Effect of Combined Œstrogen-Progestogen Oral Contraceptives, Œstrogen, and Progestogen on Antiplasmin and Antithrombin Activity

Howie, P. W.; Prentice, C. R. M.; Mallinson, Annette C.; Horne, C. H. W.; McNicol, G. P.

doi:10.1016/s0140-6736(70)92358-5

Cited by 117 publications

(41 citation statements)

References 32 publications

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“…The influence of oral contracep tives on the plasma plasminogen level is less well established. Whereas P hillips et al [26], H ow ie et al [14] and A mris and Starup [3] ob served an increase in the plasminogen level, Brakman and A strup [4] found no difference in the mean plasminogen level between hormonetreated and control women. Our results support the former conclusion.…”

Section: Discussionmentioning

confidence: 93%

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Interrelations between ABO Blood Group, Plasminogen, α1-Antitrypsin, α2-Macroglobulin and the Platelet Count in Blood Donors

Dawson¹,

Allardyce²,

Allan³

et al. 1976

Acta Haematol

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The levels of plasminogen, α₁-antitrypsin, α₂-macroglobulin and the platelet count were measured in 511 blood donors. The mean level of α₁-antitrypsin was significantly lower in men of group B compared with that of group O. No other differences between the blood groups reached statistical significance. Women had higher mean levels of α₁-antitrypsin and α₂-macroglobulin and a higher platelet count than men. The levels of plasminogen and α₁-antitrypsin were significantly higher in women using oral contraceptives compared with those who were not. The level of α₂-macroglobulin fell with age until the 60–64 year age-group in men and the 40–49 year age-group in women. A positive correlation existed between the α₁-antitrypsin and the α₂-macroglobulin level and between the platelet count and the plasminogen level.

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Section: Discussionmentioning

confidence: 93%

“…A rise in «2-macroglobulin and «,-antitrypsin during oestrogen-progestogen therapy has been well documented [13,14,18]. The influence of oral contracep tives on the plasma plasminogen level is less well established.…”

Section: Discussionmentioning

confidence: 99%

Interrelations between ABO Blood Group, Plasminogen, α1-Antitrypsin, α2-Macroglobulin and the Platelet Count in Blood Donors

Dawson¹,

Allardyce²,

Allan³

et al. 1976

Acta Haematol

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show abstract

“…This syndrome has been associated with many disparate conditions, such as pregnancy toxaemia, septicaemia, amniotic fluid embolism, hypertension, snake bite and shock (e.g., the reviews by Pitney, 1971 and Simpson and Stalker, 1973 Pregnancy is associated with changes in the fibrinogen/plasminogen system, although the details are still subject to dispute probably related to technical differences (Woodfield et al, 1968;Bonnar et al, 1969). A variety of changes in coagulation factors and their inhibitors have been observed in patients receiving oestrogen-progestogen preparations (e.g., Brackman and Astrup, 1964;Ygge et al, 1969;Howie et al, 1970). Whereas the precise mechanism of an enhanced thrombotic tendency is still disputed, its existence is sufficiently well established to provide a good theoretical basis for the observed clinical association, particularly related to the oestrogen content of the pill (British Medical Journal, 1974).…”

Section: Discussionmentioning

confidence: 99%

Pancreatitis, multiple infarcts and oral contraception

Foster

Powell

1975

Postgraduate Medical Journal

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Summary The fact that oral contraceptives may predispose to thrombosis is not disputed, although its frequency is still debated. Any reliable assessment of the prevalence of this complication must in the main depend on careful statistical studies of well controlled groups, because the isolated case may well be coincidental when conditions such as coronary thrombosis, cerebral thrombosis, and pulmonary embolism are not extreme rarities in adult women. However, occasionally the clinical and pathological findings are so striking that they afford compelling evidence. The patient to be described presented with clinical features of pancreatitis that did not initially suggest an association with oral contraception. A hitherto undescribed state of multiple infarcts was found at post-mortem. This also illustrates the way in which the official figures for thrombotic complications can be underestimated.

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“…Antithrombin III (AT III) activity fell significantly during OCP useand the estrogen component was blamed for the fall 13,14 . Low serum ATIII activity was observed in patients with pulmonary embolism,MI and venous thrombosis.…”

Section: Original Articlesmentioning

confidence: 99%

Effect of Low Dose Oral Contraceptive Pill on Coagulation Status in Women with Normal and Low Body Mass Index

Kasem¹,

Chowdhury²,

Razzaque³

et al. 2017

J. Bangladesh Coll. Phys.

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Effect of Combined Œstrogen-Progestogen Oral Contraceptives, Œstrogen, and Progestogen on Antiplasmin and Antithrombin Activity

Cited by 117 publications

References 32 publications

Interrelations between ABO Blood Group, Plasminogen, α<sub>1</sub>-Antitrypsin, α<sub>2</sub>-Macroglobulin and the Platelet Count in Blood Donors

Interrelations between ABO Blood Group, Plasminogen, α<sub>1</sub>-Antitrypsin, α<sub>2</sub>-Macroglobulin and the Platelet Count in Blood Donors

Pancreatitis, multiple infarcts and oral contraception

Effect of Low Dose Oral Contraceptive Pill on Coagulation Status in Women with Normal and Low Body Mass Index

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