Effect of Coenzyme Q7 Treatment on Blood Sugar and Ketone Bodies of Diabetics

Shigeta, Yukio; Izumi, Kanji; Abe, Hiroshi

doi:10.5925/jnsv1954.12.293

Cited by 12 publications

(13 citation statements)

References 2 publications

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“…Since 1966, ubiquinone supplementation has been investigated as a clinical application for diabetes patients. Shigeta et al (29) was the first researcher to use ubiquinone (120 mg/d) for diabetes patients and found that 67 % of diabetes patients exhibited significantly decreased glucose levels after supplementation. Hodgson et al (20) and Kolahdouz Mohammadi et al (30) used dosage of ubiquinone supplementation (200 mg/d) in patients with type 2 diabetes, and the results showed a significant lowering effect on HbA1c after 12 weeks of supplementation.…”

Section: Discussionmentioning

confidence: 99%

“…Hodgson et al (20) and Kolahdouz Mohammadi et al (30) used dosage of ubiquinone supplementation (200 mg/d) in patients with type 2 diabetes, and the results showed a significant lowering effect on HbA1c after 12 weeks of supplementation. On the basis of these findings (20,29,30) , we hypothesised that ubiquinone supplementation at a dose of 200 mg/d might benefit glucose control in diabetes. Because ubiquinone is a lipid and an oxidised form of coenzyme Q10, it should be transformed into ubiquinol to participate in human metabolism; therefore, a liquid ubiquinol supplement was recently developed.…”

Section: Discussionmentioning

confidence: 99%

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Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial

et al. 2018

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Ubiquinone is a lipid antioxidant, and a novel liquid ubiquinol (a hydro-soluble, reduced form of coenzyme Q10) supplement was recently developed. The purpose of this study was to examine the levels of glucose, lipids and antioxidant capacity of type 2 diabetes patients after liquid ubiquinol supplementation. This study was designed as a randomised, double-blind, placebo-controlled trial. In all, fifty participants were randomly assigned to a placebo (n 25) or liquid ubiquinol (100 mg/d, n 25) group, and the intervention lasted for 12 weeks. Plasma coenzyme Q10, glucose homoeostasis parameters, lipid profiles, oxidative stress and antioxidative enzyme activities were measured during the study. After 12 weeks of supplementation, glyco Hb (HbA1c) value was significantly decreased in the liquid ubiquinol group (P=0·03), and subjects in the liquid ubiquinol group had significantly lower anti-glycaemic medication effect scores (MES) compared with those in the placebo group (P=0·03). The catalase (P<0·01) and glutathione peroxidase (P=0·03) activities were increased significantly after supplementation. Plasma coenzyme Q10 was correlated with the insulin level (P=0·05), homoeostatic model assessment-insulin resistance (P=0·07), quantitative insulin sensitivity check index (P=0·03) and the anti-hyperglycaemic agents' MES (P=0·03) after supplementation. Lipid profiles did not change after supplementation; however, the subjects in the placebo group had a significantly lower level of HDL-cholesterol after 12 weeks of intervention. In conclusion, oral intake of 100 mg/d liquid ubiquinol might benefit type 2 diabetes patients by increasing antioxidant enzyme activity levels, reducing HbA1c levels and maintaining HDL-cholesterol levels.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial

et al. 2018

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“…This effect might particularly extend to triglyceride-rich lipoproteins in the post-prandial phase, when oxidative stress could be maximal in diabetes [39]. Coenzyme Q 10 supplementation has been reported to improve glycaemic control [14,18,21,22] and blood pressure [22] in patients with diabetes. However, along with other studies [40,41], we found no evidence to support this finding.…”

Section: Discussionmentioning

confidence: 99%

“…Low serum CoQ concentrations have been negatively correlated with poor glycaemic control and diabetic complications [19,20]. Accordingly, some clinical trials have shown that CoQ could improve glycaemic control and blood pressure in diabetes [14,18,21,22]. Hence, CoQ could have a potential role in the treatment of diabetes and its complications [14,18,23].…”

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confidence: 99%

Coenzyme Q10 improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus

et al. 2002

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In Type II (non-insulin-dependent) diabetes mellitus the pathogenesis of vascular disease, its most common complication, remains unclear [1]. Endothelial dysfunction reflects the disordered physiology of several endothelium-derived vasoactive factors, in particular nitric oxide [2]. Endothelial dysfunction occurs commonly in diabetes and is an early feature of vasculopathy [3,4]. Increased oxidative stress due to the effects of hyperglycaemia and its sequelae is a recognized feature of diabetes [5]. It might cause endothelial dysfunction through the inactivation and Abstract Aim/hypothesis. We assessed whether dietary supplementation with coenzyme Q 10 improves endothelial function of the brachial artery in patients with Type II (non-insulin-dependent) diabetes mellitus and dyslipidaemia. Methods. A total of 40 patients with Type II diabetes and dyslipidaemia were randomized to receive 200 mg of coenzyme Q 10 or placebo orally for 12 weeks. Endothelium-dependent and independent function of the brachial artery was measured as flowmediated dilatation and glyceryl-trinitrate-mediated dilatation, respectively. A computerized system was used to quantitate vessel diameter changes before and after intervention. Arterial function was compared with 18 non-diabetic subjects. Oxidative stress was assessed by measuring plasma F 2 -isoprostane concentrations, and plasma antioxidant status by oxygen radical absorbance capacity. Results. The diabetic patients had impaired flow-mediated dilation [3.8 % (SEM 0.5) vs 6.4 % (SEM 1.0), p = 0.016], but preserved glyceryl-trinitrate-mediated dilation, of the brachial artery compared with non-diabetic subjects. Flow-mediated dilation of the brachial artery increased by 1.6 % (SEM 0.3) with coenzyme Q 10 and decreased by ±0.4 % (SEM 0.5) with placebo (p = 0.005); there were no group differences in the changes in pre-stimulatory arterial diameter, post-ischaemic hyperaemia or glyceryl-trinitrate-mediated dilation response. Coenzyme Q 10 treatment resulted in a threefold increase in plasma coenzyme Q 10 (p < 0.001) but did not alter plasma F 2 -isoprostanes, oxygen radical absorbance capacity, lipid concentrations, glycaemic control or blood pressure. Conclusion/interpretation. Coenzyme Q 10 supplementation improves endothelial function of conduit arteries of the peripheral circulation in dyslipidaemic patients with Type II diabetes. The mechanism could involve increased endothelial release and/or activity of nitric oxide due to improvement in vascular oxidative stress, an effect that might not be reflected by changes in plasma F 2 -isoprostane concentrations. [Diabetologia (2002) 45: 420±426]

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“…Shigeta et al [34], Zahedi et al [35], Singh et al [36] observed that CoQ 10 supplementation in patients with T2DM significantly reduces serum levels of FBS. These findings were confirmed in the current study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Coenzyme Q10 Supplementation on Serum Values of Gamma-glutamyl transferase, Pseudocholinesterase, Bilirubin, Ferritin, and High-Sensitivity C-Reactive Protein in Women with Type 2 Diabetes

Gholami

Rezvanfar

Delavar

et al. 2018

Exp Clin Endocrinol Diabetes

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Effect of Coenzyme Q7 Treatment on Blood Sugar and Ketone Bodies of Diabetics

Cited by 12 publications

References 2 publications

Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial

Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial

Coenzyme Q10 improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus

Effects of Coenzyme Q10 Supplementation on Serum Values of Gamma-glutamyl transferase, Pseudocholinesterase, Bilirubin, Ferritin, and High-Sensitivity C-Reactive Protein in Women with Type 2 Diabetes

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