Effect of co-administration of metformin and extracts of Costus pictus D.Don leaves on alloxan-induced diabetes in rats

Naik, Ami; Adeyemi, Sherif Babatunde; Vyas, Bhavin; Krishnamurthy, R.

doi:10.1016/j.jtcme.2021.08.007

Cited by 21 publications

(8 citation statements)

References 37 publications

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“…Diabetes caused by alloxan is related to selective reduction of insulin production via glucokinase inhibition and promotion of ROS generation. As a result, such a poison will cause necrosis of the pancreatic β-cells [28], [29].…”

Section: Discussionmentioning

confidence: 99%

Possible Effects of Dinitrophenol and Caffeine on Diabetic Adult Male Albino Rat

El-feky,

Mersal,

Gabr

2023

International Journal of Theoretical and Applied Research

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Diabetes is a major health problem characterized by inadequate hyperglycemia due to relative or absolute insulin deficiency at the cellular level. Dinitrophenol causes weight loss by uncoupling oxidative phosphorylation. While caffeine use on a regular basis is linked to a decreased risk of diabetes and Parkinson's disease. Dinitrophenol and caffeine decrease oxidative stress. Diabetes leads to increased oxidative stress so they can decrease blood glucose. In this research, 70 male albino rats were selected, with body weight ranging between 100-160 g, and divided into 7 groups, a control group, a dinitrophenol group, a caffeine group, and d diabetic group. Rats were given only one dosage of alloxan by intraperitoneal injection. Rats with diabetes were separated into the diabetic group, diabetic-dinitrophenol, diabetic-caffeine, and diabetic-dinitrophenolcaffeine treated groups. After 8 weeks, we measured glucose, insulin, lipid indicators, antioxidants, and oxidative stress markers. The diabetic group showed a very high elevation in glucose levels compared to the control group. The diabetic-dinitrophenolcaffeine group showed more reduction in blood glucose levels. All treated groups showed an increase in insulin levels. Lipid profiles showed variations in different groups. All treated groups had increased oxidative stress markers associated with increased antioxidant markers.

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Section: Discussionmentioning

confidence: 99%

Possible Effects of Dinitrophenol and Caffeine on Diabetic Adult Male Albino Rat

El-feky,

Mersal,

Gabr

2023

International Journal of Theoretical and Applied Research

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“…and reduce the hyperglycemias after postprandial [13][14][15][16][17]. The enzyme α-amylase is catalyses and breakdown of carbohydrates in to glucoses [18], So that inhibition of alpha amylase enzyme, leads to control the blood glucose levels [19]. Therefore in this study investigating the Apigenin efficacy in regulating blood glucose levels by inhibition of alpha amylase in alloxan induced type 2 diabetes.…”

Section: Introductionmentioning

confidence: 94%

Antioxidant and Alpha Amylase Inhibitory Activity of Apigenin in Alloxan Induced Diabetic Rats

Shailendra,

Shankaraiah

2024

UPJOZ

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Purpose: to study the antioxidant, inhibitory activity of alpha amylase, antidiabetic, effects of flavonoid Apigeninin in diabetic rats. Methods: The effect of Apigeninon on blood glucose and antioxidant activities were estimated in alloxan induced diabetic and treated rats. The α-amylase inhibitory activity in the serum was assessed after oral administration of 7thday, 14th day, and 21st days treatment of Apigenin. Results: The Apigenin was reduced the serum glucose, α-amylase levels and increased antioxidant levels significantly (P<0.05) in Apigenin alone and combination with Metformin treated groups. Conclusion: The present investigation concludes that flavonoid Apigenin, single drug and combination with Metformin was increased antioxidant and inhibited the alpha-amylase activity and hypoglycemic effect in alloxan induced diabetes rats.

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“…Costus pictus, also known as insulin plant, fiery Costus , and spiral flag ( Selvakumarasamy et al., 2021 ) is widely used in the traditional management of diabetes, and its methanolic extract has shown synergistic antidiabetic effect with metformin in the alloxan-induced diabetic model ( Naik et al., 2022 ). The main active compounds in this plant are alpha and beta amyrin.…”

Section: Medicinal Plants Controlling Thyroid Hormones Disordersmentioning

confidence: 99%

Medicinal plants’ proposed nanocomposites for the management of endocrine disorders

Zarzour

Kamarulzaman

Saqallah

et al. 2022

Heliyon

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Effect of co-administration of metformin and extracts of Costus pictus D.Don leaves on alloxan-induced diabetes in rats

Cited by 21 publications

References 37 publications

Possible Effects of Dinitrophenol and Caffeine on Diabetic Adult Male Albino Rat

Possible Effects of Dinitrophenol and Caffeine on Diabetic Adult Male Albino Rat

Antioxidant and Alpha Amylase Inhibitory Activity of Apigenin in Alloxan Induced Diabetic Rats

Medicinal plants’ proposed nanocomposites for the management of endocrine disorders

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