Effect of concentration on the plasmonic absorption and optical nonlinearity of gold nanoparticles

Rashidian, Morvarid

doi:10.1117/1.oe.51.8.089001

Cited by 16 publications

(6 citation statements)

References 24 publications

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“…PBS, phosphate buffer saline; PEG-GNR, PEGylated gold nanorod; TEM, transmission electron microscopy nonlinear change at 990 nm from 15 to 20 and 25 µg/ml could result from the nonlinear thermo-optical properties of GNR as the presence of NP can enhance both local and nonlocal nonlinear responses of the colloid. 16 To determine the proper conditions for in vivo PTT, 1064 nm laser light was irradiated on the aqueous PEG-GNR solution (concentration = 25 µg/ml in PBS) under various irradiation conditions (Figure 2). Regardless of constant power density, the temperature elevation increased with irradiation time (Figure 2A).…”

Section: Resultsmentioning

confidence: 99%

“…Thus, the concentration of 25 µg/ml was selected for the rest of testing because of the temperature increase of 15.7°C. It is noted that a nonlinear change at 990 nm from 15 to 20 and 25 µg/ml could result from the nonlinear thermo‐optical properties of GNR as the presence of NP can enhance both local and nonlocal nonlinear responses of the colloid 16 …”

Section: Resultsmentioning

confidence: 99%

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Enhancement of gold nanorods‐assisted photothermal treatment on cancer with laser power in stepwise modulation

Kim

Kang

2022

Lasers Surg Med

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Objectives: Photothermal therapy (PTT) is a minimally invasive or noninvasive method by destructing cancer cells through selective thermal decomposition. However, a long period of laser irradiation to achieve coagulative necrosis often causes unfavorable thermal damage to the surrounding healthy tissue. The current study aims to evaluate the feasibility of temporal power modulation to improve the treatment efficacy of gold nanorods-assisted PTT against tumor tissue. Materials and Methods: A total of 25 µg/ml of PEGylated gold nanorods (PEG-GNR) was used as an absorbing agent during 1064 nm laser irradiation for PTT. Temperature monitoring was conducted on the aqueous solution of PEG-GNR for dosimetry comparison. For in vivo tests, CT-26 tumor-bearing murine models with PEG-GNR injected were treated with three irradiation conditions: 3 W/cm 2 for 90 s, 1.5 W/cm 2 for 180 s, and 3 W/cm 2 for 60 s followed by 1.5 W/cm 2 for 60 s (modulated). Ten days after the treatments, histology analysis was performed to assess the extent of coagulation necrosis in the treated tissues. Results: The temporal power modulation maintained the tissue temperature of around 50°C for a longer period during the irradiation. Histology analysis confirmed that the modulated group entailed a larger coagulative necrosis area with less thermal damage to the peripheral tissue, compared to the other irradiation conditions. Conclusion: Therefore, the power-modulated PTT could improve treatment efficacy with reduced injury by maintaining the constant tissue temperature. Further studies will examine the feasibility of the proposed technique in large animal models in terms of acute and chronic tissue responses and treatment margin for clinical translations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Enhancement of gold nanorods‐assisted photothermal treatment on cancer with laser power in stepwise modulation

Kim

Kang

2022

Lasers Surg Med

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“…The absorption peak is occurred at about 516 -526 nm for all samples due to Au NPs Surface Plasmon Resonances (SPR). For SPR phenomenon to happen, the particle must be much smaller than the wavelength of incident light [9]. If the size of NPs increases, their SPR absorption peak will be shifted toward larger wavelength and vise-versa.…”

Section: Resultsmentioning

confidence: 99%

“…The size dependent properties of gold NPs make them suitable for many applications in various areas such as catalytic, optical and antibacterial applications [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Dependence of Laser Ablation Produced Gold Nanoparticles Characteristics on the Fluence of Laser Pulse

Mirghassemzadeh¹,

Ghamkhari²,

Dorranian³

2013

SNL

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Effect of laser fluence on the characteristics of gold nanoparticles (NPs) produced by laser ablation method is investigated experimentally. Five samples of gold NPs were synthesized by nanosecond pulsed laser ablation of a high purity gold plate in distilled water at five different fluences in the range of 1 -3 J/cm 2 . Results show that in this experimental condition gold NPs are produced by nucleation of Au atoms in the plasma, generated on the target surface during the ablation process. There is threshold fluence at which absorption of laser energy by water rises significantly. Absorption of the laser energy by water leads to increase oxygen atoms in the ablation medium and formation of gold oxide NPs. By increasing the laser fluence below the threshold, size of produced NPs decreases while by increasing the laser fluence above the threshold size of produced NPs increases.

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“…Metal nanoparticles (NPs) have been widely used in various fields such as biology, 1 catalysis, 2 plasmonics, 3 and metamaterials. 4 Since many applications of metal NPs rely sensitively on the concentrations of NP colloids, such as proliferation of cells, 5 bacterial growth, 6 X-ray attenuation, 7 and tuning of optical absorption and non-linearity of NPs, 8 the accurate determination of the NP concentration in a colloidal solution is of high importance.…”

Section: Introductionmentioning

confidence: 99%

Fast and Simultaneous Determination of the Number and Mass Concentrations of Gold Nanorod Colloid Using an Improved Optical Extinction-Scattering Spectroscopic Method

et al. 2016

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Accurate determination of the concentrations, including the mass concentration (MC) and number concentration (NC), of metal nanoparticle (NP) colloid is highly demanded in the synthesis, metrology, and application of NPs. The commonly used inductively coupled plasma mass spectrometry (ICP-MS) can only measure the MC of NPs, which is destructive to the NPs and requires advanced operation skills. Here, we present a simple approach based on an improved optical extinction-scattering spectroscopic (OESS) method to fast determining the MC and NC of metal nanorod colloids simultaneously. Unlike most existing spectroscopic methods that can only deal with low-concentration NP colloids, the improved OESS method can accurately solve the inverse scattering problem of NP colloids with higher concentrations, so that a two-dimensional joint probability density function of both the width and aspect ratio of nanorods can be retrieved, which makes the basis for the accurate determination of the MC and NC of the colloids in a large range of concentration. The reliability and accuracy of the method are validated by measuring several typical nanorod colloids with different concentrations and comparing the results with those obtained by the standard ICP-MS method. It is shown that the improved OESS method can cover a broad MC measurement range of at least 10-50 µg/mL and a NC measurement range of 10(9)-10(11)/mL. The uncertainty and sources of error in the measurement are also analyzed. Since the improved OESS method is fast, cost-effective, non-destructive, and easy to implement, it provides a simple way to determine the concentrations of metal NPs and has the potential to be extended to other metal NPs.

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Effect of concentration on the plasmonic absorption and optical nonlinearity of gold nanoparticles

Cited by 16 publications

References 24 publications

Enhancement of gold nanorods‐assisted photothermal treatment on cancer with laser power in stepwise modulation

Enhancement of gold nanorods‐assisted photothermal treatment on cancer with laser power in stepwise modulation

Dependence of Laser Ablation Produced Gold Nanoparticles Characteristics on the Fluence of Laser Pulse

Fast and Simultaneous Determination of the Number and Mass Concentrations of Gold Nanorod Colloid Using an Improved Optical Extinction-Scattering Spectroscopic Method

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