of vitamin E in the elderly is dampened when it is concomitantly consumed with fish oil. This may be due to the smaller increase in plasma concentrations of vitamin E in the presence of fish oil.

Effect of vitamin e supplementation with exercise on cognitive functions and total antioxidant capacity in older people

“…Baseline plasma concentrations of alpha tocopherol in our study were too high compared with the findings of previous studies in elderly populations (35). This could be explained by the regional differences of dietary habbits in our subjects.…”

Dietary Intake and Supplement Use of Vitamins C and E and Upper Respiratory Tract Infection

“…It is possible that participants in our study were not old enough, or did not smoke enough for any effect measure modification to be evident. Another trial, among the elderly, found that the plasma concentrations of vitamin E may be decreased by a concomitant intake of fish oil supplements [32]. In our study, few participants took both fish oil supplements and vitamin E supplements regularly, and we did not find any large effect measure modification on dietary or supplementary vitamin E intake by fatty fish intake.…”

Cytokinesis-block micronucleus cytome assay

“…Furthermore, determining nuclear division index (NDI) and proportion of cells undergoing necrosis and apoptosis provides important information on cytostatic and cytotoxic properties of the agent being examined that is relevant to the toxicity assessment. In human lymphocytes, the NDI also provides a measure of mitogen response, which is a useful biomarker of immune response in nutrition studies and may also be related to genotoxic exposure 3,23,[36][37][38]56 . The cytome approach in the CBMN Cyt assay is important because it allows genotoxic (MNi, NPBs and NBUDs in BN cells), cytotoxic (proportion of necrotic and apoptotic cells) and cytostatic (proportion and ratios of mono-, bi-and multinucleated cells, NDI) events to be captured within one assay.…”