Effect of Cognitive Reserve on Age-Related Changes in Cerebrospinal Fluid Biomarkers of Alzheimer Disease

Almeida, Risely Ferraz de; Schultz, Stephanie A.; Austin, Benjamin; Boots, Elizabeth A.; Dowling, N. Maritza; Gleason, Carey E.; Bendlin, Barbara B.; Sager, Mark A.; Hermann, Bruce P.; Zetterberg, Henrik; Carlsson, Cynthia M.; Johnson, Sterling C.; Asthana, Sanjay; Okonkwo, Ozioma C.

doi:10.1001/jamaneurol.2015.0098

Cited by 75 publications

(70 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neural reserve and neural compensation are presumed to underlie the mechanism of CR [44,45]. Recent studies demonstrated CR‐related changes in cerebral blood flow, brain network, neuronal hypertrophy, CSF biomarker of AD, and Aβ pathology assessed by amyloid PET [43,46–48]. Our results indicated that education could also show a preventive effect on the expansion of tau pathology.…”

Section: Discussionmentioning

confidence: 57%

Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3‐PET study

Shimada

Kitamura

Shinotoh

et al. 2016

Alz & Dem Diag Ass & Dis Mo

View full text Add to dashboard Cite

IntroductionAmyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear.MethodsAssociations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(−)-cognitive healthy controls (HCs).ResultsHigh tau burden was associated with aging and low-level education in PiB(−)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(−)-HC.DiscussionThe present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.

show abstract

Section: Discussionmentioning

confidence: 57%

Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3‐PET study

Shimada

Kitamura

Shinotoh

et al. 2016

Alz & Dem Diag Ass & Dis Mo

View full text Add to dashboard Cite

show abstract

“…The longitudinal study of Krell‐Roesch et al corroborates this hypothesis finding that subjects involved in mentally stimulating activities even in late life had a lower risk of developing mild cognitive impairment (Krell‐Roesch et al, ). Although the mechanisms underlying this association remain still unclear, some authors observed that cognitively demanding activities were linked to diminished or slower deposition of β‐amyloid in the cortex (Marks et al, ), reduced rate of hippocampal atrophy (Valenzuela et al, ), and decreased age‐related alterations in cerebrospinal biomarkers of Alzheimer's disease (Almeida et al, ). The protective effect of an active lifestyle and involvement in mentally stimulating activities on cognitive function, furthermore, could be influenced by factors such as socioeconomic and educational levels (Aartsen et al, ) which we considered, in fact, as covariates.…”

Section: Discussionmentioning

confidence: 99%

The effect of childcare activities on cognitive status and depression in older adults: gender differences in a 4.4‐year longitudinal study

Trevisan

Pamio

Curreri

et al. 2017

Int J Geriat Psychiatry

View full text Add to dashboard Cite

show abstract

“…CSF was collected as described previously [40, 41]. CSF Aβ 42 and phosphorylated-tau (p-tau) were quantified with sandwich ELISAs (INNOTEST β-amyloid1–42 and Phospho-Tau[181P], respectively; Fujirebio Europe, Ghent, Belgium).…”

Section: Methodsmentioning

confidence: 99%

Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer’s Disease

Racine

Clark

Berman

et al. 2016

JAD

Self Cite

View full text Add to dashboard Cite

It is not known whether computerized cognitive assessments, like the CogState battery, are sensitive to preclinical cognitive changes or pathology in people at risk for Alzheimer’s disease (AD). In 469 late middle-aged participants from the Wisconsin Registry for Alzheimer’s Prevention (mean age 63.8±7 years at testing; 67% female; 39% APOE4+), we examined relationships between a CogState abbreviated battery (CAB) of seven tests and demographic characteristics, traditional paper-based neuropsychological tests as well as a composite cognitive impairment index, cognitive impairment status (determined by consensus review); and biomarkers for amyloid and tau (CSF phosphorylated-tau/Aβ42 and global PET-PiB burden) and neural injury (CSF neurofilament light protein). CSF and PET-PiB were collected in n=71 and n=91 participants, respectively, approximately four years prior to CAB testing. For comparison, we examined three traditional tests of delayed memory in parallel. Similar to studies in older samples, the CAB was less influenced by demographic factors than traditional tests. CAB tests were generally correlated with most paper-based cognitive tests examined and mapped onto the same cognitive domains. Greater composite cognitive impairment index was associated with worse performance on all CAB tests. Cognitively impaired participants performed significantly worse compared to normal controls on all but one CAB test. Poorer One Card Learning test performance was associated with higher levels of CSF phosphorylated-tau/Aβ42. These results support the use of the CogState battery as measures of early cognitive impairment in studies of people at risk for AD.

show abstract

Effect of Cognitive Reserve on Age-Related Changes in Cerebrospinal Fluid Biomarkers of Alzheimer Disease

Cited by 75 publications

References 43 publications

Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3‐PET study

Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3‐PET study

The effect of childcare activities on cognitive status and depression in older adults: gender differences in a 4.4‐year longitudinal study

Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer’s Disease

Contact Info

Product

Resources

About

Effect of Cognitive Reserve on Age-Related Changes in Cerebrospinal Fluid Biomarkers of Alzheimer Disease

Cited by 75 publications

References 43 publications

Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [11C]PBB3‐PET study

Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [11C]PBB3‐PET study

The effect of childcare activities on cognitive status and depression in older adults: gender differences in a 4.4‐year longitudinal study

Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer’s Disease

Contact Info

Product

Resources

About

Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3‐PET study

Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [¹¹C]PBB3‐PET study