Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study

Tiano, Luca; Belardinelli, Romualdo; Carnevali, Paola; Principi, Federica; Seddaiu, Giovanna; Littarru, Gian Paolo

doi:10.1093/eurheartj/ehm267

Cited by 131 publications

(83 citation statements)

References 29 publications

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“…In a randomized, double-blind, crossover study, CoQ 10 supplementation significantly improved brachial artery FMD in statin-treated T2D patients with LDLcholesterol <2.5mmol/l and ED [234]. In patients with CAD (20% with diabetes and 80% statin-treated), CoQ 10 supplementation improved ecSOD levels and brachial artery FMD, indicating that the beneficial effects of CoQ 10 on endothelial function are in part related to improvements in local vascular oxidative stress [235]. -Fibrates and antioxidants.…”

Section: Combination Therapiesmentioning

confidence: 95%

“…Abbreviations: FMD -flow-mediated dilation of the brachial artery, ACh -acetylchollilne, FABF -forearm blood flow, ns -no significant effect, SNP -sodium nitroprusside, BK -bradykinin, L-NMMA -L-nitro-mono-methyl arginine, EPA -eicosapentenoic acid, DHA -docosahexenoic acid, T2D -type 2 diabetes mellitus, AIx -augmentation index, IMT -intima-media thickness, MRI -magnetic resonance imaging, MUFA -monounsaturated fatty acids, omega-3 FA -omega-3 fatty acids, CoQ 10 -coenzyme Q 10 , VCAM-I -vascular cell adhesion molecules 1, RH -reactive hyperemia. References [109,139,143,209,220,221,226,235,241].…”

Section: Lipid-regulating Therapymentioning

confidence: 99%

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Endothelial Dysfunction in Diabetes: Pathogenesis, Significance, and Treatment

2013

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■ AbstractType 2 diabetes (T2D) markedly increases the risk of cardiovascular disease. Endothelial dysfunction (ED), an early indicator of diabetic vascular disease, is common in T2D and independently predicts cardiovascular risk. Although the precise pathogenic mechanisms for ED in T2D remain unclear, at inception they probably involve uncoupling of both endothelial nitric oxide synthase activity and mitochondrial oxidative phosphorylation, as well as the activation of vascular nicotinamide adenine dinucleotide phosphate oxidase. The major contributing factors include dyslipoproteinemia, oxidative stress, and inflammation. Therapeutic interventions are designed to target these pathophysiological factors that underlie ED. Therapeutic interventions, including lifestyle changes, antiglycemic agents and lipid-regulating therapies, aim to correct hyperglycemia and atherogenic dyslipidemia and to improve ED. However, high residual cardiovascular risk is seen in both research and clinical practice settings. Well-designed studies of endothelial function in appropriately selected volunteers afford a good opportunity to test new therapeutic interventions, paving the way for clinical trials and utilization in the care of the diabetic patient. However, based on the results from a recent clinical trial, niacin should not be added to a statin in individuals with low high-density lipoprotein cholesterol and very well controlled low-density lipoprotein cholesterol.

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Section: Combination Therapiesmentioning

confidence: 95%

Section: Lipid-regulating Therapymentioning

confidence: 99%

Endothelial Dysfunction in Diabetes: Pathogenesis, Significance, and Treatment

2013

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“…The same was the target of co-enzyme Q 10 action. It ameliorated bioenergetics parameters, increased the activity of extracellular superoxide dismutase (EC-SOD) and endothelium-related dilatation after one month of oral dose (300 mg per day) by the patients with coronary artery disease [14]. Clinical trials of food (diet) antioxidants (vitamins E, C, polyphenols, carotenoids/lycopine, beta-carotene/, co-enzyme Q 10 ) are actively held now, aiming at prevention of atherogenic oxidation of low-density lipoproteins and oxidative damage of endothelium.…”

Section: Wide Scope Of Antioxidant Researchmentioning

confidence: 99%

Enzymatic Antioxidants: Next Phase of Pharmacological Effort to Fight Oxidative Stress?

