Effect of combined vitamin D administration plus dietary intervention on oxidative stress markers in patients with metabolic syndrome: A pilot randomized study

Effects of Vitamin D Supplementation on Lipid Profile in Adults with the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…Characteristics of included studies are given in Table 1. The studies by Makariou [30][31][32] were conducted on the same sample, but reported on different outcomes in three different manuscripts.…”

“…Three of the studies were conducted in Greece [30][31][32], two in Iran [33,34], one in Thailand [33] and one in China [34]. The number of trial participants varied from 50 to 123, and a mean age ranging between 40 and 65 years.…”

“…The number of trial participants varied from 50 to 123, and a mean age ranging between 40 and 65 years. All of the studies were conducted on participants suffering from the MetS, diagnosed either by the NCEP-ATP III [30][31][32][33][34], the IDF [35], or the joint interim statement between several major organizations [36]. The follow-up period varied from 8 weeks [33] to 1 year [34].…”

“…In three studies, the intervention consisted of vitamin D3 supplementation with dietary intervention [30][31][32], one study used vitamin D (without specifying its type) supplementation with physical activity [35], two studies supplemented only with vitamin D3 [34,36], and one study supplemented with vitamin D2 [33]. The average daily dose of VDS ranged from 700 IU [34] to 7142.85 IU [36], whereby four studies were supplemented with 2000 IU per day [30][31][32]35]. Four RCTs were placebo-controlled [33][34][35][36], and in the other three RCTs [30][31][32], the comparator was dietary intervention according to the NCEP-ATP III guidelines.…”

“…The average daily dose of VDS ranged from 700 IU [34] to 7142.85 IU [36], whereby four studies were supplemented with 2000 IU per day [30][31][32]35]. Four RCTs were placebo-controlled [33][34][35][36], and in the other three RCTs [30][31][32], the comparator was dietary intervention according to the NCEP-ATP III guidelines. Only Yin et al [34] included a co-intervention in the form of calcium supplementation.…”