Effect of coadministration of glibenclamide and methanolic stem extract of Anisopus mannii N.E.Br. (Apocynaceae) on glucose homeostasis and lipid profile in streptozotocin/nicotinamide-induced diabetic rats

Chika, Aminu; Yahaya, Amina

doi:10.5455/njppp.2019.9.0829205092019

Cited by 1 publication

(2 citation statements)

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“…43 After entering, streptozotocin will trigger DNA alkylation. 42,44 Methylnitrosurea from streptozotocin structure is responsible for toxicity activity owned by streptozotocin over the formation of methyl carbonium ions (CH 3+ ), which is extremely reactive producing methylation and DNA fragmentation. 37 The incoming streptozotocin is then metabolised by cells and becomes a donor for the formation of nitric oxide (NO) which contributes to cell damages within the increased activity and the release of free radicals.…”

Section: Resultsmentioning

confidence: 99%

“…51 The mechanism action of glibenclamide is to increase the release of insulin hormone in Langerhans pancreatic β-cells. 44 Sulfonylureas work by hindering K + channels from pancreatic β-cells through sulfonylurea receptors that block the channels of ATP-sensitive K + . 52 This inhibition causes membrane depolarisation, and this condition will open Ca channels.…”

Section: Resultsmentioning

confidence: 99%

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Anti-diabetic Activity of the Red Dragon Fruit Peel (Hylocereus polyrhizus) in Ethanol Extract against Diabetic Rats

Panjaitan¹,

Novitasari²

2021

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Background:The red dragon fruit peel, which is rarely used in general, contains higher antioxidant properties compared to the flesh parts and has various secondary metabolites utilised in medicines. Objectives: This study was aimed to determine the effects of ethanol extract administration of the red dragon fruit peel (Hylocereus polyrhizus) against the decline of blood glucose levels in diabetes mellitus rats. Methods: In this study, the total of 24 male white Wistar rats (Rattus novergicus) were divided into 4 groups. All experimental animals were induced to diabetic conditions by the administration of streptozotocin and nicotinamide dosages at 45 mg/kg body weight and 110 mg/kg body weight, respectively. For 14 days, each group was treated accordingly. The first group or negative control (NC) was treated with the administration of CMC-Na 0.5% dose 2 ml/200 g body weight; the second group or positive control (PC) was administrated with glibenclamide dose 0.09 mg/200 g body weight; the third (E1) and fourth (E2) groups were administered with the ethanol extracts of the red dragon fruit peels at dosages of 37.44 mg/200 g body weight and 74.88 mg/200 g body weight, respectively. Results: After the 14-day trial, the average levels of blood glucose on the negative control group (382.92 mg/dl) experienced no decline, and the blood glucose levels amongst groups were statistically different (p<0.05). Conclusion:The anti-diabetic activity of the red dragon fruit peel in the ethanol extract dose 74.88 mg/200 g body weight is statistically equal to the glibenclamide dose 0.09 mg/200 g body weight.

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