Effect of Coelogyne cristata Lindley in alleviation of chronic fatigue syndrome in aged Wistar rats

Mitra, Ashok; Sur, Tapas Kumar; Upadhyay, S. N.; Bhattacharyya, Dipankar; Hazra, Jayram

doi:10.1016/j.jaim.2017.06.011

Cited by 6 publications

(6 citation statements)

References 33 publications

(50 reference statements)

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“…In this investigation, the animals were rendered to a single dose of LPS and forced swim trials to induce a state of chronic fatigue.Swiss albino mice were enforced to swim for each 10 minutestime for daily 21 days in a restricted space (jar) from which they cannot escape, and hence, induced to express a characteristic behavior of immobility (fatigue response) thatwas measured on every alternate day.When compared to the LPS group, the Olmesartan administration prompted a noteworthy reduction in the immobility stint on the 7 th , 13 th , and 21 st days.In line with earlier outcomes (Dhir et al2012;Mitra et al 2017), the current ndings depicted that the level of fatigue was elevated in various behavioral tests viz.locomotor activity (in open eld test), anxiety-like symptoms (in elevated zero maze), and memory loss (in plus-maze tests). In this study,the LPS group (fatigue control animal) indicateda reduction in their locomotor activity.…”

Section: Discussionsupporting

confidence: 92%

“…In previous reports, the extent of oxidative strain indicators such as brain TBARS and GSH were shown to be signi cantly correlated with the aforementioned behavioral measures and CFS (Dhir et al2012;Mitra et al 2017).Our ndings showed that Olmesartan reduced TBARS content,whereasit increased GSH levels and thus, improved cellular antioxidant strength in rodent brains, which aptlysubstantiates the proposition that Olmesartantreatment might contribute to managingpro-oxidative molecules in CFS.The HPA axis was triggered by oxidative stress culminated by LPS injection, and this resulted in increased plasma cortisol levels.Cortisol is released when the body is under stress physical or emotional (Dhama et al 2019).When the hypothalamus secretes corticotrophin-releasing hormone (CRH), it kindlesthe pituitary gland for ACTH release. The adrenal glands react to stress by releasing cortisol from the adrenal cortex under the in uence of ACTH.The quantity of cortisol secreted in humans is regulated by a feedback loop that arises from the interplay between the total concentration of plasma cortisol and the pituitary gland.…”

Section: Discussionmentioning

confidence: 89%

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Olmesartan alleviates symptoms of chronic fatigue syndrome in mice

Saqulain¹,

Sharma²,

Kushwah³

et al. 2022

Preprint

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Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME) is a lifestyle-related ailment that affects physical and mental abilities. The etiology is largelyunidentified but there are certain multifactorial mechanisms responsible such as mitochondrial aerobic pathways aberrations, hypothalamic-pituitary-adrenal (HPA) axis deregulation, immune hyperactivation, free radicals, pathogen infections, and central neurohumoral alterations. Olmesartan is an antihypertensive drugthat acts on the angiotensin 1 (AT1) receptor. The present research evaluatedthe efficiency of OlmesartanagainstCFS. CFSwas induced by lipopolysaccharide (LPS, 1mg/kg,i.p.) once on day 1 trailed by a forced swim (10minutes)continued for 21 consecutive times once each day. Olmesartan (1and 3mg/kg,p.o.) and dexamethasone (standard drug, 0.5mg/kg, i.p.) were given from the 1st to 21stday. Immobility time was noted in the forced swim test (FST). Elevated plus maze, raised zero maze, and open field tests were employed to assess animal behavior.Plasma glucose and cortisol, lipid peroxidation, and GSH levels were determined in the whole brain. LPS and repeated forced swim sessions instigated symptoms of CFS such as memory deficit and depression and anxiety-like symptoms. Findings suggested that Olmesartan shortened the immobility period of mice against CFS in FST. Olmesartan reduced memory deficits, increased ambulation, and exerted an anxiolytic effect. Olmesartan treatment reduced blood cortisol levels, brain TBARS, and enhanced brain GSHin the CFS mouse model. Hence, Olmesartan may prove to be an effective treatment for CFS and related behavioral discrepancies.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 89%

Olmesartan alleviates symptoms of chronic fatigue syndrome in mice

Saqulain¹,

Sharma²,

Kushwah³

et al. 2022

Preprint

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“…The effectiveness of the phenanthrene-rich hydroalcoholic extract of pseudobulbs of C. cristata (CCE) in chronic fatigue syndrome (CFS)-induced behavioral changes in aged animals was done by Mitra et al (2018) (Zhao et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Oxidative Stress Biomarkers in Equine Erythrocytes and Plasma after in vitro Treatment with an Aqueous Leaf Extract of Coelogyne brachyptera Rchb. f. (Orchidaceae)

