Effect of coenzyme Q10 andArdisia japonicaBlume on plasma and liver lipids, platelet aggregation, and erythrocyte Na efflux channels in simvastatin-treated guinea pigs

Abstract

Forty guinea pigs were divided into four groups and fed 0.04% cholesterol based control diet, plus 0.05% simvastatin, and statin plus 0.1% CoQ10 or 10% Ardisia Japonica Blume (AJB) leave powder for 4 weeks. Plasma total cholesterol levels decreased significantly in all groups fed the statin-containing diet compared with that in guinea pigs fed the control diet (P < 0.01). Plasma and liver triglycerides decreased significantly in the statin plus CoQ10 group compared with those in the control (both P < 0.05). Maximum platelet aggregation was significantly higher in the statin plus CoQ10 group than that in the other groups (P < 0.05). Na-K ATPase activity increased in the statin group and decreased in the statin plus CoQ10 group (P < 0.01). Na-K co-transport and Na passive transport decreased significantly in the control group compared with those in the other groups (both P < 0.05). Intracellular Na was highest in the statin group and lowest in the statin plus CoQ10 group and was correlated with Na-K ATPase activity. Thiobarbituric acid reactive substance production in platelet-rich plasma and liver tended to decrease in the statin plus CoQ10 group compared with those in the other groups. Plasma glutamic-pyruvic transaminase and glutamic-oxaloacetic transaminase increased significantly in the statin group compared with those in the control (P < 0.05). These result suggest that antioxidant rich AJB did not have positive effects on cardiovascular disease parameters. The statin plus CoQ10 seemed to decrease cholesterol more efficiently than that of statin alone.

Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet

“…Our study showed a significant decrease of cholesterol and triacylglycerol levels in the liver of animals treated with ATV and CoQ 10 , compared with those rats that only received ATV. These results are in coincidence with other reports [ 11 ] that suggest CoQ 10 improves the hypolipemiant action of statins. As we already mentioned it is not currently known the mechanism by which CoQ 10 increases statins action.…”

“…These results support a better hypolipidemic effect of ATV in the presence of CoQ 10 . This improvement in the effect of ATV by CoQ 10 has already been reported in Guinea pigs [10,11]. …”

Protective Potential of Ginseng and/or Coenzyme Q10 on Doxorubicin-induced Testicular and Hepatic Toxicity in Rats

“…Treatment with CoQ10 revealed a significant decrease in serum cholesterol and TG when compared with the DOX group and a significant increase when compared with DOX/Gin group. The improvement in the hypolipidemic effect of atorvastatin by CoQ10 has already been reported in Guinea pigs [43].…”

Qualitative, quantitative, and pharmacokinetic study on the absorbed components of Ardisia japonica (Thunb.) Blume in rat plasma based on molecular networking combined with quadrupole time‐of‐flight LC/MS and triple quadrupole LC/MS

“…Blume (A. japonica) was selected as the experimental plant. A. japonica, which belongs to the Myrsinaceae family, is widely distributed in South China (Kang et al, 2012). Since its first recording in an ancient Chinese encyclopedia called Compendium of Materia Medica (Bencao Gangmu), A. japonica has been used in China for thousands of years.…”