Effect of combination of nitric oxide synthase and cyclooxygenase inhibitors on carrageenan-induced pleurisy in rats

Sakaguchi, Yasue; Shirahase, Hiroaki; Kunishiro, Kazuyoshi; Ichikawa, Atsuko; Kanda, Mamoru; Uehara, Yoshio

doi:10.1016/j.lfs.2006.01.022

Cited by 21 publications

(19 citation statements)

References 24 publications

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“…In-vitro experiments showed that OPC had different effects on inflammation [12], which was probably due to the different structural characteristics of the molecules tested and the different experimental designs used. Adequate reports over decades revealed potent anti-inflammatory properties of OPC on experimental inflammation in rats and mice [13,14]. However, their anti-inflammatory mechanisms are poorly understood, which has been reported to be related to oxygen free radical scavenging, inhibition of the formation of inflammatory cytokines, and anti-lipid peroxidation [15,16].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of oligomeric proanthocyanidins against alcohol-induced liver steatosis and injury in mice

Wang

Fan

et al. 2015

Biochemical and Biophysical Research Communications

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Section: Introductionmentioning

confidence: 99%

Protective effect of oligomeric proanthocyanidins against alcohol-induced liver steatosis and injury in mice

Wang

Fan

et al. 2015

Biochemical and Biophysical Research Communications

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“…They function as powerful antioxidants and exert anti-inflammatory activities in vitro. Recent studies have shown potent anti-inflammatory properties of procyanidins on experimental inflammation in rats and mice [2,3]. Its mechanisms of anti-inflammatory action remain poorly understood and are relevant to oxygen free radical scavenging, antilipid peroxidation, inhibition of the formation of inflammatory cytokines, alterations in cell membranes receptors, intracellular signaling pathway proteins and modulation of gene expression [4].…”

Section: Introductionmentioning

confidence: 99%

Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet

Terra

Montagut

Bustos

et al. 2009

The Journal of Nutritional Biochemistry

279

198

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“…In addition, NO plays an important role in inflammation such as plasma exudation and leukocyte infiltration. The NO synthesis (NOS) inhibitors can reverse several classic inflammatory symptoms [5].…”

Section: Introductionmentioning

confidence: 99%

Anti‐Inflammatory effects of low‐level laser therapy (660 nm) in the early phase in carrageenan‐induced pleurisy in rat

et al. 2008

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Background and Objective: In the classic model of pleurisy there is little evidence about the anti-inflammatory effects of low-level laser therapy (LLLT) as well the dosage characteristics, such as wavelength, total energy, number and pattern of treatment. In this study we investigated the potential effects of LLLT on modulating the pro-inflammatory and anti-inflammatory mediators of acute inflammation in a rat pleurisy model. Study Design/Materials and Methods: A sample of 48 female Wistar rats were divided into control and experiential groups. An inflammation was induced by carrageenan (0.2 ml) injected into the pleural cavity. At 1, 2, and 3 hours after induction a continuous wave (20 mW) diode laser of the InGaAlP (660 nm) type was used in the four laser groups with different doses and treatment patterns. One group received a single dose of 2.1 J and the other three groups received a total energy of 0.9, 2.1, and 4.2 J. Four hours later the exudate volume, total and differential leukocytes, protein concentration, NO, IL-6, IL-10, TNF-a, and MCP-1 were measured from the aspirated liquid. Results: All the treatment patterns and quantity of energy studied show significant reduction of the exudate volume (P<0.05). Using energy of 0.9 J only NO, IL-6, MCP-1 and IL-10 are significantly reduced (P<0.05). On the other hand, higher energies (2.1 and 4.2 J) significantly reduce all variables independently of the treatment pattern. The neutrophil migration has a straight correlation with the TNF-a (r ¼ 0.551) and NO (r ¼ 0.549) concentration. Conclusions: LLLT-660 nm induced an anti-inflammatory effect characterized by inhibition of either total or differential leukocyte influx, exudation, total protein, NO, IL-6, MCP-1, IL-10, and TNF-a, in a dose-dependent manner. Under these conditions, laser treatment with 2.1 J was more effective than 0.9 and 4.2 J. Lasers Surg.

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Effect of combination of nitric oxide synthase and cyclooxygenase inhibitors on carrageenan-induced pleurisy in rats

Cited by 21 publications

References 24 publications

Protective effect of oligomeric proanthocyanidins against alcohol-induced liver steatosis and injury in mice

Protective effect of oligomeric proanthocyanidins against alcohol-induced liver steatosis and injury in mice

Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet

Anti‐Inflammatory effects of low‐level laser therapy (660 nm) in the early phase in carrageenan‐induced pleurisy in rat

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