Effect of coenzyme Q10 on cardiac function and survival in heart failure: an overview of systematic reviews and <i>meta</i>-analyses

Alarcón-Vieco, Eva; Martínez-García, Irene; Sequí-Domínguez, Irene; Rodríguez-Gutiérrez, Eva; Moreno-Herráiz, Nerea; Pascual-Morena, Carlos

doi:10.1039/d3fo01255g

Cited by 7 publications

(4 citation statements)

References 55 publications

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“…CoQ10 benefits cardiovascular health as it can help reduce total cholesterol, improve endothelial function, and fight inflammation and oxidative stress. This also makes it a suitable option for treating COVID-19 [106][107][108][109][110]. A recent meta-analysis found that CoQ10 supplements taken for 10 weeks or less at doses above 200 mg/day may lower malondialdehyde (MDA), TNF-α, and IL-6 levels.…”

Section: Coenzyme Q10 (Coq10)mentioning

confidence: 99%

Plant-Based Diet and Supplements Reduced COVID-19 Severity and Mortality in Elderly Patients with Multiple Comorbidities (Part 2: Exploring the Underlying Mechanisms of Successful Intervention)

Mulijono,

Hutapea,

Lister

et al. 2024

Preprint

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The potential advantages of plant-based interventions in decreasing the incidence and lessening the severity and mortality of COVID-19 are yet to be widely acknowledged. Nevertheless, recent investigations propose that these interventions could be effective. Our recent publication (part one) features an interventional study in which we incorporated plant-based foods and provided supplementation to 3470 elderly COVID-19 patients with multiple comorbidities. We pay close attention to the precise selection of food items, the application of appropriate processing methods, and the provision of nourishing meals to our patients. Our outcome was highly successful as we achieved a zero mortality rate, and none of our patients experienced worsening conditions or required hospitalization. This second paper presents our theoretical framework on the mechanisms through which plant-based and supplement interventions can mitigate disease severity and mortality. However, only very recently have experts validated our hypotheses. The measures and methods used to address the ongoing SARS-CoV-2 pandemic through plant-based interventions and supplements are effective and may help prevent or manage future pandemics.

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Section: Coenzyme Q10 (Coq10)mentioning

confidence: 99%

Plant-Based Diet and Supplements Reduced COVID-19 Severity and Mortality in Elderly Patients with Multiple Comorbidities (Part 2: Exploring the Underlying Mechanisms of Successful Intervention)

Mulijono,

Hutapea,

Lister

et al. 2024

Preprint

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“…Therefore, for accurate contour tracking of the left ventricle, especially in high-resolution images, it is necessary to appropriately adjust the traditional GAC model to ensure that the contours can accurately capture the dynamic boundaries of the left ventricle. Assuming the gradient characteristic function on image 2 , represented by h. The main force dragging the contour to the target edge in the GAC model is represented by the term hθ, and the reconstructed GAC level set iteration equation is given by: hh s…”

Section: Lower Layer Image Processingmentioning

confidence: 99%

“…In contemporary medical diagnostics, precise assessment of cardiac function is crucial for the treatment and management of patients with heart failure. Heart failure is a severe clinical condition involving a decline in cardiac pumping capability, affecting systemic blood circulation [1][2][3]. Dynamic cardiac ultrasound imaging, a non-invasive and cost-effective diagnostic method, can visually display the cardiac motion state and is valuable for assessing left ventricular function [4,5].…”

Section: Introductionmentioning

confidence: 99%

Advanced Techniques in Dynamic Cardiac Ultrasound Imaging for Assessing Left Ventricular Function in Heart Failure Patients

Chen,

Li,

Zhu

et al. 2024

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Heart failure, a condition characterized by a decline in cardiac pumping capacity, necessitates precise assessment of cardiac function due to its systemic impact on blood circulation. Dynamic cardiac ultrasound imaging serves as a crucial tool for evaluating left ventricular function. The quality of these images directly influences the accuracy of diagnostics and the effectiveness of treatments. Existing cardiac ultrasound image processing technologies face limitations in enhancing details, noise reduction, and capturing dynamic information. This study introduces a novel image processing technique that integrates visual attention mechanisms and generative adversarial networks (GAN) to enhance the details of dynamic cardiac ultrasound images. Additionally, it employs an algorithm based on dynamic contour models for image segmentation and assessment of left ventricular function. The application of these techniques aims to improve the processing quality of cardiac ultrasound images, enabling more accurate assessments of left ventricular function and providing more effective support for the diagnosis and treatment of heart failure patients.

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“…It is critical for cellular functions ( Hargreaves et al, 2020 ), particularly in energy production through adenosine triphosphate synthesis ( Aussel et al, 2014 ), acting as an antioxidant to combat free radicals ( Bentinger et al, 2007 ), and inhibiting lipid peroxidation to protect cell membranes from oxidative damage ( Zhang et al, 2013 ). Clinically, CoQ10 is utilized in the management of heart failure and myocarditis, owing to its ability to preserve the morphology and structure of mitochondria in ischemic cardiomyocytes ( Alarcón-Vieco et al, 2023 ). Moreover, it is also used in the treatment of antioxidants ( Samimi et al, 2024 ) and maintenance of muscle function ( Talebi et al, 2024 ).…”

Section: Impact Of Nutrients On the Ocular Surface And Potential Risksmentioning

confidence: 99%

Recommendations for nutritional supplements for dry eye disease: current advances

Cong,

Zhang,

Han

et al. 2024

Front. Pharmacol.

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Dry eye disease (DED) represents a prevalent ocular surface disease. The development of effective nutritional management strategies for DED is crucial due to its association with various factors such as inflammation, oxidative stress, deficiencies in polyunsaturated fatty acids (PUFAs), imbalanced PUFA ratios, and vitamin insufficiencies. Extensive research has explored the impact of oral nutritional supplements, varying in composition and dosage, on the symptoms of DED. The main components of these supplements include fish oils (Omega-3 fatty acids), vitamins, trace elements, and phytochemical extracts. Beyond these well-known nutrients, it is necessary to explore whether novel nutrients might contribute to more effective DED management. This review provides a comprehensive update on the therapeutic potential of nutrients and presents new perspectives for combination supplements in DED treatment.

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Effect of coenzyme Q10 on cardiac function and survival in heart failure: an overview of systematic reviews and meta-analyses

Abstract: Heart failure (HF) is associated with a deficiency in blood levels of coenzyme Q10 (CoQ10), and its supplementation has been proposed. The aim of this systematic review was to synthesise...

Cited by 7 publications

References 55 publications

Plant-Based Diet and Supplements Reduced COVID-19 Severity and Mortality in Elderly Patients with Multiple Comorbidities (Part 2: Exploring the Underlying Mechanisms of Successful Intervention)

Plant-Based Diet and Supplements Reduced COVID-19 Severity and Mortality in Elderly Patients with Multiple Comorbidities (Part 2: Exploring the Underlying Mechanisms of Successful Intervention)

Advanced Techniques in Dynamic Cardiac Ultrasound Imaging for Assessing Left Ventricular Function in Heart Failure Patients

Recommendations for nutritional supplements for dry eye disease: current advances

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