Effect of combined vaccination for &lt;i&gt;Pasteurella multocida&lt;/i&gt;, &lt;i&gt;Mannheimia haemolytica&lt;/i&gt;, and &lt;i&gt;Histophilus somni&lt;/i&gt; to prevent respiratory diseases in young Japanese Black calves in the field

Nagai, Katsuhisa; Otomaru, Konosuke; Ogawa, Rei; Oishi, Shoko; Wataya, Kenta; Honkawa, Yusuke; Iwamoto, Yuki; Ando, Takaaki; Hyakutake, Koji; Shirahama, Hiroto; Habiby, Gulhabib; Kubota, Chikara

doi:10.1292/jvms.19-0256

Cited by 6 publications

(6 citation statements)

References 15 publications

(18 reference statements)

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“…These four factors were previously found to be strongly associated with the health status of calves (6,8,17,18). It has already been reported that a significant reduction in the incidence of respiratory disease as well as higher antibody titres in responses detected using the same antigen were observed in calves immunised with the same vaccine as the one used in this study (16). Therefore, early immunisation probably mitigates BRD in young calves, and the health status of calves at immunisation is very important for preventing BRD.…”

Section: Discussionsupporting

confidence: 69%

“…Blood samples were collected into plain vacutainer tubes and centrifuged at 3,500 rpm for 8 min, and the serum was isolated. Serum was maintained at −30℃ until analysis and serum antibodies against H. somni , P. multocida and M. haemolytica were detected using an ELISA as previously described ( 16 ). When the antibody titres for P. multocida and M. haemolytica were detected with less than a 100-fold dilution, they were calculated as a 50-fold dilution.…”

Section: Methodsmentioning

confidence: 99%

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Field trial of antibody response to inactivated bacterial vaccine in young Holstein calves: influence of animal health status

Mori

Otomaru

Kato

et al. 2022

Journal of Veterinary Research

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Introduction Bovine respiratory disease (BRD) is one of the primary causes of death in young calves. Vaccination against infection by the common bacteria causing BRD is possible; however, the physical condition of the young calves that enables antibody production when stimulated by early immunisation remains to be elucidated. Material and Methods Healthy young female Holstein calves on a commercial dairy farm were fed a colostrum replacer and administered primary and booster immunisations with an inactivated vaccine against the bacterial pneumonia agents Histophilus somni, Pasteurella multocida and Mannheimia haemolytica. At each immunisation, the body weight and height at the withers were measured and the body mass index (BMI) was calculated. Blood was sampled immediately before immunisation and 3 weeks following the booster. The calves were divided into positive and negative groups based on the antibody titre at the final blood sampling. Maternal antibody titres at the primary immunisation and BMI, nutritional status and oxidative stress at both immunisations were compared between the two groups. Results Antibody titre at the primary and BMI at both immunisations were significantly higher in the positive than in the negative group (P < 0.05). Additionally, serum gamma globulin was significantly higher in the positive group (P < 0.05), indicating a strong correlation between maternal antibody and serum gamma globulin levels. Conclusion Elevated maternal antibody titre and higher BMI are positive factors for successful early immunisation, for which suitable colostrum may also be fundamental in young calves administered inactivated vaccines.

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Section: Discussionsupporting

confidence: 69%

Section: Methodsmentioning

confidence: 99%

Field trial of antibody response to inactivated bacterial vaccine in young Holstein calves: influence of animal health status

Mori

Otomaru

Kato

et al. 2022

Journal of Veterinary Research

Self Cite

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“…Blood samples were collected into plain vacutainer tubes and centrifuged at 3,500 rpm for eight min, and then blood serum was isolated. Serum was kept at −30°C until analysis and serum antibodies against H. somni, P. multocida, and M. haemolytica were detected using ELISA as described in a previous study (15). For P. multocida and M. haemolytica, when the antibody titre was detected with less than 100-fold dilution, it was calculated as a 50-fold dilution.…”

Section: Methodsmentioning

confidence: 99%

Field trial of primary and booster dose of inactivated vaccine against bovine respiratory bacteria in young Holstein calves

Mori

Kato

Yokota³

et al. 2020

Journal of Veterinary Research

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AbstractIntroductionThe objective of this research was to evaluate the antibody response to multiple doses of an inactivated mixed vaccine against Histophilus somni, Pasteurella multocida, and Mannheimia haemolytica, and to investigate the influence of age at time of vaccination in the field.Material and MethodsHealthy female Holstein calves received the vaccine at the age of 5–12 days and 2, 3, or 4 weeks later in the first experiment or at 1, 2, or 3 weeks of age and 4 weeks later in the second. Blood samples were collected at each vaccination and 3 weeks after the booster dose. Based on the antibody titres after the vaccinations, calves were divided into positive and negative groups for each of the bacteria. Calves in the control group were vaccinated only once at the age of 19–26 days.ResultsAntibody titres against H. somni and P. multocida were significantly increased by the booster. After the second vaccinations, the titres against each bacterium were higher than those of the control group, and the M. haemolytica-positive percentage in calves with high maternal antibody levels (MAL) exceeded that in calves with low MAL. In the first experiment, a majority of the M. haemolytica-positive calves tended to have received the primary dose at seven days of age or older.ConclusionA booster dose of the inactivated bacterial vaccine in young Holstein calves increased antibody production and overcame the maternal antibodies. Calves should be vaccinated first at seven days of age or older.

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“…Challenge studies, whilst important for determining the potential for a vaccine to be effective, have the disadvantages of an atypical environment and unnatural timings of pathogen exposure. Certain field trials have reported significantly lowered morbidity and mortality in vaccinated calves compared to non-vaccinated calves with multivalent vaccines against [ 133 , 134 , 135 ]. However, there is a lack of field trials investigating the prevention of BRDC for the many vaccines that have been developed.…”

Section: Vaccination Challengesmentioning

confidence: 99%

The Bacterial and Viral Agents of BRDC: Immune Evasion and Vaccine Developments

Bell¹,

Turkington²,

Cosby³

2021

Vaccines

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Bovine respiratory disease complex (BRDC) is a multifactorial disease of cattle which presents as bacterial and viral pneumonia. The causative agents of BRDC work in synergy to suppress the host immune response and increase the colonisation of the lower respiratory tracts by pathogenic bacteria. Environmental stress and/or viral infection predispose cattle to secondary bacterial infections via suppression of key innate and adaptive immune mechanisms. This allows bacteria to descend the respiratory tract unchallenged. BRDC is the costliest disease among feedlot cattle, and whilst vaccines exist for individual pathogens, there is still a lack of evidence for the efficacy of these vaccines and uncertainty surrounding the optimum timing of delivery. This review outlines the immunosuppressive actions of the individual pathogens involved in BRDC and highlights the key issues in the development of vaccinations against them.

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Effect of combined vaccination for <i>Pasteurella multocida</i>, <i>Mannheimia haemolytica</i>, and <i>Histophilus somni</i> to prevent respiratory diseases in young Japanese Black calves in the field

Cited by 6 publications

References 15 publications

Field trial of antibody response to inactivated bacterial vaccine in young Holstein calves: influence of animal health status

Field trial of antibody response to inactivated bacterial vaccine in young Holstein calves: influence of animal health status

Field trial of primary and booster dose of inactivated vaccine against bovine respiratory bacteria in young Holstein calves

The Bacterial and Viral Agents of BRDC: Immune Evasion and Vaccine Developments

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