Effect of Combined Probiotics and Zinc Supplementation on Immune Status of Pulmonary Tuberculosis Patients

Setiyaning, Zulia; Darmono, S.S.; Sofro, Muchlis Achsan Udji; Dharmana, Edi; Widyastiti, Nyoman Suci

doi:10.3923/pjn.2016.680.685

Cited by 4 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies showed that probiotics could decrease inflammatory response in Crohn's disease and food allergy by increasing anti-inflammatory cytokines and decreasing pro-inflammatory cytokines; while zinc supplementation in tuberculosis patients could increase their nutritional status, haemoglobin level, and plasma zinc, and also increase immunity in human immunodeficiency virus (HIV) patients. A combination between zinc and probiotics increases the immune system by increasing lymphocyte levels and decreasing levels of monocytes and neutrophilto-lymphocyte ratio (NLR) (Widiastuti, Darmono & Sofro, 2019;Setiyaningrum, Darmono & Sofro, 2016). Another study showed that the combination of zinc and probiotics was more effective in resolving diarrhoea in children under five years old than in children who received zinc supplementation only (Surono et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effect of zinc and probiotics supplementation on IL-6 and tissue neutrophil levels in rats exposed to cigarette smoke

Andryani,

Mahati,

Tjahjono

et al. 2023

Mal J Nutr

View full text Add to dashboard Cite

Introduction: Cigarette smoke exposure can cause inflammation, inducing the release of acute phase cytokines, such as IL-6, that will then trigger the recruitment of neutrophils, which are mostly phagocytic cells. Zinc and probiotics are known to have beneficial effects against inflammation. This study was conducted to investigate the effect of zinc and probiotics supplementation on IL-6 and tissue neutrophil levels in rats exposed to cigarette smoke. Methods: In a randomised, experimental study with post-test control group design, thirty 2 to 3-month-old male Wistar rats, each weighing 180-220 g, were divided into five groups: control group without treatment (C); exposed to cigarette smoke [C (-)]; exposed to cigarette smoke and received zinc (Z); exposed to cigarette smoke and received probiotics (P); and exposed to cigarette smoke and received a combination of zinc and probiotics (ZP). Results: Mean tissue neutrophil levels in Z, P, and ZP groups were 43.43±2.01, 34.67±1.32, and 29.77±5.05 cells, respectively. There were significant differences between supplementation intake and tissue neutrophil levels in each group compared to C (-) group (p<0.05). Meanwhile, only IL-6 level in the ZP group (6.02 pg/mL) decreased significantly compared to C (-) group (10.61 pg/mL). Conclusion: These results suggest that a combination of zinc and probiotics have an anti-inflammatory effect as measured by IL-6 and neutrophil levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of zinc and probiotics supplementation on IL-6 and tissue neutrophil levels in rats exposed to cigarette smoke

Andryani,

Mahati,

Tjahjono

et al. 2023

Mal J Nutr

View full text Add to dashboard Cite

show abstract

“…Infeksi mengakibatkan inflamasi kronis, penurunan asupan, malabsorpsi nutrient, perubahan metabolisme tubuh dan radikal bebas, immunitas tubuh dan antioksidan tubuh menurun. 7,8 Obat-obat TBC berspektrum antibiotik kuat, menyebabkan kerusakan pada saluran pencernaan pada makroflora usus, penurunan penyerapan zat gizi, menurunnya respon imun tubuh yang disertai dengan penurunan status gizi dan nafsu makan penderita dan penyebab mual, muntah, diare, tidak nafsu makan, peningkatan suhu tubuh dan penurunan makroflora usus. 9 Pasien tuberculosis paru, mengalami penurunan status gizi disebabkan tingkat perilaku terhadap makanan dan kesehatan, khususnya kecukupan energi dan protein, lama menderita penyakit paru, serta pendapatan perkapita pasien.…”

Section: Copyright @2019 P-issn : 2337-6236; E-issn : 2622-884xunclassified

“…9 Pasien tuberculosis paru, mengalami penurunan status gizi disebabkan tingkat perilaku terhadap makanan dan kesehatan, khususnya kecukupan energi dan protein, lama menderita penyakit paru, serta pendapatan perkapita pasien. 5,7,9 Perbaikan gizi upaya untuk memutus lingkaran setan penularan dan pemberantasan tuberculosis.…”

Pengaruh Supplementasi Probiotik Dan Selenium Terhadap Respon Imun NLR (Neutrophil Lymphocyte Count Ratio) , Haemoglobin Dan Albumin Pada Tikus Wistar Yang Diinduksi Mycobakterium Tuberculosis

2019

Self Cite

View full text Add to dashboard Cite

Latar belakang : Penyakit tuberkulosis (TBC) paru merupakan masalah kesehatan masyarakat global termasuk Indonesia. Penyakit tuberkulosis paru pada umumnya terjadi malnutrisi akibat efek samping obat anti tuberculosis, yang menyebabkan gangguan saluran cerna dan respon imunitas. Probiotik dan Selenium diduga memiliki efek menguntungkan respon imunitas dan status gizi pada pasien terinfeksi tuberculosisTujuan : Untuk menganalisis pengaruh pemberian suplementasi probiotik dan selenium terhadap NLR ( Neutrophill Ratio Lymphocyte ), Hemoglobin dan Albumin pada tikus wistar yang diinduksi Mycobacterium tuberculosis.Metode : Penelitian eksperimen dengan rancangan Randomized Post test Control Group Design. Dua puluh delapan tikus Wistar dibagi 4 kelompok, kelompok 1 : kelompok kontrol hanya diberikan OAT, kelompok 2 : probiotik + OAT, kelompok 3 : selenium + OAT serta kelompok 4 : probiotik dan selenium + OAT. Setelah diinduksi 14 hari, hewan diberikan perlakuan selama 28 hari. Analisis data menggunakan Anova, Post Hoc atau Kruskal Wallis, Mann Whitney pada tingkat kemaknaan p<0.05. Hasil : Terjadi penurunan kadar NLR, peningkatan kadar Hemoglobin dan Albumin pada tikus kelompok 1 (p<0.05), kelompok 2 (p<0.05) serta kelompok 3 (p<0.05). Efektifitas pemberian probiotik dan selenium paling kuat terdapat pada NLR, Hemoglobin dan AlbuminSimpulan : Suplementasi probiotik dan selenium selama 28 hari mampu meningkatkan sistem imunitas ( NRL ), Hemoglobin dan Albumin pada kelompok perlakuan lebih baik dibanding kelompok kontrol.

show abstract

Role of the gut microbiome and probiotics for prevention and management of tuberculosis

Baral

Kurian²,

M.³

et al. 2022

Microbiome, Immunity, Digestive Health and Nutrition

View full text Add to dashboard Cite

Effect of Combined Probiotics and Zinc Supplementation on Immune Status of Pulmonary Tuberculosis Patients

Cited by 4 publications

References 3 publications

Effect of zinc and probiotics supplementation on IL-6 and tissue neutrophil levels in rats exposed to cigarette smoke

Effect of zinc and probiotics supplementation on IL-6 and tissue neutrophil levels in rats exposed to cigarette smoke

Pengaruh Supplementasi Probiotik Dan Selenium Terhadap Respon Imun NLR (Neutrophil Lymphocyte Count Ratio) , Haemoglobin Dan Albumin Pada Tikus Wistar Yang Diinduksi Mycobakterium Tuberculosis

Role of the gut microbiome and probiotics for prevention and management of tuberculosis

Contact Info

Product

Resources

About