Effect of co-administration of two different phosphodiesterase inhibitors and a β3-adrenoceptor agonist in an experimental model of detrusor overactivity

Linhares, Bruno Lima; Nascimento, Nilberto Robson Falcão do; Gonzaga-Silva, Lúcio Flávio; Santos, Cláudia Ferreira; Moraes, Manoel Odoríco de; Marinho, Lucas Bernardo; Silva, Ana Patrícia Gonçalves; Fonteles, M. C.; Reges, Ricardo

doi:10.1016/j.ejphar.2018.06.018

Cited by 3 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In L-NAME treated mice, rolipram induced more relaxation than the other drugs, enhancing relaxation response to BRL 37344 at almost all concentrations, but no synergistic effect with tadalafil was observed. The relaxant effect of BRL 37344 was enhanced by rolipram but not by tadalafil, suggesting that PDE-4 inhibition, especially when associated with β3-AR, could represent a potential treatment for DO 31 . Thus, other studies using the rolipram and BRL 37344 combination may contribute to the treatment of DO.…”

Section: Discussionmentioning

confidence: 97%

Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice

Carvalho

Pamplona²,

Barreira³

et al. 2019

Acta Cir. Bras.

Self Cite

View full text Add to dashboard Cite

Purpose To evaluate the impact of the combination of BRL 37344 and tadalafil (TDF) on the reduction of overactive bladder (OB) symptoms. Methods Thirty mice were randomized into 5 groups (G) of 6 animals each. L-NAME was used to induce DO. G1: Control; G2: L-NAME; G3: L-NAME + TDF; G4: L-NAME + BRL 37344; G5: L-NAME + TDF + BRL 37344. After 30 days of treatment, the animals were submitted to cystometry to evaluate non-voiding contractions (NVC), threshold pressure (TP), baseline pressure (BP), frequency of micturition (FM) and threshold volume (TV). Differences between the groups were analyzed with ANOVA followed by the Tukey test. Results NVC increased in G2 (4.33±2.58) in relation to G1 (1.50±0.55). NVC decreased in G3 (2.00±1.10), G4 (1.50±1.52) and G5 (2.00±1.26) compared to G2 (p<0.05). FM decreased in G3 (0.97±0.71), G4 (0.92±0.38) and G5 (1.05±0.44) compared to G2 (p<0.05). However, the combination of TDF and BRL37344 was not more effective at increasing NVC and improving FM than either drug alone. The five groups did not differ significantly with regard to TV. Conclusion The combination of BRL 37344 and TDF produced no measurable additive effect on reduction of OB symptoms.

show abstract

Section: Discussionmentioning

confidence: 97%

Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice

Carvalho

Pamplona²,

Barreira³

et al. 2019

Acta Cir. Bras.

Self Cite

View full text Add to dashboard Cite

show abstract

“…S-type APPDs are synthetic intermediates for the synthesis of cardiac propranolol, which is a drug for the treatment of cardiovascular diseases. 1,2 They can also be used to synthesize phosphodiesterase inhibitors 3,4 for the treatment of heart disease. Furthermore, R-type APPDs are precursors for a synthetic insect growth regulator.…”

Section: Introductionmentioning

confidence: 99%

Efficient resolution of 3-aryloxy-1,2-propanediols using CLEA-YCJ01 with high enantioselectivity

Wang

2019

RSC Adv.

View full text Add to dashboard Cite

show abstract

Current and Emerging Pharmacological Targets and Treatments of Urinary Incontinence and Related Disorders

et al. 2023

View full text Add to dashboard Cite

Effect of co-administration of two different phosphodiesterase inhibitors and a β3-adrenoceptor agonist in an experimental model of detrusor overactivity

Cited by 3 publications

References 25 publications

Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice

Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice

Efficient resolution of 3-aryloxy-1,2-propanediols using CLEA-YCJ01 with high enantioselectivity

Current and Emerging Pharmacological Targets and Treatments of Urinary Incontinence and Related Disorders

Contact Info

Product

Resources

About