Effect of Coffee Consumption on Intraocular Pressure

Avisar, Rahamim; Avisar, Erez; Weinberger, Dov

doi:10.1345/aph.1a279

Cited by 89 publications

(75 citation statements)

References 13 publications

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“…Several studies found IOP changes to be negligible, [25][26][27][28][29][30] whereas others report increases of approximately 1-4 mm Hg. [31][32][33][34][35][36] A recent meta-analysis 37 called for more high-quality randomized clinical trials (RCTs) to better assess caffeine's effects on IOP in those with or at risk for glaucoma and in older subjects. Most RCTs investigating caffeine intake and IOP have examined healthy subjects 25,28,29,33,34 with a mean age of 25 years.…”

Section: Introductionmentioning

confidence: 99%

“…Most RCTs investigating caffeine intake and IOP have examined healthy subjects 25,28,29,33,34 with a mean age of 25 years. 37 Only two RCTs 31,32 have enrolled glaucoma and glaucoma suspect patients, and neither disclosed the subjects' ages. Furthermore, neither trial 31,32 was participant-masked, and one study 31 was not investigator-masked.…”

Section: Introductionmentioning

confidence: 99%

“…37 Only two RCTs 31,32 have enrolled glaucoma and glaucoma suspect patients, and neither disclosed the subjects' ages. Furthermore, neither trial 31,32 was participant-masked, and one study 31 was not investigator-masked.…”

Section: Introductionmentioning

confidence: 99%

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Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial

Jiwani

Rhee

Brauner

et al. 2012

Eye

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Purpose To examine the effects of caffeinated coffee consumption on intraocular pressure (IOP), ocular perfusion pressure (OPP), and ocular pulse amplitude (OPA) in those with or at risk for primary open-angle glaucoma (POAG). Methods We conducted a prospective, double-masked, crossover, randomized controlled trial with 106 subjects: 22 with high tension POAG, 18 with normal tension POAG, 20 with ocular hypertension, 21 POAG suspects, and 25 healthy participants. Subjects ingested either 237 ml of caffeinated (182 mg caffeine) or decaffeinated (4 mg caffeine) coffee for the first visit and the alternate beverage for the second visit. Blood pressure (BP) and pascal dynamic contour tonometer measurements of IOP, OPA, and heart rate were measured before and at 60 and 90 min after coffee ingestion per visit. OPP was calculated from BP and IOP measurements. Results were analysed using paired t-tests. Multivariable models assessed determinants of IOP, OPP, and OPA changes. Results There were no significant differences in baseline IOP, OPP, and OPA between the caffeinated and decaffeinated visits. After caffeinated as compared with decaffeinated coffee ingestion, mean mm Hg changes ( ± SD) in IOP, OPP, and OPA were as follows: 0.99 ( ± 1.52, Po0.0001), 1.57 ( ± 6.40, P ¼ 0.0129), and 0.23 ( ± 0.52, Po0.0001) at 60 min, respectively; and 1.06 (±1.67, Po0.0001), 1.26 (±6.23, P ¼ 0.0398), and 0.18 (±0.52, P ¼ 0.0006) at 90 min, respectively. Regression analyses revealed sporadic and inconsistent associations with IOP, OPP, and OPA changes. Conclusion Consuming one cup of caffeinated coffee (182 mg caffeine) statistically increases, but likely does not clinically impact, IOP and OPP in those with or at risk for POAG.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial

Jiwani

Rhee

Brauner

et al. 2012

Eye

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“…Among documented clinical effects of caffeine are increased heart rate, systolic blood pressure and left ventricular output [7,8,11] stimulation of autonomic responses [12,13] decreased tone of the gastrointestinal smooth muscles increased ocular pressure in glaucoma patients [14] central nervous system excitation and increased alertness [2,5,9] However, the only study we were able to find documenting the response of salivation to ingestion of any methylxanthine was a retrospective analysis of Pavlovian date [15]. Nevertheless, in the dental community, the belief that caffeine consumption decreases salivary production is widely held [6].…”

Section: Discussionmentioning

confidence: 99%

Effects of Caffeine on Salivation

Barasch¹,

Gordon²

2016

Oral Health Case Reports

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“…Since contact lens wear can affect the corneal surface, thickness and curvature (Liu & Pflugfelder, 2000), contact lens wearing subjects (n = 2) were instructed to discontinue contact lens use on the day of measurement. Caffeine intake has been shown to increase IOP (Avisar et al, 2002) and alcohol consumption has been shown to lower IOP (Houle & Grant, 1967). Since IOP can influence axial length measurements, all participants were instructed to avoid caffeine and alcohol from the evening before and on the measurement day.…”

Section: Daily Ocular Variation Measurements: 522mentioning

confidence: 99%

The Influence of Light Exposure and Seasonal Changes on Short-Term and Longer-Term Changes in Axial Length of the Human Eye

Ulaganathan¹

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It is widely accepted that environmental factors play a significant role in regulating eye growth and myopia development. There is also considerable evidence that ambient light exposure is an important environmental risk factor associated with eye growth in children, however, the underlying mechanism remains unclear. Furthermore, animal studies have shown that diurnal variations in ocular components appear to be involved in the mechanisms controlling eye growth. Animal studies also suggest that altering light exposure disrupts normal diurnal variations and can lead to the development of refractive errors. Despite this evidence, the exact role of light exposure and ocular diurnal rhythms in the regulation of human eye growth, and the interaction between these factors is not well understood. Myopia development and progression have been widely documented in young adults and typically occurs due to axial elongation, but there has been limited research examining the potential impact of ambient light exposure upon eye growth and myopia development and progression in young adults.Therefore, this research examined the habitual light exposure patterns in a population of young adult emmetropes and progressing myopes using objective techniques, and assessed the influence of light exposure upon daily axial length variations and longitudinal axial eye growth in this population. The potential association between daily axial length fluctuations and longer-term changes in axial length was also explored.Since there is no consensus on the optimal sampling strategy required for capturing personal objective light exposure measurements, in the first study, we systematically examined the impact of different measurement durations and measurement frequencies upon objective light exposure measures, in order to determine the optimal sampling strategy to reliably capture habitual light exposure patterns of both children (Age: 11 to vi The influence of light exposure and seasons upon the axial length changes in humans 15 years) and young adults (Age: 18 to 30 years). Ambient light exposure data were obtained using a wrist-worn light sensor (Actiwatch 2), which was configured to measure instantaneous light levels every 30 seconds, 24 hours a day for a period of 14 consecutive days in children (n = 30) and young adults (n = 31). Daily time exposed to bright outdoor (>1000 lux) light levels was derived from the raw 14 days of data with 30 second sampling, and was subsequently derived from data re-sampled from 12, 10, 8, 6, 4 and 2 randomly selected measurement days using 1, 2, 3, 4, 5 and 10 minute sampling rates. Calculating daily outdoor light exposure time using a lower number of days and coarser sampling frequencies did not significantly alter the mean time spent in bright (outdoor) light. However, a significant increase in measurement variability occurred for outdoor light exposure derived from less than 8 days and from 3 minutes or coarser measurement frequencies in adults, and from less than 8 days and from 4 minutes or coarser...

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Effect of Coffee Consumption on Intraocular Pressure

Abstract: Intake of caffeinated beverage (>/=180 mg caffeine) may not be recommended for patients with normotensive glaucoma or ocular hypertension.

Cited by 89 publications

References 13 publications

Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial

Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial

Effects of Caffeine on Salivation

The Influence of Light Exposure and Seasonal Changes on Short-Term and Longer-Term Changes in Axial Length of the Human Eye

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