Effect of Colloidal Metal Nanoparticles on Biomass, Polysaccharides, Flavonoids, and Melanin Accumulation in Medicinal Mushroom Inonotus obliquus (Ach.:Pers.) Pilát

Poyedinok, Natalia L.; Mykhaylova, Oksana; Sergiichuk, Natalia; Tugay, Tatyana; Tugay, A. V.; Lopatko, Serafym K.; Матвєєва, Н. А.

doi:10.1007/s12010-020-03281-2

Cited by 10 publications

(7 citation statements)

References 35 publications

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“…The renoprotective activities of phenolic meroterpenoids from Ganoderma cochlear were evaluated using rat renal interstitial fibroblast cells ( Wang et al, 2019 ). Additionally, phenolic compounds and flavonoids from chaga also played important roles in antioxidant and hypoglycemic functions ( Duru et al, 2019 ; Poyedinok et al, 2020 ). Further research of purified polysaccharides, active phenols or flavonoids from chaga should be conducted on renal protection separately.…”

Section: Discussionmentioning

confidence: 99%

Renal Protective Effects of Inonotus obliquus on High-Fat Diet/Streptozotocin-Induced Diabetic Kidney Disease Rats: Biochemical, Color Doppler Ultrasound and Histopathological Evidence

et al. 2022

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Diabetic kidney disease (DKD) is the current leading cause of end-stage renal disease. Inonotus obliquus (chaga), a medicinal fungus, has been used in treatment of diabetes. Here, we aim to identify the renal protective effects of chaga extracts on a DKD rat model which was induced by a high-fat diet and streptozotocin injection. During the total 17-weeks experiment, the biological parameters of serum and urine were examined, and the color Doppler ultrasound of renal artery, the periodic acid-Schiff staining, and electron microscopy of kidney tissue were performed. The compositions of chaga extracts were analyzed and the intervention effects of the extracts were also observed. Compared with the normal control group, the biochemical research showed that insulin resistance was developed, blood glucose and total cholesterol were elevated, urinary protein excretion and serum creatinine levels were significantly increased in the DKD model. The ultrasound examinations confirmed the deteriorated blood flow parameters of the left renal interlobar artery in the rat models. Finally, histopathological data supported renal injury on the thickened glomerular basement membrane and fusion of the foot processes. 8 weeks intervention of chaga improved the above changes significantly, and the 100 mg/kg/d chaga group experienced significant effects compared with the 50 mg/kg/d in some parameters. Our findings suggested that Doppler ultrasound examinations guided with biochemical indicators played important roles in evaluating the renal injury as an effective, noninvasive, and repeatable method in rats. Based on biochemical, ultrasound, and histopathological evidence, we confirmed that chaga had pharmacodynamic effects on diabetes-induced kidney injury and the aforementioned effects may be related to delaying the progression of DKD.

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Section: Discussionmentioning

confidence: 99%

Renal Protective Effects of Inonotus obliquus on High-Fat Diet/Streptozotocin-Induced Diabetic Kidney Disease Rats: Biochemical, Color Doppler Ultrasound and Histopathological Evidence

et al. 2022

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“…Various studies have shown that the mushroom-derived silver (Ag-NPs) NPs have dose-dependent toxicity against the different cancer cell lines (MDA-MB, A549, HeLa, K-562) [60]. Fabricated silver Ag-NPs derived from the P. ostreatus extract have also shown an anticancer effect against the HepG2 and MCF-7 adenocarcinoma cancer cell lines [61]. The mechanism of the action NPs induced cytotoxicity towards cancer cells attributes for forming cellular ROS species.…”

Section: Anticancer Propertiesmentioning

confidence: 99%

Mushroom-Derived Nanoparticles in Drug Delivery Systems – Therapeutic Roles and Biological Functions

Pandey,

Ahmad,

Singh

et al. 2023

Precision Nanomedicine

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<img src=” https://s3.amazonaws.com/production.scholastica/article/91083/large/prnano_1042023ga.jpg?1702320855”> In this era of globalization, there is a need for green synthesis of nanoparticles (NPs), which should lessen the tremendous energy consumption, the utilization of toxic compounds, and time, which can help save the environment from hazardous effects. Green synthesis attempts to utilize products from natural agents like plants and fungi because of their profound availability of bio compounds. The NPs derived from them exhibit anticancer, antibacterial, antimicrobial, antioxidant, anti-diabetic, and immunomodulatory properties because of their unique physical and chemical properties. These extraordinary properties make them promising agents in medicine and agriculture areas. The review has targeted the mush-room-derived NPs and bioactive compounds, including the nutritional content of mushrooms with their multipurpose properties, followed by encapsulation and delivery of the biotherapeutics. These NPs have found significant applications in advancing industrial and biomedical ventures. A complete understanding of the synthesis mechanism will help optimize the synthesis protocols and con-trol the shape and size of NPs.

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“…However, not all of the NPs are usually used for medical applications because they could have toxicity [ 138 , 139 , 159 ]. In addition, they can be accumulated on different organisms [ 160 , 161 ] and tissues [ 162 ]. Such is the case of apatite NPs in lipids that surround the site where the NPs was collocated.…”

Section: Nanotechnology Applied To Antimicrobial Resistancementioning

confidence: 99%

Antimicrobial Resistance and Inorganic Nanoparticles

Balderrama-González

Piñón-Castillo

Ramírez-Valdespino

et al. 2021

IJMS

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Antibiotics are being less effective, which leads to high mortality in patients with infections and a high cost for the recovery of health, and the projections that are had for the future are not very encouraging which has led to consider antimicrobial resistance as a global health problem and to be the object of study by researchers. Although resistance to antibiotics occurs naturally, its appearance and spread have been increasing rapidly due to the inappropriate use of antibiotics in recent decades. A bacterium becomes resistant due to the transfer of genes encoding antibiotic resistance. Bacteria constantly mutate; therefore, their defense mechanisms mutate, as well. Nanotechnology plays a key role in antimicrobial resistance due to materials modified at the nanometer scale, allowing large numbers of molecules to assemble to have a dynamic interface. These nanomaterials act as carriers, and their design is mainly focused on introducing the temporal and spatial release of the payload of antibiotics. In addition, they generate new antimicrobial modalities for the bacteria, which are not capable of protecting themselves. So, nanoparticles are an adjunct mechanism to improve drug potency by reducing overall antibiotic exposure. These nanostructures can overcome cell barriers and deliver antibiotics to the cytoplasm to inhibit bacteria. This work aims to give a general vision between the antibiotics, the nanoparticles used as carriers, bacteria resistance, and the possible mechanisms that occur between them.

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Effect of Colloidal Metal Nanoparticles on Biomass, Polysaccharides, Flavonoids, and Melanin Accumulation in Medicinal Mushroom Inonotus obliquus (Ach.:Pers.) Pilát

Cited by 10 publications

References 35 publications

Renal Protective Effects of Inonotus obliquus on High-Fat Diet/Streptozotocin-Induced Diabetic Kidney Disease Rats: Biochemical, Color Doppler Ultrasound and Histopathological Evidence

Renal Protective Effects of Inonotus obliquus on High-Fat Diet/Streptozotocin-Induced Diabetic Kidney Disease Rats: Biochemical, Color Doppler Ultrasound and Histopathological Evidence

Mushroom-Derived Nanoparticles in Drug Delivery Systems – Therapeutic Roles and Biological Functions

Antimicrobial Resistance and Inorganic Nanoparticles

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