Effect of Combined Intracoronary Adenosine and Nicorandil on No-Reflow Phenomenon During Percutaneous Coronary Intervention

Coronary microvascular reperfusion injury and no-reflow in acute myocardial infarction

“…Intracoronary administration of adenosine combined with nicorandil may improve both the occurrence of no-reflow in patients during PCI for AMI and short-term clinical outcome, compared with adenosine alone. 71 Nicorandil has KATP channel opener-like and nitrate-like properties at ischemia-reperfusion. In addition to its direct beneficial effect on improving hemodynamics, scavenging free radicals and inhibiting neutrophil activation, nicorandil induces an early reduction of the ischemic preconditioning (PC) threshold to reduce infarct size.…”

Impact of PercuSurge Device Conjugative With Intracoronary Administration of Nitroprusside on No-Reflow Phenomenon Following Primary Percutaneous Coronary Intervention

“…33,34 However, without a comparison, we can not provide additional information that these drugs are superior to NTP or vice versa for reversing slow-flow or no-reflow phenomenon during primary PCI. Second, although the half life of NTG is very short (<2 min) and the time period between NTG and NTP administration was 5 min, this study can not completely rule out a synergic effect of the 2 drugs on vasodilatation.…”

Adaptive Phenomenon of Ischemic Postconditioning of the Heart. Perspectives of Clinical Use

“…Активность КФК оказалась ниже у пациентов, получавших аденозин, у них же были лучше показатели сократимости миокарда, частота неблагопри-ятных событий была ниже, чем в контрольной группе (ангиопластика без аденозина) [67]. Кардиопротектор-ный эффект аденозина у пациентов с ОИМ был под-твержден в более поздних клинических исследованиях [68][69][70]. Вместе с тем некоторые авторы сообщают [70], что аденозин не вызывает улучшения насосной функции сердца в реперфузионном периоде, снижение летально-сти после его применения хоть и достоверно, но незна-чительно.…”