Effect of Coenzyme Q<sub>10</sub> on Th1/Th2 Paradigm in Females with Idiopathic Recurrent Pregnancy Loss

Talukdar, Ayantika; Sharma, Kshitiz; Rai, Reeta; Deka, Dipika; Rao, D.N.

doi:10.1111/aji.12376

Cited by 10 publications

(5 citation statements)

References 33 publications

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“…Tim-3 and its ligand Gal-9 interaction initiates intracellular calcium influx and suppresses Th1 and Th17 cells (137)(138)(139). The Tim-3 blockade induced increased Th1 cytokines at the maternal-fetal junction, and immune tolerance was disrupted (140). Contrarily, Tim-3 can also keep decidual stromal cells from inflammatory damages and TLR-mediated apoptosis by enhancing Th2 immunity at the maternal-fetal junction (141,142).…”

Section: The Regulation Of T Helper Cells Via Co-inhibitory Receptorsmentioning

confidence: 99%

T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1/Th2/Th9/Th17/Th22/Tfh Cells

et al. 2020

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During pregnancy, various immune effectors and molecules participating in the immunemicroenvironment establish specific maternal tolerance toward the semi-allogeneic fetus. Activated maternal immune effectors by the trophoblast antigens, such as T helper (Th), T cytotoxic (Tc), T regulatory (Treg), and B cells, are involved in the regulation of adaptive immunity. Recognition of active signal through the T cell receptors stimulate the differentiation of naive CD3 + CD4 + T cells into specific T cell subsets, such as Th1, Th2, Th9, Th17, Th22, and follicular Th cells (Tfh). Each of these subsets has a significant and distinct role in human pregnancy. Th1 immunity, characterized by immune-inflammatory responses, becomes dominant during the peri-implantation period, and the "controlled" Th1 immunity benefits the invading trophoblasts rather than harm. Quickly after the placental implantation, the early inflammatory Th1 immunity is shifted to the Th2 antiinflammatory immune responses. The predominant Th2 immunity, which overrules the Th1 immunity at the placental implantation site, protects a fetus by balancing Th1 immunity and accommodate fetal and placental development. Moreover, Treg and Th9 cells regulate local inflammatory immune responses, potentially detrimental to the fetus. Th17 cells induce protective immunity against extracellular microbes during pregnancy. However, excessive Th17 immunity may induce uncontrolled neutrophil infiltration at the maternal-fetal interface. Other Th cell subsets such as Tfh cells, also contribute to pregnancy by setting up favorable humoral immunity during pregnancy. However, dysregulation of Th cell immunity during pregnancy may result in obstetrical complications, such as recurrent pregnancy losses (RPL) and preeclampsia (PE). With this review, we intend to deliver a comprehensive overview of CD4 + Th cell subsets, including Th1, Th2, Th9, Th17, Th22, and Tfh cells, in human pregnancy by reviewing their roles in normal and pathological pregnancies.

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Section: The Regulation Of T Helper Cells Via Co-inhibitory Receptorsmentioning

confidence: 99%

T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1/Th2/Th9/Th17/Th22/Tfh Cells

et al. 2020

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“…In support of the role of disturbed immune milieu in pathogenesis and/or recurrence of PL, Talukdar et al (21) detected significantly decreased percentage of Thl cells with significantly decreased levels of IFN-y and TNF-a in the culture supernatant of peripheral blood mononuclear cell (PBMC) from RPL women and treated in vitro with CoQ10 than in untreated cells and attributed this effect to the capability of CoQ10 in reducing oxidative stress by decreasing reactive oxygen species production. Also, Ota et al (22) experimentally detected significantly decreased Toll-like receptor-4 (TLR4) expression on natural killer (NK) cells and significantly reduced production of TNF-a and IFN-y on incubation of NK cells of RPL women with di-hydroxy vitamin D3 through interference with nuclear factor-KB.…”

Section: Discussionmentioning

confidence: 97%

Disturbed inflammatory/anti-inflammatory milieu and activation of Primary Phase Reactants may underlie Development and Recurrence of First trimester Pregnancy Loss.

Al-Sherbeny

Hassaan²

2017

The Egypt. J. of Fert.y of Steri.