Maksimenko¹,

Vavaev²,

Tischenko³

2010

TOPROCJ

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Abstract:The focus in the research of antioxidants is notably displaced in favour of research of enzyme derivatives. Extracellular superoxide dismutase (EC-SOD) is of the particular interest, as it demonstrates in vivo the protective action against development of atherosclerosis, hypertension, heart failure, diabetes mellitus. The reliable association of coronary artery disease with the decreased level of heparin-released EC-SOD was established in clinical researches. To base and develop antioxidant therapy, various SOD isozymes, catalase (CAT), the methods of experimental gene therapy, combined application of SOD-and CAT-activities are used. Covalent bienzyme SOD -CHS -CAT conjugate (where CHS -chondroitin sulphate) showed in the experimental trials its high efficacy as the antithrombotic agent. Pre-clinical research data approve the reliable option to gain for it the status of drug candidate. The trend to use the components of glycocalyx and extracellular matrix for target delivery of medical substances is evident. Development of new enzyme antioxidants for therapeutical destination is closely connected with becoming and progress of medical biotechnology, pharmaceutical industry, bioeconomy.

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“…An increase in hepatic SOD and anti-ROS capacity in broilers was observed by CoQ10 supplementation (Geng et al, 2004b). The supplementation of CoQ10 increases the SOD activity by antagonizing Nitric Oxide (NO) inactivation; thereby making more NO availability for the biological function which leads to extracellular SOD gene-expression (Tiano et al, 2007). The reduced glutathione and glutathione peroxidase activity were also increased by CoQ10 at 20 mg kgG 1 (Lakomkin et al, 2005;Huang et al, 2011;Gopi, 2013).…”

Section: Coenzyme Q10 Antioxidant Propertiesmentioning

confidence: 99%

Dietary Essentiality I: Coenzyme Q10 Conditionally Essential-Review

Gopi¹,

Kumar²,

Elaiyaraja³

et al. 2015

Asian J. of Animal and Veterinary Advances

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The essentiality of nutrients keeps on changing with the advancement in nutritional research and genetic gain. The genetic gain especially in poultry sector is very high which results in increase in nutrient requirement of both the essential and non-essential nutrients. For the rapid growth the requirement of essential nutrients reaches many folds which are in direct relation with the performance, but the requirement for non-essential nutrients is an indirect one. Most of the dispensable amino acids, vitamin C, carnitine, etc. which are being synthesized endogenously are now a days unable to meet the birds requirements that warrants the dietary supply. Another important nutrient is coenzyme Q10 (CoQ10) which endogenously synthesized is now gaining much attention as a supplement for fast growing broilers. The CoQ10 can be termed as multi-functionary as each and every cell in the body needs this but quantity is being high for very active organs like heart, lungs, liver, kidney, etc. They are essential for cellular oxidative phosphorylation and regenerative antioxidant. The supplementation of CoQ10 improved the feed efficiency with reducing the electron leaks from mitochondria and increases total antioxidant capacity. For this property, CoQ10 is widely used in human medicine especially persons suffering from cardiac, neurological disorder, hypercholesterolemic condition and also even in cancer. The CoQ10 in poultry draws first attention when it is found to reducing the ascites mortality in marketable broilers. Thereafter, the advantages of CoQ10 is started to exploit with much attention to ascites, feed efficiency, cholesterol lowering effect nutraceutical and nutrigenomic property both in poultry and swine industry.

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Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study

Cited by 131 publications

References 29 publications

Endothelial Dysfunction in Diabetes: Pathogenesis, Significance, and Treatment

Endothelial Dysfunction in Diabetes: Pathogenesis, Significance, and Treatment

Enzymatic Antioxidants: Next Phase of Pharmacological Effort to Fight Oxidative Stress?

Dietary Essentiality I: Coenzyme Q10 Conditionally Essential-Review

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