Effect of Coenzyme Q10 Supplementation on Statin-Induced Myalgias

Bookstaver, David A.; Burkhalter, Nancy A.; Hatzigeorgiou, Christos

doi:10.1016/j.amjcard.2012.04.026

Cited by 75 publications

(60 citation statements)

References 21 publications

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“…No correlation between Q10 supplementation and change in myalgia score [18] or creatine kinase (CK) values [17] were found in these two studies. In a third study, 76 patients on statin therapy who had developed new onset myalgia were randomized to 120 mg Q10 daily or placebo for 3 months in combination with continued statin therapy [16]. No protective effect of Q10 supplementation could be demonstrated in this study either.…”

Section: Discussionmentioning

confidence: 99%

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Statin‐induced Myopathy and Ubiquinone Levels in Serum – Results from a Prospective, Observational Study

Skilving

Ačimovič

Rane

et al. 2015

Basic Clin Pharma Tox

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It has been suggested that an impaired ubiquinone (Q10) synthesis may be responsible for muscular side effects caused by statins. The primary aim of this study was to investigate whether low Q10 levels in serum could be used as a marker to predict the risk of developing statin-induced myopathy. The secondary aim was to compare the change in Q10 levels during statin treatment and differences between men and women. Serum samples from a prospective, observational study in statin-treated patients who were thoroughly followed regarding muscular symptoms were used. In this cohort, 16 developed myopathy and 126 had no muscular symptoms related to statin treatment. Q10 levels were measured with a novel LC-MS method at baseline and after 2 months of statin treatment. Q10 levels showed no correlation with the risk of developing statin-induced myopathy. Individuals with low levels, Q10 < 200 ng/ml, at baseline had no increased risk of developing myopathy. In consistence with earlier reports, we showed that Q10 levels were reduced by 30% during statin treatment. There was no significant difference in the reduction between patients with or without myopathy. Women had approximately 30% lower Q10 levels compared to men both before and after treatment. In this study, there was no association between Q10 levels at baseline and statin-induced muscular side effects during a 2-month follow-up period, and our results indicate that Q10 levels in serum is not a useful marker to predict statin-induced myopathy.Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are used for treatment of hypercholesterolaemia and have a pronounced, preventive effect on serious cardiovascular events and mortality [1,2]. Today, statins are some of the most prescribed drugs in the Western world, and the consumption is steadily increasing [3]. However, several reports have demonstrated that statin-induced muscular side effects such as myalgia are more common than first demonstrated in clinical trials. In fact, 10-15% of patients prescribed statins may experience muscle symptoms [4][5][6]. The statin-induced myopathy is considered to be dose dependent [7] but independent of the cholesterol-lowering effect [8].Statins affect not only the synthesis of cholesterol but also all products in the cholesterol biosynthesis pathway.Ubiquinone (Q10) is one of these products. The major part of the intracellular Q10 is present in the inner mitochondrial membrane as an essential part of the electron transport chain [9,10]. A smaller fraction is present in the cytosol where it has antioxidative functions [9,11]. Q10 is also present in the blood and is mainly bound to low-density lipoprotein (LDL) and also, to some extent, to high density lipoprotein (HDL) and very low-density lipoprotein (VLDL) [12].It has been suggested that the decreased synthesis of Q10 may be involved in statin-induced myopathy [13,14]. In particular, the reduction of mitochondrial Q10 has been suggested to cause myopathy, and statin treatments have been shown to negatively a...

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Section: Discussionmentioning

confidence: 99%

“…The hypothesis that decreased levels of Q10 during statin treatment might cause adverse events has been investigated, but results have been inconclusive [16][17][18].…”

mentioning

confidence: 99%

Statin‐induced Myopathy and Ubiquinone Levels in Serum – Results from a Prospective, Observational Study

Skilving

Ačimovič

Rane

et al. 2015

Basic Clin Pharma Tox

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“…42 However, a recent randomized study demonstrated that in such cases, administration of CoQ10 60 mg twice daily for 3 months, was ineffective and not better than placebo. 43 Considering the safety of CoQ10, it appears to be quite safe even in daily doses of 2400 mg, with the exception of mild gastrointestinal upset. 44 Multivitamins Multivitamins are the most widely used food supplements throughout the world, and there has been a growing interest in the potential role of multivitamins in reducing the risk of chronic diseases including CVD, HTN, cancer and brain dysfunction.…”

Section: Dietary Supplementsmentioning

confidence: 98%

The clinical significance and costs of herbs and food supplements used by complementary and alternative medicine for the treatment of cardiovascular diseases and hypertension

Chrysant

2015

J Hum Hypertens

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Complementary and alternative medicine (CAM) is widely used by people in the United States and other countries for the treatment of health conditions that include hypertension (HTN), cardiovascular disease (CVD), heart failure, hyperlipidemia and other condtions. The visits to CAM practitioners result in significant out-of-pocket expenses, as CAM is not covered by health insurance in the majority of cases. The reasons for this are that the products used are not closely regulated by governmental regulatory agencies and lack scientific evidence about their effectiveness and safety. The people regard these products as being 'natural' and, consequently, safe. However, there is evidence that these products can be contaminated and adulterated with other substances and could cause harm to the persons who take them. The responsibility falls on the health professionals, who should become familiar with the various CAM products, inquire their patients whether they taking any of these products and advise them accordingly. This review is based on a recent statement issued by the American Medical for the use of CAM for the treatment of HTN. For its preparation, a Medline search of the English language literature was performed between 2010 and 2014 restricted in the use of CAM for CVD and HTN, and from the 88 abstracts reviewed, 23 pertinent papers were selected. These papers together with collateral literature will be discussed in this review regarding CAM and CAM products on their effectiveness and safety for the treatment of CVD and HTN.

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“…The review's authors concluded that the evidence is insuffi cient to prove that CoQ10 defi ciency has a causal role in statin-associated myopathy and that more large, well-designed clinical trials were required to address this issue. In another study, 76 patients with myalgias presumed to be caused by statins were randomly assigned to therapy with 120 mg CoQ10 a day or placebo while continuing statin therapy [ 233 ]. CoQ10 did not reduce patient-reported pain to a greater extent than placebo.…”

Section: Coq10: Cardiovascular Healthmentioning

confidence: 99%

Dietary Supplements in Older Adults

Dwyer

Costello

Merkel

et al. 2014

Handbook of Clinical Nutrition and Aging

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IntroductionThis chapter focuses on the rationale and evidence base for the use of dietary supplements for both maintaining health and decreasing the risks of some common chronic diseases. This review also updates the information in a review of data through 2009 on nutritional supplements for older adults [ 1 ] by summarizing evidence published in 2009-2013 from systematic reviews and meta-analyses of randomized clinical trials with disease endpoints. The chapter concludes with recommendations for assessing dietary supplement use in older persons and suggestions for counseling them. We have categorized these supplements according to their active ingredient(s), and we pay particular attention to

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Effect of Coenzyme Q10 Supplementation on Statin-Induced Myalgias

Cited by 75 publications

References 21 publications

Statin‐induced Myopathy and Ubiquinone Levels in Serum – Results from a Prospective, Observational Study

Statin‐induced Myopathy and Ubiquinone Levels in Serum – Results from a Prospective, Observational Study

The clinical significance and costs of herbs and food supplements used by complementary and alternative medicine for the treatment of cardiovascular diseases and hypertension

Dietary Supplements in Older Adults

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