Effect of Concentrated Growth Factor on Distraction Osteogenesis of Dental Implant Distractors

Yin, Xuelai; Shi, Huan; Hze-Khoong, Eugene Poh; Hu, Yan; Zhang, Chenping

doi:10.1016/j.joms.2021.12.017

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Various growth factors captured after preparation can be released slowly in the later rhythm, making CGF have broad clinical application prospects in the field of pulp injury repair and tissue engineering regeneration [22] . Its application in bone defects can effectively promote angiogenesis, periosteal cell proliferation and bone tissue repair [23] .…”

Section: Cgfmentioning

confidence: 99%

Application of filling materials in autologous tooth transplantation

2023

FMSR

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As a treatment method for replacing missing teeth, autologous tooth transplantation (ATT)has shown more indications and ideal clinical effects with the continuous development of mature clinical applications and new technologies. The initial stability is an important factor to promote the healing of periodontal ligament. However, due to the fact that the alveolar fossa in the recipient area is difficult to completely match the donor tooth, and there will be different sizes of defect space around the root of the donor tooth after transplantation, which makes the transplanted tooth loose obviously, fall off and fail. This article reviews and analyzes the filling materials used in tooth transplantation.

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Section: Cgfmentioning

confidence: 99%

Application of filling materials in autologous tooth transplantation

2023

FMSR

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“…CGF can promote cell proliferation, migration, and differentiation [ 23 , 24 ], as well as angiogenesis [ 25 ] and osteogenesis [ 26 ], all of which show great potential in tissue regeneration. CGF has been investigated to be effective in the treatment of bone defects [ 19 , 27 ], implantology [ 28 ], gingival recession [ 29 ] and temporomandibular disorders [ 30 ]. However, due to insufficient randomized controlled trials (RCTs) for meta-analysis, only a few reviews [ 31 – 35 ] have reported the effect of CGF on oral and maxillofacial tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

Chen,

Cheng,

Cai

et al. 2023

BMC Oral Health

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Background Concentrated growth factor (CGF), a new autologous platelet concentrate, has been widely investigated to the adjunctive treatment of oral diseases. This study aims to evaluate the efficacy of CGF in the surgical treatment of oral diseases. Methods MEDLINE, Web of Science, Scopus, Cochrane, and EMBASE databases were searched up to July 2023. Only randomized clinical trials were included. The methodologic quality was evaluated by the Cochrane Risk of Bias Tool. RevMan 5.4 software was used for data analysis. Results In the treatment of periodontal intrabony defects, bone graft combined with CGF was significantly superior to bone graft (P < 0.01), with mean intrabony defect depth reduction of 1.41 mm and mean clinical attachment level gain of 0.55 mm. In the regenerative surgery of furcation defects, the effect of CGF group was significantly better than control group (P < 0.0001), with mean probing depth reduction of 0.99 mm, vertical bone gain of 0.25 mm, and horizontal bone gain of 0.34 mm. CGF combined with coronally advanced flap (CAF) was more effective than CAF alone (mean keratinized tissue width increase of 0.41 mm, mean gingival thickness increase of 0.26 mm, P < 0.00001), but less effective than connective tissue graft (CTG) combined with CAF (mean root coverage difference of -15.1%, mean gingival thickness difference of -0.5 mm, P < 0.0001). In the alveolar ridge preservation, additional use of CGF reduced horizontal bone resorption by 1.41 mm and buccal vertical bone resorption by 1.01 mm compared to control group (P < 0.0001). The VAS score of CGF group was significantly lower than that of the control group at the 1st and 7th day after oral surgery (P < 0.0001). Conclusions CGF can exert a positive adjunctive effect for the regenerative surgery of periodontal intrabony defects, furcation defects, and alveolar ridge preservation procedure. CGF combined with CAF has a better therapeutic effect on gingival recession compared to CAF alone, although it is not as effective as CTG combined with CAF. CGF could promote postoperative healing and pain relief in oral surgery within a week. There is currently not enough evidence to support the clinical benefits of CGF in other oral surgeries.

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The effects of SDF-1 combined application with VEGF on femoral distraction osteogenesis in rats

Fu,

Li,

Yang

et al. 2024

Open Life Sciences

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Bone regeneration and mineralization can be achieved by means of distraction osteogenesis (DO). In the present study, we investigated the effect of stromal cell-derived factor 1 (SDF-1) and vascular endothelial growth factor (VEGF) on the new bone formation during DO in rats. Forty-eight Sprague–Dawley rats were randomized into four groups of 12 rats each. We established the left femoral DO model in rats and performed a mid-femoral osteotomy, which was fixed with an external fixator. DO was performed at 0.25 mm/12 h after an incubation period of 5 days. Distraction was continued for 10 days, resulting in a total of 5 mm of lengthening. After distraction, the solution was locally injected into the osteotomy site, once a day 1 ml for 1 week. One group received the solvent alone and served as the control, and the other three groups were treated with SDF-1, VEGF, and SDF-1with VEGF in an aqueous. Sequential X-ray radiographs were taken two weekly. The regeneration was monitored with the use of micro-CT analysis, mechanical testing, and histology. Radiographs showed accelerated regenerate ossification in the SDF-1, VEGF, and SDF-1 with the VEGF group, with a larger amount of new bone compared with the control group, especially SDF-1 with the VEGF group. Micro-CT analysis and biomechanical tests showed Continuous injection of the SDF-1, VEGF, and SDF-1 with VEGF during the consolidation period significantly increased bone mineral density bone volume, mechanical maximum loading, and bone mineralization of the regenerate. Similarly, the expression of osteogenic-specific genes, as determined by real-time polymerase chain reaction , was significantly higher in SDF-1 with the VEGF group than in the other groups. Histological examination revealed more new trabeculae in the distraction gap and more mature bone tissue for the SDF-1 with the VEGF group. SDF-1 and VEGF promote bone regeneration and mineralization during DO, and there is a synergistic effect between the SDF-1 and VEGF. It is possible to provide a new and feasible method to shorten the period of treatment of DO.

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Effect of Concentrated Growth Factor on Distraction Osteogenesis of Dental Implant Distractors

Cited by 3 publications

References 23 publications

Application of filling materials in autologous tooth transplantation

Application of filling materials in autologous tooth transplantation

Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

The effects of SDF-1 combined application with VEGF on femoral distraction osteogenesis in rats

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