Effect of Complex Treatment of Gingivitis With the Use of Chewing Phytosubstrate in Women With Emergencies Caused by Pregnancy on the Content of Proinflammatory Cytokines in the Oral Fluid

Abstract

Introduction. Edema of pregnant women is a pathological condition in the second half of pregnancy, in which disorders of the functions of vital organs are noted and an exacerbation of chronic and sluggish inflammatory diseases occurs. Inflammatory periodontal disease and dental caries increase especially in the third trimester, and are most pronounced in complicated pregnancies. Changes in the cytokine profile in the mixed saliva of pregnant women reflect the state of local immunity and tissues of the oral cavity and indicate the participation of immunocompetent cells of the placenta and fetus in the response to the inflammatory process.
 Purpose: to characterize the effect of complex treatment of gingivitis with the use of a chewing phytosubstrate in women with edema caused by pregnancy on the level of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) in the oral fluid.
 Materials and methods: the level of cytokines IL-1β, IL-6, TNF-α in the oral fluid was determined before and after complex treatment of gingivitis with the inclusion of a chewing phytosubstrate in women with edema caused by pregnancy.
 Conclusion: Inclusion in the complex treatment of gingivitis in women with edema caused by pregnancy, a chewable phytosubstrate containing 0.1 g of dry matter extract (oak bark, alder stems, birch buds, chamomile flowers, thyme grass) and 1.0 g beeswax, has a pronounced therapeutic effect, reducing the content of pro-inflammatory cytokines in the oral fluid, which reflects the suppression of the inflammatory process.