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Objective: Estimation of serum levels of tumor necrosis factor-a (TNF-a), interleukin (IL-) 6 and 10 and alpha-1 antitrypsin (AAT) in pregnant women with current pregnancy loss (CPL) and non-pregnant women with history of recurrent PL (RPL) compared versus women with normal pregnancy (NP). Patients & Methods: All studied women underwent clinical and vaginal ultrasonographic examination for assurance of inclusion criteria and then gave blood samples for ELISA estimation of studied parameters. Results: Patients of CPL and RPL groups showed significantly high serum TNF-a and IL-6 levels with significantly lower serum IL-10 levels than women of NP group with significant difference between CPL and RPL groups. Serum AAT levels were significantly lower in CPL group than RPL and NP groups with significantly lower levels in RPL than NP group. High serum TNF-a and low AAT levels showed high positive predictive value (PPV) and sensitivity, respectively, for possibility of presence or recurrence of PL Conclusion: Disturbed serum levels of pro-and anti-inflammatory cytokines could diagnose CPL with high PPV and persistence of their disturbed levels may predispose to RPL. Activation of primary phase reactant system may underlie, accompany or initiate PL, so low serum AAT during 1st trimester and its persistently low serum levels during interpregnancy intervals could be used as screening test for presence or liability for development of PL.

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“…The Th2-type cytokine IL-4 is relevant to Alzheimer's disorders and protective against depression due to its ability to counter-regulate inflammation [54] and contribute to acquired stress resilience through BDNF-dependent neurogenesis [55]. Since the relationship between ubiquinol and IL-4 we uncovered suggests the relevance of the immune system in this feasibility step, further experiments should be performed using flow cytometry to identify the involvement of immune cell types in peripheral blood mononuclear cells (PBMCs) [56].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Ubiquinol Intake and Sociophysical Training on the Activation of Psychological and Infrared Camera-Measured Body Temperature Physiology and Blood Molecular Markers: A Pilot Study among Healthy Female Older Adults

Ota,

Hariyama,

Colman

et al. 2024

Applied Sciences

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A combination of existing treatments with sensing technology may be the most appropriate approach for incurable neuropsychiatric disorders. Dietary antioxidant supplementation, exercise, and cognitive training are individually well-established treatments for neurodegeneration, Alzheimer’s disease, and other dementias. Therefore, in a double-blind randomized controlled trial, we evaluated the response of normal healthy older female subjects to coenzyme Q10 supplementation and simultaneous sociophysical training that was undertaken in a non-contact environment using infrared cameras. The current pilot study reports the results from a multivariate analysis of blood biomarkers, body surface temperature measured with infrared thermal cameras, and psychological questionnaire scores from this trial, in which 100 mg/day of supplemental ubiquinol (the reduced form of coenzyme Q10) was administered daily for one month. We found a significant positive correlation between ubiquinol supplementation and positive mood scores in the State–Trait Anxiety Inventory test (STAI-positive) and a weak inverse correlation between ubiquinol supplementation and serum interleukin 4 (IL-4), a systemic inflammatory marker. We also found a significant positive correlation between the standard deviation of body surface temperatures, detected with non-contact infrared image sensors, and both STAI-positive and serum antidiuretic hormone (ADH). The results from this small pilot study indicate the potential synergistic effects of oral ubiquinol intake and sociophysical training on neuropsychiatric health in healthy female older adults.

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Effect of Coenzyme Q₁₀ on Th1/Th2 Paradigm in Females with Idiopathic Recurrent Pregnancy Loss

Cited by 10 publications

References 33 publications

T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1/Th2/Th9/Th17/Th22/Tfh Cells

T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1/Th2/Th9/Th17/Th22/Tfh Cells

Disturbed inflammatory/anti-inflammatory milieu and activation of Primary Phase Reactants may underlie Development and Recurrence of First trimester Pregnancy Loss.

The Effects of Ubiquinol Intake and Sociophysical Training on the Activation of Psychological and Infrared Camera-Measured Body Temperature Physiology and Blood Molecular Markers: A Pilot Study among Healthy Female Older Adults

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Effect of Coenzyme Q10 on Th1/Th2 Paradigm in Females with Idiopathic Recurrent Pregnancy Loss

Cited by 10 publications

References 33 publications

T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1/Th2/Th9/Th17/Th22/Tfh Cells

T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1/Th2/Th9/Th17/Th22/Tfh Cells

Disturbed inflammatory/anti-inflammatory milieu and activation of Primary Phase Reactants may underlie Development and Recurrence of First trimester Pregnancy Loss.

The Effects of Ubiquinol Intake and Sociophysical Training on the Activation of Psychological and Infrared Camera-Measured Body Temperature Physiology and Blood Molecular Markers: A Pilot Study among Healthy Female Older Adults

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Effect of Coenzyme Q₁₀ on Th1/Th2 Paradigm in Females with Idiopathic Recurrent Pregnancy Loss