Effect of Cocciban herbal coccidiostats on hematobiochemical, fecal parameters and cecal histopathology of broiler chicken

Srinivasu, B; Preetam, V. Chinni; Gurram, Srinivas; Rao, D. S. T.

doi:10.1007/s11250-019-01831-3

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…RBCs, Hb counts, HCT levels, the LY%, WBCs and the NE% changed more significantly in infected than uninfected status in the present study. In line with our observations, Srinivasu et al (2019) reported lower levels of total erythrocyte and haemoglobin content in the infected groups than in the control group. The decrease might be the result of rupture of the villous epithelium, as we observed in several bleeding spots in the infected animals.…”

Section: Discussionsupporting

confidence: 92%

“…The decrease might be the result of rupture of the villous epithelium, as we observed in several bleeding spots in the infected animals. The loss of blood might lead to osmotic imbalance in blood vessels and dilution of the blood, leading the haematocrit level to decrease (Srinivasu et al, 2019). Coccidial schizonts developed in the intestinal villi and damaged a large number of intestinal epithelial cells (Pakandl et al, 2009), and this is likely what caused the haemorrhagic enteritis and led to an increase of WBCs in group A in the present study.…”

Section: Discussionmentioning

confidence: 61%

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Pathological changes and antigen localization in the small intestine of rabbits infected with Eimeria magna

et al. 2021

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Coccidiosis is a major disease caused by various Eimeria species in rabbits. The aim of the present study was to investigate the haematological and pathological changes in rabbits infected with E. magna. Moreover, the localisation of coccidial antigens was examined in the intestines of rabbits with two kinds of serum as primary antibodies. In the present study, forty-five 28-day-old weaned rabbits were randomly divided into three groups and reared in three separate places. Group A was infected with 20×103 sporulated oocysts of E. magna, group B was only used to produce anti-E. intestinalis serum by infecting them with 3×103 sporulated oocysts of E. intestinalis, and group C was designated as the control group. According to histopathological evaluation of group A, the epithelial cells of the jejunum and ileum were parasitised with a large number of oocysts and other stages of E. magna. The haematological results showed that red blood cell counts, haemoglobin counts, haematocrit levels and the percentage of lymphocytes were significantly decreased in group A compared with group C (P<0.01), but white blood cell counts and the percentage of neutrophils were significantly increased (P<0.01). The weight of group A began to decrease on the 5th day after infection, and this decrease continued until the 9th day. Immunohistochemistry staining revealed that two kinds of coccidial antigens were basically located at the same sites of the intestine when anti-E. intestinalis serum and anti-E. magna serum were used as primary antibodies. Most likely, E. magna and E. intestinalis antigens have some similar antigenic determinants; this finding provides a theoretical basis for screening for common antigens of these two coccidian species.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 61%

Pathological changes and antigen localization in the small intestine of rabbits infected with Eimeria magna

et al. 2021

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“…The cecum of chicken is the target organ where could be invaded by eimerian coccidioides. Coccidioides produce a large number of splinters to invade and damage the intestinal epithelial cells at the reproductive stage of fission (Macdonald et al., 2018; Srinivasn et al., 2019) and affect the digestion and absorption function of the intestine, which finally inhibit the growth of the chicken. Oocysts per gram (OPG) can indirectly reflect the ability of coccidioides oocysts to reproduce in animal bodies, and the degree of cecal lesions, relative weight gain rate and the amount of OPG can be used as important indicators for the evaluation of drug efficacy (Zou et al., 2019; Cha et al., 2018).…”

Section: Discussionmentioning

confidence: 99%

Effect of Qing Chang oral liquid on the treatment of artificially infected chicken coccidiosis and the cellular immunity

Zhiqiang

Qian‐lin

Li‐zhi

et al. 2022

Veterinary Medicine & Sci

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Background: Qing Chang oral liquid (QOL) is a veterinary drug, which mainly composed of Artemisiae annuae herba, Dichroae radix, Agrimonia pilosa and Sanguisorbae radix.Objectives: This study aims to explore the effect of Qing Chang Oral Liquid (QOL) on the treatment effect of artificially infected chicken coccidiosis and to the cellular immunity.Methods: Healthy Roman chickens were randomly divided into five groups: blank group, model group, QOL high-, medium-and low-dose groups. All the groups were orally administered with 1 × 10 4 sporulated oocysts (except the blank group). After 5 days of oral administration, the high-, medium-and low-dose groups of QOL were added to the drinking water at 2.4, 1.8 and 1.2 ml/kg, respectively. The blank and model groups were fed normally, and this experiment lasted for 7 days. The clinical signs were observed, and the relative weight gain, survival rate, cecum lesion score and oocyst value were measured to evaluate the effect of QOL. Meanwhile, the peripheral blood T-lymphocyte subsets and cecal IL-2, IL-17, IFN-γ mRNA expression were detected by flow cytometry and fluorescent quantitative PCR. Results:The chickens in the model group were in poor mental state, gathered together, had loose stools or bloody stools and had less food intake and less exercise. The chicken mental state improved, the food intake and drinking water increased, and the faeces are normal in the high-, medium-and low-dose groups, especially in the high-dose group, the anti-coccidial indexes were up to 173.08. No significant differences were observed (p > 0.05) in the peripheral blood CD3 + , CD3 + CD4 + between the experimental groups. Compared with the blank group, there were different degrees of increase in each dose drug group of the cecal IFN-γ, IL-2 and IL-17 mRNA expression, but the highdose group was significantly reduced compared with the model group (p < 0.01), but there was no significant difference (p > 0.05). Conclusions:This study suggests that QOL has positive anti-coccidial effect but has no obvious effect on the cellular immunity.

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Natural Alternatives to Anticoccidial Drugs to Sustain Poultry Production

Aguiar-Martins,

Burrell,

Blake

et al. 2023

Sustainable Use of Feed Additives in Livestock

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Effect of Cocciban herbal coccidiostats on hematobiochemical, fecal parameters and cecal histopathology of broiler chicken

Cited by 5 publications

References 6 publications

Pathological changes and antigen localization in the small intestine of rabbits infected with Eimeria magna

Pathological changes and antigen localization in the small intestine of rabbits infected with Eimeria magna

Effect of Qing Chang oral liquid on the treatment of artificially infected chicken coccidiosis and the cellular immunity

Natural Alternatives to Anticoccidial Drugs to Sustain Poultry Production

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