Buyun¹

2022

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Many orchids have been used as medicinal plants for many years in China, Japan, India, and some other countries. They showed many health-beneficial functions, such as the protection of cells against free radicals and oxidative stress possessing hepatoprotection, cardioprotection, gastroprotection, neuroprotection, and other properties. This study aimed to investigate the oxidative stress biomarkers [2-thiobarbituric acid reactive substances (TBARS), aldehydic and ketonic derivatives of oxidatively modified proteins (OMP), and total antioxidant capacity (TAC)] in the equine erythrocytes and plasma after in vitro incubation with an extract derived from leaves of Coelogyne brachyptera Rchb. f. The leaves of C. brachyptera plants, cultivated under glasshouse conditions, were sampled at M.M. Gryshko National Botanic Garden (NBG), National Academy of Science of Ukraine. Freshly collected leaves were washed, weighed, crushed, and homogenized in 0.1M phosphate buffer (pH 7.4) (in the proportion of 1:19, w/w). The equine plasma and erythrocyte aliquots were used in the study. The pellet of blood was re-suspended in phosphate buffer (pH 7.4). A volume of 0.1 ml of the C. brachyptera extract was added to 1.9 ml of clean equine erythrocytes or 1.9 mL of plasma. For positive control (blank), 0.1M phosphate buffer (pH 7.4) added to erythrocytes or plasma was used. Results of our study revealed that erythrocytes were more sensitive to the action of an extract derived from leaves of C. brachyptera. The levels of aldehydic and ketonic derivatives of oxidatively modified proteins in the treated erythrocytes were significantly decreased, while these parameters were no-changed in the equine plasma. The treatment of equine erythrocytes by extract derived from leaves of C. brachyptera increased lipid peroxidation. On the other hand, plasma TBARS level after treatment by extract derived from leaves of C. brachyptera was at the same level as in untreated controls. The level of total antioxidant capacity was not-significantly changed after treatment both in equine plasma and erythrocytes. Studies concerning the antioxidant properties of orchids are continued in our laboratory.

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“…Dopamine alteration is the primary cause of ADHD pathology, which has been extensively considered as a significant factor for the progression of the disease (Albrecht et al., 2015; Bijlenga et al., 2019). The substantial clues involved are decreased release of dopamine in the specific areas of brain‐like, striatum, nucleus accumbens, and prefrontal cortex, further decreased dopamine turnover in the frontal cortex, substantia nigra, and ventral tegmental area, as well as reduced dopamine vesicular storage (Bijlenga et al., 2019; Instanes et al., 2018), and increased density of binding sites for the dopamine D1/D5 receptor family in the anterior forebrain (Mitra et al., 2017; Wu et al., 2012).…”

Section: Pathophysiologymentioning

confidence: 99%

Animal models of attention‐deficit hyperactivity disorder (ADHD)

Rahi

Kumar

2021

Intl J of Devlp Neuroscience

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Attention‐deficit hyperactivity disorder (ADHD) is a heterogeneous neuropsychiatric disorder characterized by three primary symptoms hyperactivity, attention deficit, and impulsiveness, observed in both children and adults. In childhood, this disorder is more common in boys than in girls, and at least 75% will continue to suffer from the disorder until adulthood. Individuals with ADHD generally have poor academic, occupational, and social functioning resulting from developmentally inappropriate levels of hyperactivity and impulsivity, as well as impaired ability to maintain attention on motivationally relevant tasks. Very few drugs available in clinical practice altogether abolish the symptoms of ADHD, therefore, to find new drugs and target it is essential to understand the neuropathological, neurochemical, and genetic alterations that lead to the progression of ADHD. With this contrast, an animal study is the best approach because animal models provide relatively fast invasive manipulation, rigorous hypothesis testing, as well as it provides a better angle to understand the pathological mechanisms involved in disease progression. Moreover, animal models, especially for ADHD, serve with good predictive validity would allow the assessment and development of new therapeutic interventions, with this aim, the present review collect the various animal models on a single platform so that the research can select an appropriate model to pursue his study.

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Effect of Coelogyne cristata Lindley in alleviation of chronic fatigue syndrome in aged Wistar rats

Abstract: The results confirmed the potential therapeutic actions of CCE against experimentally induced CFS in aged rats that might be due to its CNS mediatory antioxidant properties.

Cited by 6 publications

References 33 publications

Olmesartan alleviates symptoms of chronic fatigue syndrome in mice

Olmesartan alleviates symptoms of chronic fatigue syndrome in mice

Oxidative Stress Biomarkers in Equine Erythrocytes and Plasma after in vitro Treatment with an Aqueous Leaf Extract of Coelogyne brachyptera Rchb. f. (Orchidaceae)

Animal models of attention‐deficit hyperactivity disorder (ADHD)

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