Effect of combination therapy with systemic glucantime and pentoxifylline in the treatment of cutaneous leishmaniasis

Abstract

The result obtained by two therapeutic methods indicates that combined therapy with Glucantime and pentoxifylline is more effective than Glucantime alone (P < 0.05).

Treatment of acute Old World cutaneous leishmaniasis: A systematic review of the randomized controlled trials

“…Sadeghian and Nilforoushzadeh 41 reported that combined treatment with oral pentoxifylline (400 mg thrice daily) and a 2-week standard course of intramuscular MA injections was more effective than MA injections alone (P \ .05). Asilian et al, 46 in an RCT comprising a large sample, found carbon dioxide laser more effective than intramuscular injections of MA for 2 weeks (P \.05).…”

“…7,[40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58] Twenty-four RCTs are included in this group, two of which were also described in other groups. Predictably, this group was dramatically made up of heterogenic studies.…”

Clinical and Immunological Outcome in Cutaneous Leishmaniasis Patients Treated with Pentoxifylline

“…3,8 Pentoxifylline is a metilxantine used to treat vascular and chronic inflammatory diseases. 9,10 Pentoxifylline inhibits TNF-α production, 11 and the association of pentoxifylline plus antimony decreases the healing time of CL and ML, 12,13 is more effective than antimony alone, 10,11 and cures ML and CL patients refractory to Sb v therapy.…”

Cutaneous Leishmaniasis in Travellers: a Focus on Epidemiology and Treatment in 2015

“…In published RCTs, parenteral antimonials were equivalent or inferior to those administered intralesionally [22]. One small study suggests improved efficacy with adjunctive pentoxifylline (81.3 % n=26/32 vs. 50 % n=16/32) [49]. Despite poor evidence, experts endorse systemic antimonials in some national guidelines and continue to use them for complex, treatment refractory OWCL [47,98].…”