Effect of colony-stimulating growth factor on outcome of frozen-thawed embryo transfer in patients with repeated implantation failure

Obidniak, D.; Gzgzyan, Alexandr; Dzhemlikhanova, Lyailya Kh.; Феоктистов, А. А.

doi:10.1016/j.fertnstert.2016.07.401

Cited by 11 publications

(3 citation statements)

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“…The included studies above totally enrolled 1966 participants (999 women were randomly allocated to treatment with G-CSF and 967 women were randomly allocated to placebo or no treatment.). A total of 13 of the above trials were published as full articles [ 31 – 43 ], seven were conference abstracts [ 44 – 50 ]. Eight trials were conducted in the Iran, three in India, three in Italy, one in Germany, one in Turkey, one in Russia，one in China, one in Egypt and one in USA.The sample size per study ranged from 28 to 157 participants.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of granulocyte colony-stimulating factor for infertility undergoing IVF: a systematic review and meta-analysis

Jin

et al. 2023

Reprod Biol Endocrinol

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Objective This study aimed to evaluate the effectiveness of granulocyte colony-stimulating factor (G-CSF) for infertility and recurrent spontaneous abortion. Methods Existing research was searched in PubMed, Embase and Cochrane Library till Dec 2021. Randomized control trials (RCTs) that compared G-CSF administration with the control group in infertility women undergoing IVF were included. The primary outcomes included clinical pregnancy rate; the secondary outcomes included live birth rate, abortion ratebiochemical pregnancy rate, embryo implantation rate, as well as endometrial thickness. Result(s) 20 RCTs were included in this study. G-CSF increased the clinical pregnancy rate (RR = 1.85; 95% CI: 1.07, 3.18) and the endometrial thickness (MD = 2.25; 95% CI: 1.58,2.92;) in patients with thin endometrium undergoing IVF. G-CSF increased the biochemical pregnancy rate (RR = 2.12; 95% CI: 1.54, 2.93), the embryo implantation rate (RR = 2.51; 95% CI: 1.82, 3.47) and the clinical pregnancy rate (RR = 1.93; 95% CI: 1.63, 2.29) in patients with a history of repeated implantation failure undergoing IVF. No differences were found in pregnancy outcomes of general IVF patients. Conclusions Granulocyte colony-stimulating factor is likely to be a potential option for infertility women undergoing IVF with thin endometrium or recurrent implantation failure . Trial registration Retrospectively registered (The PROSPERO registration number: CRD42022360161).

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Section: Resultsmentioning

confidence: 99%

Efficacy of granulocyte colony-stimulating factor for infertility undergoing IVF: a systematic review and meta-analysis

Jin

et al. 2023

Reprod Biol Endocrinol

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“…With these ten articles published between 2000 and 2016, 1036 IVF-ET patients in all were randomized, from a wide range of regions including Europe [ 16 , 18 , 21 , 31 ], North America [ 19 ] and Asia [ 17 , 20 , 22 , 23 , 30 ]. Among all studies, one evaluated the role of G-CSF treatment for unselected patients [ 19 ], one for the cases with thin endometrium [ 20 ], and remaining eight for those with RIF [ 16 – 18 , 21 – 23 , 30 , 31 ]. The detailed characteristics of these studies are shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Therapeutic role of granulocyte colony-stimulating factor (G-CSF) for infertile women under in vitro fertilization and embryo transfer (IVF-ET) treatment: a meta-analysis

