2019
DOI: 10.5487/tr.2019.35.2.155
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Effect of Combined Exposure to EDTA and Zinc Pyrithione on Pyrithione Absorption in Rats

Abstract: Zinc pyrithione (ZnPT) is a coordination complex of zinc and has been used widely as an anti-dandruff agent in shampoos. Many shampoos contain both ZnPT and EDTA, a chelating agent speculated to increase ZnPT absorption, thereby raising concerns about neurotoxicity. Here, we investigated the effect of EDTA on ZnPT absorption by direct comparison of ZnPT and pyrithione (PT) concentrations in shampoo formulations, and by pharmacokinetic analysis of ZnPT, PT, and 2-methanesulfonylpyridine (MSP), the main ZnPT met… Show more

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Cited by 3 publications
(3 citation statements)
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“…The dermal absorption rate is crucial for the risk assessment of cosmetics majorly absorbed through the skin [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ] Several factors affect dermal absorption, such as donor characteristics, including gender [ 9 ], disease [ 10 ], age [ 11 ], race [ 12 ], vehicle [ 13 ], test substances (physicochemical properties, particle size) [ 14 , 15 ], skin condition [ 16 ], hydration [ 17 ], pH [ 18 ], stress [ 19 ], and physical or chemical damage [ 20 ], etc.…”
Section: Introductionmentioning
confidence: 99%
“…The dermal absorption rate is crucial for the risk assessment of cosmetics majorly absorbed through the skin [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ] Several factors affect dermal absorption, such as donor characteristics, including gender [ 9 ], disease [ 10 ], age [ 11 ], race [ 12 ], vehicle [ 13 ], test substances (physicochemical properties, particle size) [ 14 , 15 ], skin condition [ 16 ], hydration [ 17 ], pH [ 18 ], stress [ 19 ], and physical or chemical damage [ 20 ], etc.…”
Section: Introductionmentioning
confidence: 99%
“…Systemic exposure to ZnPT after topical dosing has been studied in humans and a range of animal species including rat, rabbit, monkey and guinea pig ( Table 4 ) [ 12 , 143 , 165 , 177 , 181 , 182 ]. Exposure can be estimated in ex vivo Franz cell studies from the amount of ZnPT that permeates into the receptor phase or can also be investigated in vivo with urine or blood serum analysis.…”
Section: Toxicity Assessmentmentioning
confidence: 99%
“…Radiolabeling studies and more recently studies using liquid chromatography mass spectrometry [177] have been performed to determine the systemic exposure of ZnPT after topical application. The organic (pyrithione) and inorganic (zinc) moieties of ZnPT can be differentially labelled using isotopes of [ 14 C] or [ 35 S] and [ 65 Zn], respectively.…”
Section: Systemic Exposure Following Topical Applicationmentioning
confidence: 99%