Zhang

et al. 2018

Arch Gynecol Obstet

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ObjectiveThe aim of this meta-analysis is to explore the beneficial role of granulocyte colony-stimulating factor (G-CSF) on infertile women under artificial reproduction technology treatment.MethodMedline, Embase and ISI Web of Science databases were searched to identify relevant randomized control trials. Studies before July, 2017 were included for primary screening. Meta-analysis of the total and subgroup patients was conducted, and relative risks (RRs) and their 95% confidence intervals (95% CI) were calculated by a fixed-effect model if no heterogeneity (evaluated as I2 statistic) existed. Otherwise, a random-effects model was adopted. Subgroup analysis was performed by administrating route or clinical indication. Egger test and influence analysis were conducted to evaluate the publication bias and study power, respectively.ResultsThe final selection enrolled 10 RCTs, involving 1016 IVF-ET cycles (521 distributed to the G-CSF group and 495 to the control). Compared with control group, G-CSF administration could significantly improve clinical pregnancy rate (CPR, RR 1.89, 95% CI 1.53–2.33), while it had no beneficial effect on embryo implantation rate (IR, RR 1.84, 95% CI 0.84–4.03). The subgroup analysis by administration route showed that both uterine infusion and subcutaneous injection can produce a substantial increase in CPR, with the pooled RRs (95% CI) 1.46 (1.04–2.05) and 2.23 (1.68–2.95), respectively. Nevertheless, most of included RCTs dealt with the RIF subjects, and the pooled analysis of this data showed a higher PR and IR in G-CSF group as compared to that in the control, with the RRs (95% CI) 2.07 (1.64–2.61) and 1.52 (1.08–2.14), respectively. Egger regression test did not demonstrate any significance for the publication bias.ConclusionG-CSF administration has a beneficial role on the clinical outcome after embryo transfer by both routes of local infusion and systematic administration, especially for the cases with RIF. Further RCTs are needed to investigate the role of G-CSF in thin endometrium patients.Electronic supplementary materialThe online version of this article (10.1007/s00404-018-4892-4) contains supplementary material, which is available to authorized users.

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“…Other studies have also shown a significant improvement in implantation rates [11,13,14] and increment in clinical pregnancy rates [11,13,15]. Research comparing the intrauterine and subcutaneous routes found the subcutaneous route to be more efficacious [46]. A summary of studies on the effectiveness of G-CSF in RIF can be seen in Table 4.…”

Section: Reviewmentioning

confidence: 99%

Mediator in the Embryo-endometrium Cross-talk: Granulocyte Colony-stimulating Factor in Infertility

Robert

Abbas

Zaidi

et al. 2019

Cureus

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Successful implantation requires a receptive endometrium and a good quality egg. The challenges a physician encounters with regard to this in assisted reproductive technology are obtaining good quality embryo, achieving optimal endometrial thickness (EMT), and subsequently implantation, which is denotive of a receptive endometrium. Granulocyte colony-stimulating factor (G-CSF) has been observed to be a biomarker of oocyte quality and has been shown to enhance EMT and implantation because of its immunological effects. A systematic search for all relevant articles on G-CSF in follicular fluid and its therapeutic benefit in thin endometrium and recurrent implantation failure was performed, and peer-reviewed, full-text articles related to humans were included in the study. As a tool to determine the potentiality of oocyte, G-CSF shows promise with its predictability increasing in combination with morphological embryo scoring or interleukin 15. For the thin endometrium, G-CSF is especially useful in patients who are refractory to other treatment modalities. In recurrent implantation failure (RIF), G-CSF showed potential in a subset of patients with immunological deficiency lacking killer cell immunoglobulin-like receptor genes. This review highlights the various forms of usage of G-CSF and the effectiveness of G-CSF in infertility. G-CSF equips embryologists with a tool to determine the potentiality of oocyte and physicians with therapy for thin endometrium and RIF, especially since the available treatment options are ineffective.

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Effect of colony-stimulating growth factor on outcome of frozen-thawed embryo transfer in patients with repeated implantation failure

Cited by 11 publications

References 0 publications

Efficacy of granulocyte colony-stimulating factor for infertility undergoing IVF: a systematic review and meta-analysis

Efficacy of granulocyte colony-stimulating factor for infertility undergoing IVF: a systematic review and meta-analysis

Therapeutic role of granulocyte colony-stimulating factor (G-CSF) for infertile women under in vitro fertilization and embryo transfer (IVF-ET) treatment: a meta-analysis

Mediator in the Embryo-endometrium Cross-talk: Granulocyte Colony-stimulating Factor in Infertility

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